公开(公告)号：US06730048B1

公开(公告)日：2004-05-04

申请号：US10328202

申请日：2002-12-23

申请人： Bradley A. Hare ,  Janniah S. Prasad

发明人： Bradley A. Hare ,  Janniah S. Prasad

IPC分类号： A61B1722

CPC分类号： A61B17/22012 ,  A61B90/39 ,  A61B2017/00902 ,  A61B2017/22014 ,  A61B2017/22018 ,  A61B2090/3925

摘要： The present invention provides an apparatus and method for an ultrasonic medical device with improved visibility in imaging procedures. A medical device comprises an elongated probe having a material of high radiopacity at an at least one predetermined location of the probe wherein the material of high radiopacity is capable of withstanding series of vibrations of the elongated probe. The material of high radiopacity allows the elongated probe to be visualized in imaging procedures when the probe is inserted into a body. The present invention provides a method of improving the visibility of an ultrasonic medical device during a medical procedure by engaging a material of high radiopacity to a small diameter elongated probe wherein the material of high radiopacity engages the probe at an at least one predetermined location.

摘要翻译： 本发明提供一种超声波医疗装置的装置和方法，其具有改进的成像过程中的可见性。 医疗装置包括在探针的至少一个预定位置处具有高射线不透性材料的细长探针，其中高不透射线材料能够承受细长探针的一系列振动。 高射线不透射线的材料允许细长的探针在成像过程中可视化，当探针插入体内时。 本发明提供了一种在医疗过程中通过将高辐射不透性材料接合到小直径细长探针来提高超声波医疗装置的可视性的方法，其中高射线不透性材料在至少一个预定位置处接合探针。

公开(公告)号：US06695781B2

公开(公告)日：2004-02-24

申请号：US09917471

申请日：2001-07-27

申请人： Robert A. Rabiner ,  Bradley A. Hare

发明人： Robert A. Rabiner ,  Bradley A. Hare

IPC分类号： A61N700

CPC分类号： A61B17/320068 ,  A61B2017/00137 ,  A61B2017/00274 ,  A61B2017/00477 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61B2017/22018 ,  A61B2017/320084 ,  A61B2018/00547 ,  A61N7/022 ,  A61N2007/0008

摘要： A method for destructing, reducing or removing mammalian tissue with an ultrasonic device IS disclosed, comprising contacting the tissue with a transverse mode ultrasonic probe, and transmitting ultrasonic energy to the probe, until the tissue is fragmented by emulsification. The probe can be used with acoustic and/or aspirations sheaths to enhance destruction and removal of an occlusion and in combination with an imaging device to effect remodeling of human tissue in medical and cosmetic surgical procedures.

摘要翻译： 公开了一种用超声波装置IS破坏，减少或去除哺乳动物组织的方法，包括使组织与横向模式超声波探头接触，并将超声波能量传递给探针，直到组织被乳化分裂为止。 探针可以与声学和/或吸气鞘一起使用以增强咬合的破坏和去除，并与成像装置组合以在医疗和美容外科手术中实现人体组织的重塑。

公开(公告)号：US06527115B2

公开(公告)日：2003-03-04

申请号：US09775908

申请日：2001-02-02

申请人： Robert A. Rabiner ,  Bradley A. Hare ,  James H. Loper

发明人： Robert A. Rabiner ,  Bradley A. Hare ,  James H. Loper

IPC分类号： B65D8310

CPC分类号： B65D43/20 ,  A61B50/30 ,  A61B50/36 ,  A61B2050/0081 ,  A61M5/3213

摘要： The invention is directed to a container for storage, dispensation, transport and disposal of a medical device such a disposable ultrasonic surgical probe, that allows its dispensation for use, and for its safe storage and disposal after use, thereby protecting the user from the hazards of needle pricks and possible contamination from small-diameter probes. The container of the present invention also provides a mechanism for restricting access to the probe to prevent its reuse, and a method for its safe attachment to and detachment from an ultrasonic medical device. The container comprises a cylindrical tube having two ends and an inner surface defining a space for containing the probe. The probe is held within the cylindrical section of the container by a locking means that allows a single dispensation for its use and enables its disposal after use in an inaccessible manner, so as to enable its attachment and detachment to the non-disposable segment of the device such as an ultrasonic probe handle without requiring direct handling by the user. The user, is therefore protected from against accidental sticks from a possibly contaminated probe. The container also prevents re-use of the probe, and provides a means for its safe disposal.

公开(公告)号：US20100331743A1

公开(公告)日：2010-12-30

申请号：US12880821

申请日：2010-09-13

申请人： Robert A. Rabiner ,  Bradley A. Hare ,  Rebecca I. Marciante ,  Mark J. Varady

发明人： Robert A. Rabiner ,  Bradley A. Hare ,  Rebecca I. Marciante ,  Mark J. Varady

IPC分类号： A61N7/00 ,  A61H1/00

CPC分类号： A61B17/22012 ,  A61B2017/22008 ,  A61B2017/320073 ,  A61B2017/320084 ,  A61B2017/320088

摘要： The present invention provides an apparatus and a method for an ultrasonic medical device operating in a torsional mode and a transverse mode. An ultrasonic probe of the ultrasonic medical device is placed in communication with a biological material. An ultrasonic energy source is activated to produce an electrical signal that drives a transducer to produce a torsional vibration of the ultrasonic probe. The torsional vibration produces a component of force in a transverse direction relative to a longitudinal axis of the ultrasonic probe, thereby exciting a transverse vibration along the longitudinal axis causing the ultrasonic probe to undergo both a torsional vibration and a transverse vibration. The torsional vibration and the transverse vibration cause cavitation in a medium surrounding the ultrasonic probe to ablate the biological material.

摘要翻译： 本发明提供一种在扭转模式和横向模式下操作的超声医疗装置的装置和方法。 将超声波医疗装置的超声波探头与生物体材料连通。 激活超声能量源以产生驱动换能器以产生超声波探头的扭转振动的电信号。 扭转振动相对于超声波探头的纵轴在横向上产生力的分量，从而激励沿着纵向轴线的横向振动，使得超声波探头经受扭转振动和横向振动。 扭转振动和横向振动会在超声波探头周围的介质中引起气蚀，以消除生物材料。

公开(公告)号：US07794414B2

公开(公告)日：2010-09-14

申请号：US10774898

申请日：2004-02-09

申请人： Robert A. Rabiner ,  Bradley A. Hare ,  Rebecca I. Marciante ,  Mark J. Varady

发明人： Robert A. Rabiner ,  Bradley A. Hare ,  Rebecca I. Marciante ,  Mark J. Varady

IPC分类号： A61H1/00

CPC分类号： A61B17/22012 ,  A61B2017/22008 ,  A61B2017/320072 ,  A61B2017/320084 ,  A61B2017/320088

摘要： The present invention provides an apparatus and a method for an ultrasonic medical device operating in a torsional mode and a transverse mode. An ultrasonic probe of the ultrasonic medical device is placed in communication with a biological material. An ultrasonic energy source is activated to produce an electrical signal that drives a transducer to produce a torsional vibration of the ultrasonic probe. The torsional vibration produces a component of force in a transverse direction relative to a longitudinal axis of the ultrasonic probe, thereby exciting a transverse vibration along the longitudinal axis causing the ultrasonic probe to undergo both a torsional vibration and a transverse vibration. The torsional vibration and the transverse vibration cause cavitation in a medium surrounding the ultrasonic probe to ablate the biological material.

摘要翻译： 本发明提供一种在扭转模式和横向模式下操作的超声医疗装置的装置和方法。 将超声波医疗装置的超声波探头放置成与生物材料连通。 激活超声能量源以产生驱动换能器以产生超声波探头的扭转振动的电信号。 扭转振动相对于超声波探头的纵轴在横向上产生力的分量，从而激励沿着纵向轴线的横向振动，使得超声波探头经受扭转振动和横向振动。 扭转振动和横向振动会在超声波探头周围的介质中引起气蚀，以消除生物材料。

公开(公告)号：US07503895B2

公开(公告)日：2009-03-17

申请号：US10373134

申请日：2003-02-24

申请人： Robert A. Rabiner ,  Bradley A. Hare

发明人： Robert A. Rabiner ,  Bradley A. Hare

IPC分类号： A61B8/00 ,  A61B8/14

CPC分类号： A61N7/022 ,  A61B17/22012 ,  A61B17/320068 ,  A61B2017/00137 ,  A61B2017/00274 ,  A61B2017/22002 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61B2017/22015 ,  A61B2017/22018 ,  A61B2017/22051 ,  A61B2017/293 ,  A61B2017/320084 ,  A61B2017/320098 ,  A61B2018/00547 ,  A61B2018/00982 ,  A61B2217/005 ,  A61B2217/007 ,  A61M1/0084 ,  A61N2007/0008

摘要： A transverse mode ultrasonic probe is provided which creates a cavitation area along its longitudinal length, increasing the working surface of the probe. Accessory sheaths are also provided for use with the probe to enable a user to select from features most suited to an individual medical procedure. The sheaths provide acoustic enhancing and aspiration enhancing properties, and/or can be used as surgical tools or as medical access devices, protecting tissue from physical contact with the probe.

公开(公告)号：US06733451B2

公开(公告)日：2004-05-11

申请号：US10396914

申请日：2003-03-25

申请人： Robert A. Rabiner ,  Bradley A. Hare ,  Rebecca I. Marciante ,  Elaine S. Buffen ,  Mark R. Gosnell ,  Heather L. Senseney-Mellor

发明人： Robert A. Rabiner ,  Bradley A. Hare ,  Rebecca I. Marciante ,  Elaine S. Buffen ,  Mark R. Gosnell ,  Heather L. Senseney-Mellor

IPC分类号： A61B812

CPC分类号： A61B17/22012 ,  A61B17/320068 ,  A61B2017/00137 ,  A61B2017/00274 ,  A61B2017/22002 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61B2017/22015 ,  A61B2017/22018 ,  A61B2017/320084 ,  A61B2018/00547 ,  A61N7/022

摘要： The present invention provides an apparatus and a method of using an ultrasonic probe with a pharmacological agent to enhance an occlusion treating effect of the ultrasonic probe to effectively remove an occlusion. The pharmacological agent is released through a catheter to treat the occlusion and enhance an effect of a transverse ultrasonic vibration of the ultrasonic probe to effectively remove the occlusion. The pharmacological agent continues to travel downstream of the site of the occlusion and work in conjunction with the ultrasonic probe to reduce the occlusion to a size that can easily be removed from the body naturally in order to prevent reformation of the occlusion and other health risks.

摘要翻译： 本发明提供了一种使用超声波探针与药理学物质来增强超声波探头的闭塞治疗效果以有效去除闭塞的装置和方法。 药物通过导管释放以治疗闭塞并增强超声波探头的横向超声波振动的效果，以有效去除闭塞。 药物剂继续前进到阻塞部位的下游并与超声波探头联合工作，以将阻塞减少到容易从人体中自然除去的尺寸，以防止堵塞的改变和其他健康风险。

公开(公告)号：US20100087759A1

公开(公告)日：2010-04-08

申请号：US12555495

申请日：2009-09-08

申请人： Bradley A. Hare ,  Kyle K. Jarger ,  Charles J. Vadala, JR. ,  Anthony W. O'Leary ,  Thomas A. Murphy ,  Roy M. Robertson

发明人： Bradley A. Hare ,  Kyle K. Jarger ,  Charles J. Vadala, JR. ,  Anthony W. O'Leary ,  Thomas A. Murphy ,  Roy M. Robertson

IPC分类号： A61N7/00

CPC分类号： A61B17/22012 ,  A61B2017/22014 ,  A61B2017/320098

摘要： An apparatus and method for an ultrasonic medical device with a variable frequency drive for ablating a biological material comprises an ultrasonic probe having a proximal end, a distal end and a longitudinal axis therebetween; a transducer that drives the ultrasonic probe over a variable frequency range, creating a transverse ultrasonic vibration along at least a portion of the longitudinal axis of the ultrasonic probe; a coupling engaging the proximal end of the ultrasonic probe to a distal end of the transducer; and an ultrasonic energy source engaged to the transducer that produces an ultrasonic energy, wherein driving the ultrasonic probe over the variable frequency range allows for the ultrasonic energy to propagate around a bend of the ultrasonic probe to ablate the biological material in communication with the ultrasonic probe.

摘要翻译： 一种具有用于烧蚀生物材料的变频驱动器的超声波医疗装置的装置和方法包括：超声波探头，其具有近端，远端和在其间的纵向轴线; 换能器，其在可变频率范围内驱动超声波探头，沿着超声波探头的纵轴的至少一部分产生横向超声波振动; 将所述超声波探头的近端接合到所述换能器的远端的联接器; 以及接合到所述换能器的超声波能源，其产生超声波能量，其中在所述可变频率范围上驱动所述超声波探头允许所述超声能量围绕所述超声波探头的弯曲部传播以消融与所述超声波探头连通的所述生物材料 。

公开(公告)号：US07494468B2

公开(公告)日：2009-02-24

申请号：US10371781

申请日：2003-02-21

申请人： Robert A. Rabiner ,  Bradley A. Hare ,  David M. Fischer ,  Andy Levine

发明人： Robert A. Rabiner ,  Bradley A. Hare ,  David M. Fischer ,  Andy Levine

IPC分类号： A61B8/00 ,  A61B17/32

CPC分类号： A61N7/022 ,  A61B17/22012 ,  A61B17/320068 ,  A61B2017/00137 ,  A61B2017/00274 ,  A61B2017/22002 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61B2017/22015 ,  A61B2017/22018 ,  A61B2017/22051 ,  A61B2017/293 ,  A61B2017/320084 ,  A61B2018/00547 ,  A61B2018/00982 ,  A61B2217/005 ,  A61B2217/007 ,  A61N2007/0008

摘要： An ultrasonic medical device comprises an ultrasonic vibration generator that generates vibration along its longitudinal axis. The ultrasonic vibration is transmitted through an ultrasonic coupler and a series of transformer sections that amplify the ultrasonic vibration. A flexible member is coupled to the distal end of the transformer sections, and is thus supplied with a longitudinal vibration at its base by the transformer sections. The flexible member is designed so that it converts the longitudinal vibration into a standing wave that runs along the length of the flexible member. The standing wave produces a series of nodes and anti-nodes along the length of the flexible member. Each of the anti-nodes produces cavitation in fluids in contact with the probe. The cavitation of the fluids causes destruction of adjacent tissue. In this manner, the entire length of the flexible member becomes a working surface that may be utilized for destroying tissue.

摘要翻译： 超声波医疗装置包括沿其纵向轴线产生振动的超声波振动发生器。 超声波振动通过超声波耦合器和一系列扩大超声波振动的变压器部分传播。 柔性构件联接到变压器部分的远端，并且因此在其底部由变压器部分提供纵向振动。 柔性构件被设计成使得其将纵向振动转换成沿着柔性构件的长度延伸的驻波。 驻波在柔性构件的长度上产生一系列节点和反节点。 每个反节点在与探针接触的流体中产生气蚀。 流体的气蚀导致相邻组织的破坏。 以这种方式，柔性构件的整个长度变成可用于破坏组织的工作表面。

公开(公告)号：US06695782B2

公开(公告)日：2004-02-24

申请号：US09975725

申请日：2001-10-11

申请人： Kevin Ranucci ,  Robert A. Rabiner ,  Bradley A. Hare ,  Mark J. Varady ,  Rebecca I. Marciante ,  Roy Robertson

发明人： Kevin Ranucci ,  Robert A. Rabiner ,  Bradley A. Hare ,  Mark J. Varady ,  Rebecca I. Marciante ,  Roy Robertson

IPC分类号： A61N700

CPC分类号： A61B17/320068 ,  A61B17/22012 ,  A61B2017/00137 ,  A61B2017/00274 ,  A61B2017/00477 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61B2017/22018 ,  A61B2017/320084 ,  A61B2018/00547 ,  A61N7/022 ,  A61N2007/0008

摘要： An ultrasonic tissue ablation device comprising a transversely vibrating elongated probe, and a coupling assembly for probe attachment detachment that enables the probe assembly and separation from the device body that includes the ultrasound energy source and a sound conductor, and a method of use for removal of vascular occlusions in blood vessels. The coupling assembly enables incorporation of elongated probes with small cross sectional lumens such as a catheter guidewires. The probe detachability allows insertion manipulation and withdrawal independently of the device body. The probe can be used with acoustic and/or aspirations sheaths to enhance destruction and removal of an occlusion. The horn assembly of the device that contains a sound conducting horn functions as an energy regulator and reservoir for the probe, and precludes loss of probe cavitation energy by its bending or damping within the blood vessel.

摘要翻译： 一种超声波组织消融装置，其包括横向振动的细长探针和用于探针附接分离的联接组件，其使探针组装和分离从包括超声波能量的装置主体和声导体，以及用于去除 血管中的血管闭塞。 联接组件使得能够结合具有小横截面流明的细长探针，例如导管导丝。 探头可拆卸性允许独立于设备主体的插入操作和取出。 探头可以与声学和/或吸气鞘一起使用，以增强咬合的破坏和去除。 包含传导喇叭的装置的喇叭组件用作探针的能量调节器和储存器，并且通过其在血管内的弯曲或阻尼来排除探针空化能量的损失。