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公开(公告)号：US20070244054A1
公开(公告)日：2007-10-18
申请号：US11268268
申请日：2005-11-07
申请人： Ulrich Sensfuss , Kilian Conde Frieboes , Leif Christensen , Ingrid Petterson , Thomas Hansen , Michael Ankersen , Kjeld Madsen
发明人： Ulrich Sensfuss , Kilian Conde Frieboes , Leif Christensen , Ingrid Petterson , Thomas Hansen , Michael Ankersen , Kjeld Madsen
摘要： Novel cyclic and linear peptides of the formula R1—X—X1—X2—X3—X4—X5—X6—X7—X8—X9—X10—X11—R2 are useful in the treatment of obesity are provided.
摘要翻译： 新型的具有式R 1至X 2的环状和线性肽-X -X 2 -X 3 -X 3 - 第4〜第5至第六至第六至第七至第十七至第十七 另外还提供了用于治疗肥胖症的SUP＃9 - 10 - 10 - 11 - 2 - 2。
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公开(公告)号：US20070027091A1
公开(公告)日：2007-02-01
申请号：US11278014
申请日：2006-03-30
申请人： Kilian Conde-Frieboes , Ulrich Sensfuss , Kjeld Madsen , Nils Johansen , Leif Christensen , Thomas Hansen , Birgitte Wulff
发明人： Kilian Conde-Frieboes , Ulrich Sensfuss , Kjeld Madsen , Nils Johansen , Leif Christensen , Thomas Hansen , Birgitte Wulff
摘要： Small cyclic peptides of the formula X1-X2-X3-X4-X5-X6-X7-R1 comprising 7-12 amino acid residues are provided. Said peptides are MC4 receptor agonists, and thus useful in the treatment of obesity and related diseases.
摘要翻译： 提供了包含7-12个氨基酸残基的式X1-X2-X3-X4-X5-X6-X7-R-1的小环肽。 所述肽是MC4受体激动剂，因此可用于治疗肥胖症和相关疾病。
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公开(公告)号：US20080039387A1
公开(公告)日：2008-02-14
申请号：US11666799
申请日：2005-11-04
CPC分类号： C07K14/68
摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.
摘要翻译： 本发明涉及有效调节一种或多种黑皮质素受体类型的新型肽化合物，治疗中化合物的用途，包括向有需要的患者施用化合物的治疗方法，以及使用 药物制造中的化合物。 本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病症方面特别有意义。
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公开(公告)号：US20070185128A1
公开(公告)日：2007-08-09
申请号：US10719110
申请日：2003-11-21
申请人： Kilian Conde-Frieboes , Michael Ankersen , Ulrich Sensfuss , Birgitte Wulff , Henning Thogersen , Philipp Lustenberger , Klaus Rudolf , Bernd Krist , Stephan Muller , Dirk Stenkamp , Marcus Schindler , Heike Wieland , Kirsten Arndt
发明人： Kilian Conde-Frieboes , Michael Ankersen , Ulrich Sensfuss , Birgitte Wulff , Henning Thogersen , Philipp Lustenberger , Klaus Rudolf , Bernd Krist , Stephan Muller , Dirk Stenkamp , Marcus Schindler , Heike Wieland , Kirsten Arndt
IPC分类号： C07D403/06 , A61K31/4965 , A61K31/497 , C07D241/04
CPC分类号： C07D401/06 , C07D241/08 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/14
摘要： Described herein are novel and useful compounds of the general formula Compounds of this invention can advantageously exhibit melanocortin receptor agonist activity. New and useful compounds comprising such a chemical structure and methods of modulating melanocortin receptor activity in a subject (and promoting, inducing, and/or enhancing the treatment or prevention of related diseases) by administering such a compound or composition also are described.
摘要翻译： 本文描述的是新颖且有用的通式化合物本发明的化合物可以有利地显示黑皮质素受体激动剂活性。 还描述了通过施用这种化合物或组合物，包含这种化学结构和调节受试者中黑皮质素受体活性的方法（以及促进，诱导和/或增强相关疾病的治疗或预防）的新型有用化合物。
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