公开(公告)号：US09920084B2

公开(公告)日：2018-03-20

申请号：US14240067

申请日：2012-08-23

申请人： Masad J. Damha ,  Matthew Hassler ,  Tak-Hang Chan ,  Mallikarjuna Reddy Nandyala ,  Robert Alexander Donga

发明人： Masad J. Damha ,  Matthew Hassler ,  Tak-Hang Chan ,  Mallikarjuna Reddy Nandyala ,  Robert Alexander Donga

IPC分类号： C07D233/60 ,  C07D333/00 ,  C40B80/00 ,  C07F9/54 ,  C07H19/02 ,  C07H21/00 ,  C07F9/655 ,  C07F9/6558 ,  C07H21/02 ,  C40B50/16

CPC分类号： C07F9/54 ,  C07D233/60 ,  C07F9/5407 ,  C07F9/5442 ,  C07F9/5456 ,  C07F9/65515 ,  C07F9/65586 ,  C07H19/02 ,  C07H21/00 ,  C07H21/02 ,  C40B50/16 ,  C40B80/00

摘要： The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

公开(公告)号：US20140256926A1

公开(公告)日：2014-09-11

申请号：US14240067

申请日：2012-08-23

申请人： Masad J. Damha ,  Matthew Hassler ,  Tak-Hang Chan ,  Mallikarjuna Reddy Nandyala ,  Robert Alexander Donga

发明人： Masad J. Damha ,  Matthew Hassler ,  Tak-Hang Chan ,  Mallikarjuna Reddy Nandyala ,  Robert Alexander Donga

IPC分类号： C07H21/02 ,  C07F9/54

CPC分类号： C07F9/54 ,  C07D233/60 ,  C07F9/5407 ,  C07F9/5442 ,  C07F9/5456 ,  C07F9/65515 ,  C07F9/65586 ,  C07H19/02 ,  C07H21/00 ,  C07H21/02 ,  C40B50/16 ,  C40B80/00

摘要： The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

摘要翻译： 本发明涉及寡核苷酸的化学合成，例如寡核糖核苷酸。 另一方面，本发明涉及制备这些化合物的式（II）化合物及其在寡核苷酸的化学合成中的用途，例如寡核糖核苷酸。 本发明还涉及低聚物的合成方法，所述寡聚物包括但不限于在本文提供的方法中使用的溶液体系中的寡肽，寡糖和寡核苷酸，特别是寡核糖核苷酸和寡脱氧核糖核苷酸，以及离子标签接头。