公开(公告)号：US08034003B2

公开(公告)日：2011-10-11

申请号：US12056637

申请日：2008-03-27

申请人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

发明人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

IPC分类号： A61B10/00

CPC分类号： A61B10/025 ,  A61B10/0096 ,  A61B10/0266 ,  A61B10/0283 ,  A61B17/1635 ,  A61B17/32002 ,  A61B2017/320064 ,  A61B2090/0807

摘要： Methods and device for extracting and collecting tissue, which can be used for example in tissue engineering and grafting applications, are disclosed. In one embodiment, a device can include an outer tube. A rotatable shaft can be disposed within the outer tube can have a tissue harvesting tip formed on its distal end, the tissue harvesting tip being effective to excise tissue upon rotation thereof. A tissue collection device can be included to receive and collected excised tissue, and the tissue collection device can indicate the amount of tissue collected therein. For example, the tissue collection device can include a straining element which collects excised tissue and an indicator by which to assess the amount of collected tissue. In some embodiments, the tissue collection device can translate to indicate the amount of collected tissue. In many cases, devices disclosed herein can include driving mechanisms that are adapted to drive a tissue harvesting tip such that the tip excises soft tissue, but stops when contacting bone (or soon after contacting bone). In some embodiments, the tissue harvesting tip can be effective to excise viable tissue samples, such that the samples can exhibit desirable proportions of viable cells. Further, in some embodiments, the tissue harvesting tips can excise a tissue sample with tissue particles falling in certain size ranges.

摘要翻译： 公开了用于提取和收集组织的方法和装置，其可以用于组织工程和移植应用中。 在一个实施例中，装置可以包括外管。 旋转轴可以设置在外管内，可以具有形成在其远端上的组织收集尖端，组织收集尖端有效地在旋转时切除组织。 可以包括组织收集装置以接收和收集切除的组织，并且组织收集装置可以指示其中收集的组织的量。 例如，组织收集装置可以包括收集切除的组织的应变元件和用于评估收集的组织的量的指示器。 在一些实施例中，组织收集装置可以平移以指示收集的组织的量。 在许多情况下，本文公开的装置可以包括适于驱动组织收集尖端的驱动机构，使得尖端切除软组织，但是当接触骨骼时（或者在接触骨骼之后不久）停止。 在一些实施方案中，组织采集尖端可有效地切除活组织样品，使得样品可以显示出所需比例的活细胞。 此外，在一些实施例中，组织采集尖端可以用落在一定尺寸范围内的组织颗粒来切除组织样本。

公开(公告)号：US07175612B2

公开(公告)日：2007-02-13

申请号：US10374706

申请日：2003-02-26

申请人： Augustus Felix ,  Kevin Ranucci ,  Karen E. Kullas ,  Adam P. Angell ,  Lisa Futato ,  Dan Hass

发明人： Augustus Felix ,  Kevin Ranucci ,  Karen E. Kullas ,  Adam P. Angell ,  Lisa Futato ,  Dan Hass

IPC分类号： A61M1/00 ,  F16K24/00 ,  F16K5/10

CPC分类号： A61M1/0047 ,  A61M1/0033 ,  A61M1/0045 ,  Y10T137/3149

摘要： A suction limiting device with variable control for use in a surgical system includes a main vent body having a fluid carrying bore extending therethrough and a variable vent mechanism having a main vent opening in selective fluid communication with the fluid carrying bore so as to permit introduction of atmospheric air into the fluid carrying bore. The vent mechanism being adjustable so that the degree of airflow into the fluid carrying bore is variable between a fully open position to a fully closed position where atmospheric air is prevented from entering the fluid carrying bore. The suction limiting device also includes a valve disposed within the main vent body and positionable between an open position when negative pressure and a closed position when positive pressure exists in the main vent body.

摘要翻译： 具有用于外科系统的具有可变控制的吸力限制装置包括具有延伸穿过其中的流体承载孔的主通气体主体和具有与所述流体承载孔选择性流体连通的主通气口的可变排气机构，以允许引入 大气进入流体承载孔。 排气机构是可调节的，使得进入流体承载孔的气流的程度在完全打开位置到完全关闭位置之间是可变的，其中防止大气空气进入流体承载孔。 吸入限制装置还包括设置在主通风口本体内的阀，并且当在主排气口中存在正压时，可以在负压力的打开位置和关闭位置之间定位。

公开(公告)号：US20060142775A1

公开(公告)日：2006-06-29

申请号：US10905350

申请日：2004-12-29

申请人： Elizabeth Heneberry ,  Kevin Ranucci ,  Jeremy Brown

发明人： Elizabeth Heneberry ,  Kevin Ranucci ,  Jeremy Brown

IPC分类号： A61B17/16

CPC分类号： A61B17/32002 ,  A61B17/1615 ,  A61B17/1633 ,  A61B17/1637 ,  A61B2017/1602 ,  A61B2217/005

摘要： Various methods and devices are provided for cutting and sculpting body tissue, such as cartilage and the like, during a surgical procedure. In an exemplary embodiment, a surgical cutting device is provided which includes an elongate shaft and a rotatable tissue-affecting tip disposed at the distal end thereof. A lumen extends through both the shaft and the tip, and terminates in an opening formed in a distal end of the tissue-affecting tip.

摘要翻译： 提供了各种方法和装置，用于在手术过程中切割和雕刻身体组织，例如软骨等。 在一个示例性实施例中，提供了一种外科切割装置，其包括细长轴和设置在其远端处的可旋转的组织影响尖端。 内腔延伸穿过轴和尖端，并终止于形成在组织影响尖端的远端的开口。

公开(公告)号：US20060129086A1

公开(公告)日：2006-06-15

申请号：US10905044

申请日：2004-12-13

申请人： Ian McRury ,  Mehmet Sengun ,  Kevin Ranucci ,  Douglas Dunn

发明人： Ian McRury ,  Mehmet Sengun ,  Kevin Ranucci ,  Douglas Dunn

IPC分类号： A61B17/20

CPC分类号： A61B17/3203 ,  A61B17/32037

摘要： Various surgical fluid jet cutting instruments for selective bulk removal and precision sculpting of tissue are provided. In one exemplary embodiment, the instrument can include a fluid delivery tube having a nozzle for forming a high pressure fluid jet, and at least two evacuation tubes that are adapted to be selectively and removably coupled to the fluid delivery tube. Each evacuation tube can have an evacuation port or jet-receiving opening that is adapted to be positioned opposite to and spaced apart from the nozzle for receiving the high pressure fluid jet. Each evacuation tube can also be adapted for a specific use. For example, the instrument can include a first evacuation tube that is adapted to allow bulk removal of tissue, and a second evacuation tube that is adapted to allow precision sculpting of tissue.

摘要翻译： 提供了用于选择性散装移除和组织精确雕刻的各种手术流体射流切割仪器。 在一个示例性实施例中，仪器可以包括具有用于形成高压流体射流的喷嘴的流体输送管，以及适于选择性地和可移除地联接到流体输送管的至少两个抽气管。 每个排气管可以具有排气口或喷射接收开口，其适于被定位成与喷嘴相对并间隔开以接收高压流体射流。 每个疏散管也可以适用于特定用途。 例如，仪器可以包括适于允许大量去除组织的第一抽空管，以及适于允许组织精确雕刻的第二抽空管。

公开(公告)号：US06695782B2

公开(公告)日：2004-02-24

申请号：US09975725

申请日：2001-10-11

申请人： Kevin Ranucci ,  Robert A. Rabiner ,  Bradley A. Hare ,  Mark J. Varady ,  Rebecca I. Marciante ,  Roy Robertson

发明人： Kevin Ranucci ,  Robert A. Rabiner ,  Bradley A. Hare ,  Mark J. Varady ,  Rebecca I. Marciante ,  Roy Robertson

IPC分类号： A61N700

CPC分类号： A61B17/320068 ,  A61B17/22012 ,  A61B2017/00137 ,  A61B2017/00274 ,  A61B2017/00477 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61B2017/22018 ,  A61B2017/320084 ,  A61B2018/00547 ,  A61N7/022 ,  A61N2007/0008

摘要： An ultrasonic tissue ablation device comprising a transversely vibrating elongated probe, and a coupling assembly for probe attachment detachment that enables the probe assembly and separation from the device body that includes the ultrasound energy source and a sound conductor, and a method of use for removal of vascular occlusions in blood vessels. The coupling assembly enables incorporation of elongated probes with small cross sectional lumens such as a catheter guidewires. The probe detachability allows insertion manipulation and withdrawal independently of the device body. The probe can be used with acoustic and/or aspirations sheaths to enhance destruction and removal of an occlusion. The horn assembly of the device that contains a sound conducting horn functions as an energy regulator and reservoir for the probe, and precludes loss of probe cavitation energy by its bending or damping within the blood vessel.

摘要翻译： 一种超声波组织消融装置，其包括横向振动的细长探针和用于探针附接分离的联接组件，其使探针组装和分离从包括超声波能量的装置主体和声导体，以及用于去除 血管中的血管闭塞。 联接组件使得能够结合具有小横截面流明的细长探针，例如导管导丝。 探头可拆卸性允许独立于设备主体的插入操作和取出。 探头可以与声学和/或吸气鞘一起使用，以增强咬合的破坏和去除。 包含传导喇叭的装置的喇叭组件用作探针的能量调节器和储存器，并且通过其在血管内的弯曲或阻尼来排除探针空化能量的损失。

公开(公告)号：US08870788B2

公开(公告)日：2014-10-28

申请号：US13168160

申请日：2011-06-24

申请人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

发明人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

IPC分类号： A61B10/02 ,  G01F22/00 ,  G01F23/00 ,  A61B17/16 ,  A61B17/32 ,  A61B10/00 ,  A61B19/00

CPC分类号： A61B10/025 ,  A61B10/0096 ,  A61B10/0266 ,  A61B10/0283 ,  A61B17/1635 ,  A61B17/32002 ,  A61B2017/320064 ,  A61B2090/0807

摘要： Methods and device for extracting and collecting tissue, which can be used for example in tissue engineering and grafting applications, are disclosed. In one embodiment, a device can include an outer tube. A rotatable shaft can be disposed within the outer tube can have a tissue harvesting tip formed on its distal end, the tissue harvesting tip being effective to excise tissue upon rotation thereof. A tissue collection device can be included to receive and collected excised tissue, and the tissue collection device can indicate the amount of tissue collected therein. For example, the tissue collection device can include a straining element which collects excised tissue and an indicator by which to assess the amount of collected tissue. In some embodiments, the tissue collection device can translate to indicate the amount of collected tissue. In many cases, devices disclosed herein can include driving mechanisms that are adapted to drive a tissue harvesting tip such that the tip excises soft tissue, but stops when contacting bone (or soon after contacting bone). In some embodiments, the tissue harvesting tip can be effective to excise viable tissue samples, such that the samples can exhibit desirable proportions of viable cells. Further, in some embodiments, the tissue harvesting tips can excise a tissue sample with tissue particles falling in certain size ranges.

摘要翻译： 公开了用于提取和收集组织的方法和装置，其可以用于组织工程和移植应用中。 在一个实施例中，装置可以包括外管。 旋转轴可以设置在外管内，可以具有形成在其远端上的组织收集尖端，组织收集尖端有效地在旋转时切除组织。 可以包括组织收集装置以接收和收集切除的组织，并且组织收集装置可以指示其中收集的组织的量。 例如，组织收集装置可以包括收集切除的组织的应变元件和用于评估收集的组织的量的指示器。 在一些实施例中，组织收集装置可以平移以指示收集的组织的量。 在许多情况下，本文公开的装置可以包括适于驱动组织收集尖端的驱动机构，使得尖端切除软组织，但是当接触骨骼时（或者在接触骨骼之后不久）停止。 在一些实施方案中，组织采集尖端可有效地切除活组织样品，使得样品可以显示出所需比例的活细胞。 此外，在一些实施例中，组织采集尖端可以用落在一定尺寸范围内的组织颗粒来切除组织样本。

公开(公告)号：US20110257557A1

公开(公告)日：2011-10-20

申请号：US13168160

申请日：2011-06-24

申请人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

发明人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

IPC分类号： A61B10/02

CPC分类号： A61B10/025 ,  A61B10/0096 ,  A61B10/0266 ,  A61B10/0283 ,  A61B17/1635 ,  A61B17/32002 ,  A61B2017/320064 ,  A61B2090/0807

摘要： Methods and device for extracting and collecting tissue, which can be used for example in tissue engineering and grafting applications, are disclosed. In one embodiment, a device can include an outer tube. A rotatable shaft can be disposed within the outer tube can have a tissue harvesting tip formed on its distal end, the tissue harvesting tip being effective to excise tissue upon rotation thereof. A tissue collection device can be included to receive and collected excised tissue, and the tissue collection device can indicate the amount of tissue collected therein. For example, the tissue collection device can include a straining element which collects excised tissue and an indicator by which to assess the amount of collected tissue. In some embodiments, the tissue collection device can translate to indicate the amount of collected tissue. In many cases, devices disclosed herein can include driving mechanisms that are adapted to drive a tissue harvesting tip such that the tip excises soft tissue, but stops when contacting bone (or soon after contacting bone). In some embodiments, the tissue harvesting tip can be effective to excise viable tissue samples, such that the samples can exhibit desirable proportions of viable cells. Further, in some embodiments, the tissue harvesting tips can excise a tissue sample with tissue particles falling in certain size ranges.

摘要翻译： 公开了用于提取和收集组织的方法和装置，其可以用于组织工程和移植应用中。 在一个实施例中，装置可以包括外管。 旋转轴可以设置在外管内，可以具有形成在其远端上的组织收集尖端，组织收集尖端有效地在旋转时切除组织。 可以包括组织收集装置以接收和收集切除的组织，并且组织收集装置可以指示其中收集的组织的量。 例如，组织收集装置可以包括收集切除的组织的应变元件和用于评估收集的组织的量的指示器。 在一些实施例中，组织收集装置可以平移以指示收集的组织的量。 在许多情况下，本文公开的装置可以包括适于驱动组织收集尖端的驱动机构，使得尖端切除软组织，但是当接触骨骼时（或者在接触骨骼之后不久）停止。 在一些实施方案中，组织采集尖端可有效地切除活组织样品，使得样品可以显示出所需比例的活细胞。 此外，在一些实施例中，组织采集尖端可以用落在一定尺寸范围内的组织颗粒来切除组织样本。

公开(公告)号：US20080234715A1

公开(公告)日：2008-09-25

申请号：US12056637

申请日：2008-03-27

申请人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

发明人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

IPC分类号： A61B17/32

CPC分类号： A61B10/025 ,  A61B10/0096 ,  A61B10/0266 ,  A61B10/0283 ,  A61B17/1635 ,  A61B17/32002 ,  A61B2017/320064 ,  A61B2090/0807

摘要： Methods and device for extracting and collecting tissue, which can be used for example in tissue engineering and grafting applications, are disclosed. In one embodiment, a device can include an outer tube. A rotatable shaft can be disposed within the outer tube can have a tissue harvesting tip formed on its distal end, the tissue harvesting tip being effective to excise tissue upon rotation thereof A tissue collection device can be included to receive and collected excised tissue, and the tissue collection device can indicate the amount of tissue collected therein. For example, the tissue collection device can include a straining element which collects excised tissue and an indicator by which to assess the amount of collected tissue. In some embodiments, the tissue collection device can translate to indicate the amount of collected tissue. In many cases, devices disclosed herein can include driving mechanisms that are adapted to drive a tissue harvesting tip such that the tip excises soft tissue, but stops when contacting bone (or soon after contacting bone). In some embodiments, the tissue harvesting tip can be effective to excise viable tissue samples, such that the samples can exhibit desirable proportions of viable cells. Further, in some embodiments, the tissue harvesting tips can excise a tissue sample with tissue particles falling in certain size ranges.

摘要翻译： 公开了用于提取和收集组织的方法和装置，其可以用于组织工程和移植应用中。 在一个实施例中，装置可以包括外管。 旋转轴可以设置在外管内，可以具有形成在其远端上的组织收集尖端，组织收集尖端有效地在旋转时切除组织。可以包括组织收集装置以接收和收集切除的组织，并且 组织收集装置可以指示其中收集的组织的量。 例如，组织收集装置可以包括收集切除的组织的应变元件和用于评估收集的组织的量的指示器。 在一些实施例中，组织收集装置可以平移以指示收集的组织的量。 在许多情况下，本文公开的装置可以包括适于驱动组织收集尖端的驱动机构，使得尖端切除软组织，但是当接触骨骼时（或者在接触骨骼之后不久）停止。 在一些实施方案中，组织采集尖端可有效地切除活组织样品，使得样品可以显示出所需比例的活细胞。 此外，在一些实施例中，组织采集尖端可以用落在一定尺寸范围内的组织颗粒来切除组织样本。

公开(公告)号：US20070173873A1

公开(公告)日：2007-07-26

申请号：US11307121

申请日：2006-01-24

申请人： Kevin Ranucci ,  Mehmet Sengun

发明人： Kevin Ranucci ,  Mehmet Sengun

IPC分类号： A61B17/32

CPC分类号： A61B17/32002 ,  A61B2017/00539 ,  A61B2017/00553 ,  A61B2017/320032 ,  F16D57/02

摘要： Systems and methods are provided for passively dissipating a rotational speed of a fluid-driven rotatable shaft. In particular, a dissipation member is provided for dissipating the rotational speed of a shaft having an end effector formed thereon. As the rotational speed of the shaft increases, the dissipation member will apply a counter-torque to the shaft, thereby limiting the rotational speed of the shaft. In an exemplary embodiment, the counter-torque has a non-linear dependence on the rotational speed of the shaft, such that the counter-torque increases at a rate greater than a rate of increase in the rotational speed. Thus, when the end effector of the rotatable shaft is placed in contact with tissue and the operational speed of the shaft is reduced, the dissipation member will apply a minimal or low counter-torque to the rotatable shaft. When the end effector of the rotatable shaft is removed from the tissue and the operational speed of the shaft increases, the counter-torque applied by the dissipation member will increase thereby limiting the operational speed of the shaft.

摘要翻译： 提供了用于被动地耗散流体驱动的可旋转轴的转速的系统和方法。 特别地，提供了用于消散其上形成有末端执行器的轴的旋转速度的散开构件。 当轴的旋转速度增加时，散开构件将向轴施加反扭矩，从而限制轴的旋转速度。 在示例性实施例中，反扭矩对轴的转速具有非线性依赖性，使得反扭矩以大于转速增加速率的速率增加。 因此，当可旋转轴的末端执行器被放置成与组织接触并且轴的操作速度减小时，散开构件将向可旋转轴施加最小或低的反向扭矩。 当可旋转轴的端部执行器从组织移除并且轴的操作速度增加时，由散热构件施加的反扭矩将增加，从而限制轴的操作速度。

公开(公告)号：US20060142773A1

公开(公告)日：2006-06-29

申请号：US10905351

申请日：2004-12-29

申请人： Mehmet Sengun ,  Elizabeth Heneberry ,  Ian McRury ,  Kevin Ranucci ,  Douglas Dunn

发明人： Mehmet Sengun ,  Elizabeth Heneberry ,  Ian McRury ,  Kevin Ranucci ,  Douglas Dunn

IPC分类号： A61B17/16

CPC分类号： A61B17/3203 ,  A61B17/1644 ,  A61B17/32037 ,  A61B2017/1648

摘要： A high pressure fluid jet system is provided, which is useful for cutting hard material during a surgical procedure. The cutting of hard material is more efficient as the system delivers abrasive solid particles with the high pressure fluid. In an exemplary embodiment, abrasive solid particles can be mixed with a pressurized stream of fluid prior to delivery of the fluid to a nozzle of an application tool. Alternatively, the abrasive solid particles can be entrained in the pressurized fluid stream or the pressurized fluid stream can erode a solid or suspension form of the abrasive particles.

摘要翻译： 提供了一种高压流体喷射系统，可用于在外科手术过程中切割硬质材料。 硬质材料的切割更有效，因为系统用高压流体输送磨料固体颗粒。 在示例性实施例中，在将流体输送到施加工具的喷嘴之前，磨料固体颗粒可与加压流体流混合。 或者，磨料固体颗粒可以夹带在加压流体流中，或者加压流体流可以侵蚀固体或悬浮​​液形式的磨料颗粒。