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1.发明授权
公开(公告)号：US4163864A
公开(公告)日：1979-08-07
申请号：US878470
申请日：1978-02-16
申请人： Eiichi Morita , Hirosaburo Ejiri , Keizo Takayanagi , Yukio Morita , Yasuhide Tanaka , Shizumasa Kijima , Kimio Hamamura , Isao Yamatsu
发明人： Eiichi Morita , Hirosaburo Ejiri , Keizo Takayanagi , Yukio Morita , Yasuhide Tanaka , Shizumasa Kijima , Kimio Hamamura , Isao Yamatsu
IPC分类号： A61K31/09 , A61P1/16 , A61P9/00 , A61P9/08 , A61P9/10 , B01J27/00 , C07B61/00 , C07C41/00 , C07C41/30 , C07C43/23 , C07C46/06 , C07C50/28 , C07C67/00
摘要： 2-METHYL-3-PRENYL-4,5,6-TRIMETHOXYPHENOL OF THE FORMULA: ##STR1## wherein R represents a group of the formula: ##STR2## WHEREIN N IS AN INTEGER OF 0 TO 9 AND A and B represent hydrogen atom or A--B may form a bond,Is prepared by reacting 6-methyl-2,3,4-trimethoxyphenol with a prenol or isoprenol substituted by the group R as defined above in the presence of a complex catalyst comprising Lewis acid and a silica-alumina compound.
摘要翻译： 2-甲基-3-丙烯基-4,5,6-三甲氧基苯酚：其中R表示下式的基团：其中N为0至9的整数，A和B表示氢原子 或AB可以形成键，其是通过在包含路易斯酸和二氧化硅 - 氧化铝的复合催化剂存在下，如上定义的由如上定义的基团R取代的PRENOL或异丙苯反应6-甲基-2,3,4-三羟甲基酚制备的 复合。
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公开(公告)号：US4107193A
公开(公告)日：1978-08-15
申请号：US796693
申请日：1977-05-13
申请人： Shizumasa Kijima , Toshiji Igarashi , Isao Yamatsu , Kimio Hamamura , Yoshikage Nakajima , Norio Minami , Youji Yamagishi , Yuithi Inai
发明人： Shizumasa Kijima , Toshiji Igarashi , Isao Yamatsu , Kimio Hamamura , Yoshikage Nakajima , Norio Minami , Youji Yamagishi , Yuithi Inai
IPC分类号： C07C69/587 , A61K31/19 , A61K31/20 , A61K31/22 , A61K31/23 , A61P9/12 , C07C51/00 , C07C51/353 , C07C57/03 , C07C67/00 , C09F5/08 , C11C3/02
CPC分类号： C07C57/03
摘要： A polyprenyl carboxylic acid compound represented by the following general formula: ##STR1## wherein R stands for a hydrogen atom or an alkyl, alkenyl, cycloalkyl or aryl group, and n is an integer of 6 to 11. This compound is effective to treat hypertension of warm blooded animals.
摘要翻译： 由以下通式表示的聚异戊二烯羧酸化合物：其中R代表氢原子或烷基，烯基，环烷基或芳基，n为6至11的整数。该化合物可有效治疗高血压 的温血动物。
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公开(公告)号：US4039573A
公开(公告)日：1977-08-02
申请号：US621084
申请日：1975-10-09
申请人： Shizumasa Kijima , Isao Yamatsu , Kimio Hamamura , Norio Minami , Youji Yamagishi , Yuichi Inai
发明人： Shizumasa Kijima , Isao Yamatsu , Kimio Hamamura , Norio Minami , Youji Yamagishi , Yuichi Inai
IPC分类号： C07C69/035 , B01J27/00 , B01J31/00 , C07C41/00 , C07C43/23 , C07C46/06 , C07C50/28 , C07C67/00 , C07C43/22 , C07C69/16
摘要： 2,3-DIMETHOXY-5-SUBSTITUTED-6-METHYL-1,4-BENZOHYDROQUINONE OR 1-MONOESTER THEREOF IS PREPARED BY REACTING 2,3-DIMETHOXY-6-METHYL-1,4-BENZOHYDROQUINONE OR 1-MONOACYLESTER THEREOF WITH PRENOL, ISOPRENOL OR DERIVATIVES THEREOF IN THE PRESENCE OF AN ACIDIC CATALYST FOR CONDENSATION WHICH IS ADSORBED ON AN ADSORBENT. This obtained compound is easily converted to quinone compounds which produces many clinical effects in medical and pharmaceutical uses.
摘要翻译： 2,3-二甲基-5-取代的6-甲基-1,4-苯并噻唑酮或其单 - 单体是通过用PRENOL反应2,3-二甲基-6-甲基-1,4-苯并噻唑酮或其单 - 单体等制备的。 ，其中存在酸性催化剂的异丙酚或其衍生物，用于在吸附剂上吸收的凝血剂。 所得化合物容易转化为在医疗和药物用途中产生许多临床效果的醌化合物。
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4.发明授权Polyprenyl carboxylic acid compound and hypotensive agent containing it as active ingredient 失效聚丙烯酰羧酸化合物和含有它作为活性成分的降压药
公开(公告)号：US4130659A
公开(公告)日：1978-12-19
申请号：US903395
申请日：1978-05-08
申请人： Shizumasa Kijima , Toshiji Igarashi , Isao Yamatsu , Kimio Hamamura , Yoshikage Nakajima , Norio Minami , Youji Yamagishi , Yuithi Inai
发明人： Shizumasa Kijima , Toshiji Igarashi , Isao Yamatsu , Kimio Hamamura , Yoshikage Nakajima , Norio Minami , Youji Yamagishi , Yuithi Inai
CPC分类号： C07C57/03
摘要： A polyprenyl carboxylic acid compound represented by the following general formula: ##STR1## wherein R stands for a hydrogen atom or an alkyl, alkenyl, cycloalkyl or aryl group, and n is an integer of 6 to 11. This compound is effective to treat hypertension of warm blooded animals.
摘要翻译： 由以下通式表示的聚异戊二烯羧酸化合物：其中R代表氢原子或烷基，烯基，环烷基或芳基，n为6至11的整数。该化合物可有效治疗高血压 的温血动物。
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公开(公告)号：US5102895A
公开(公告)日：1992-04-07
申请号：US636129
申请日：1990-12-31
申请人： Noriyasu Hirose , Kimio Hamamura , Takaharu Nakamura , Kiiti Ema , Takashi Banba , Tetsuya Nakamura , Hidetoshi Kawashima , Yuuichi Inai , Noritoshi Sano , Yuko Miyauchi , Shizumasa Kijima
发明人： Noriyasu Hirose , Kimio Hamamura , Takaharu Nakamura , Kiiti Ema , Takashi Banba , Tetsuya Nakamura , Hidetoshi Kawashima , Yuuichi Inai , Noritoshi Sano , Yuko Miyauchi , Shizumasa Kijima
IPC分类号： C07D405/12 , A61K31/443 , A61K31/455 , A61P3/02 , A61P9/10 , C07D405/14 , C07D407/12 , C07D493/04
CPC分类号： C07D405/14
摘要： The novel vitamin E derivative provides an excellent antihyperlipemic effect and is defined by the formula (I): ##STR1## wherein R represents a nicotinoyl group; and m is an integer of from 2 to 5 while n is an integer of from 3 to 6, provided that n is larger than m.
摘要翻译： 新型维生素E衍生物提供优异的抗高脂血症作用，并由式（I）定义：其中R表示烟酰基; m为2〜5的整数，n为3〜6的整数，n大于m。
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公开(公告)号：US5104996A
公开(公告)日：1992-04-14
申请号：US192661
申请日：1988-05-11
申请人： Noriyasu Hirose , Kimio Hamamura , Yuichi Inai , Kiiti Ema , Takashi Banba , Shizumasa Kijima
发明人： Noriyasu Hirose , Kimio Hamamura , Yuichi Inai , Kiiti Ema , Takashi Banba , Shizumasa Kijima
摘要： 2,3,5-trimethyl-benzoquinone is produced by oxidizing 2,3,6-trimethyl-phenol in the presence of a catalyst of cupric chloride and lithium chloride in a solvent mixture of an aromatic hydrocarbon and a lower aliphatic alcohol having 1 to 4 carbon atoms.
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7.发明授权
公开(公告)号：US4130648A
公开(公告)日：1978-12-19
申请号：US860319
申请日：1977-12-14
IPC分类号： C07D239/545 , A61K31/505 , A61K31/506 , A61K31/513 , A61P35/00 , C07D311/04 , C07D405/12 , C07D239/54
CPC分类号： C07D405/12 , A61K31/505
摘要： Novel 5-fluorouracil derivatives of the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrogen atom or methyl group, and R.sub.4 represents a straight or branched alkyl or alkenyl group, which has low toxicity and improved antitumor activity, and novel antitumor preparations containing the said 5-fluorouracil derivative.
摘要翻译： 新颖的5-氟尿嘧啶衍生物，其通式如下：其中R1，R2和R3各自表示氢原子或甲基，R4表示直链或支链烷基或烯基，具有低毒性和改善的抗肿瘤活性， 含有所述5-氟尿嘧啶衍生物的抗肿瘤制剂。
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公开(公告)号：US5245060A
公开(公告)日：1993-09-14
申请号：US849967
申请日：1992-03-12
IPC分类号： B01J31/12 , C07B61/00 , C07C249/02 , C07C251/12
CPC分类号： C07C251/12 , C07C2101/14
摘要： A terpene derivative represented by the general formula (I): ##STR1## wherein R.sup.1 represents a lower alkyl group; R.sup.2 represents an alkyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group, an arylalkyl group or a heteroaryl group; n is 0 or 1 or 2; and the symbol " " represents a single or double bond with the proviso that both of the linkages adjacent to each other are not simultaneously single bonds or double bonds which are useful for the preparation of drug, food, perfume and so on, and a process for preparing thereof.
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公开(公告)号：US4057568A
公开(公告)日：1977-11-08
申请号：US725427
申请日：1976-09-22
申请人： Shizumasa Kijima , Isao Yamatu , Kimio Hamamura , Norio Minami , Youji Yamagishi , Yuichi Inai
发明人： Shizumasa Kijima , Isao Yamatu , Kimio Hamamura , Norio Minami , Youji Yamagishi , Yuichi Inai
IPC分类号： C07F5/04
CPC分类号： C07F5/04
摘要： 2,3-DIMETHOXY-5-METHYL-6-SUBSTITUTED-1,4-BENZOQUINONE HAVING THE FORMULA: ##STR1## in which S is an integer of 0 to 11 and A and B stand for hydrogen or may form a direct bond,Is prepared by reacting boric acid ester of 2,3-dimethoxy-5-methyl-1,4-benzohydroquinone with prenol or isoprenol having the above group R and subsequently reacting the resulting borate with a mild oxidant. The compound is useful as coenzyme Q and has various clinical effects.
摘要翻译： 具有该公式的2,3-二甲基-5-甲基-6-取代的1,4-苯并噻吩酮：其中S为0至11的整数，A和B代表氢或可形成 直接键合，是通过使具有上述组R的具有丙烯酸或异丙酚的2,3-二甲基-5-甲基-1,4-苯并二唑的硼酸反应制备的，随后使得到的硼酸盐与温和的氧化剂反应。 该化合物可用作辅酶Q并具有多种临床效果。
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公开(公告)号：US3998858A
公开(公告)日：1976-12-21
申请号：US640305
申请日：1975-12-12
申请人： Shizumasa Kijima , Isao Yamatu , Kimio Hamamura , Norio Minami , Youji Yamagishi , Yuichi Inai
发明人： Shizumasa Kijima , Isao Yamatu , Kimio Hamamura , Norio Minami , Youji Yamagishi , Yuichi Inai
CPC分类号： C07F5/04
摘要： 2,3-DIMETHOXY-5-METHYL-6-SUBSTITUTED-1,4-BENZOQUINONE HAVING THE FORMULA: ##STR1## in which R is ##STR2## in which S is an integer of 0 to 11 and A and B stand for hydrogen or may form a direct bond, is prepared by reacting a boric acid ester of 2,3-dimethoxy-5-methyl-1,4-benzohydroquinone with prenol or isoprenol having the above group R and subsequently reacting the resulting borate with a mild oxidant. The compound is useful as coenzyme Q and has various clinical effects.
摘要翻译： 具有该公式的2,3-二甲基-5-甲基-6-取代的1,4-苯并噻吩酮：其中S为0至11的整数，A和B代表氢或可形成 直接键合，是通过使具有上述组R的具有丙烯酸或异丙酚的2,3-二甲基-5-甲基-1,4-苯并二唑的硼酸反应制备的，随后使得到的硼酸盐与温和的氧化剂反应。 该化合物可用作辅酶Q并具有多种临床效果。
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