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公开(公告)号：US20140256926A1
公开(公告)日：2014-09-11
申请号：US14240067
申请日：2012-08-23
申请人： Masad J. Damha , Matthew Hassler , Tak-Hang Chan , Mallikarjuna Reddy Nandyala , Robert Alexander Donga
发明人： Masad J. Damha , Matthew Hassler , Tak-Hang Chan , Mallikarjuna Reddy Nandyala , Robert Alexander Donga
CPC分类号： C07F9/54 , C07D233/60 , C07F9/5407 , C07F9/5442 , C07F9/5456 , C07F9/65515 , C07F9/65586 , C07H19/02 , C07H21/00 , C07H21/02 , C40B50/16 , C40B80/00
摘要： The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
摘要翻译： 本发明涉及寡核苷酸的化学合成，例如寡核糖核苷酸。 另一方面，本发明涉及制备这些化合物的式（II）化合物及其在寡核苷酸的化学合成中的用途，例如寡核糖核苷酸。 本发明还涉及低聚物的合成方法，所述寡聚物包括但不限于在本文提供的方法中使用的溶液体系中的寡肽，寡糖和寡核苷酸，特别是寡核糖核苷酸和寡脱氧核糖核苷酸，以及离子标签接头。
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公开(公告)号：US09920084B2
公开(公告)日：2018-03-20
申请号：US14240067
申请日：2012-08-23
申请人： Masad J. Damha , Matthew Hassler , Tak-Hang Chan , Mallikarjuna Reddy Nandyala , Robert Alexander Donga
发明人： Masad J. Damha , Matthew Hassler , Tak-Hang Chan , Mallikarjuna Reddy Nandyala , Robert Alexander Donga
IPC分类号： C07D233/60 , C07D333/00 , C40B80/00 , C07F9/54 , C07H19/02 , C07H21/00 , C07F9/655 , C07F9/6558 , C07H21/02 , C40B50/16
CPC分类号： C07F9/54 , C07D233/60 , C07F9/5407 , C07F9/5442 , C07F9/5456 , C07F9/65515 , C07F9/65586 , C07H19/02 , C07H21/00 , C07H21/02 , C40B50/16 , C40B80/00
摘要： The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
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公开(公告)号：US10059736B2
公开(公告)日：2018-08-28
申请号：US11908487
申请日：2006-03-15
申请人： Tak-Hang Chan , Masad J. Damha , Weishi Miao , Robert Alexander Donga , Xun He
发明人： Tak-Hang Chan , Masad J. Damha , Weishi Miao , Robert Alexander Donga , Xun He
CPC分类号： C07H21/00 , C07H3/06 , C07K1/023 , C07K1/04 , Y02P20/542
摘要： The present invention relates to ionic liquids for use in chemical applications and capable of serving the dual function of solvent and liquid support. The ionic liquid lends itself to a method of synthesizing oligomers selected from the group consisting of oligopeptides, oligosaccharides and oligonucleotides, comprising contacting a first monomer unit with an ionic liquid at reaction conditions to provide an ionic liquid bound monomer unit; and contacting the ionic liquid bound monomer unit with at least one further monomer unit at reaction conditions to provide an ionic liquid bound oligomer comprising from 2 to 30 monomer units. The method lends itself to large scale manufacture of oligopeptides, oligosaccharides and oligonucleotides.
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公开(公告)号：US20100041869A1
公开(公告)日：2010-02-18
申请号：US11908487
申请日：2006-03-15
申请人： Tak-Hang Chan , Masad J. Damha , Weishi Miao , Robert Alexander Donga , Xun He
发明人： Tak-Hang Chan , Masad J. Damha , Weishi Miao , Robert Alexander Donga , Xun He
CPC分类号： C07H21/00 , C07H3/06 , C07K1/023 , C07K1/04 , Y02P20/542
摘要： The present invention relates to ionic liquids for use in chemical applications and capable of serving the dual function of solvent and liquid support. The ionic liquid lends itself to a method of synthesizing oligomers selected from the group consisting of oligopeptides, oligosaccharides and oligonucleotides, comprising contacting a first monomer unit with an ionic liquid at reaction conditions to provide an ionic liquid bound monomer unit; and contacting the ionic liquid bound monomer unit with at least one further monomer unit at reaction conditions to provide an ionic liquid bound oligomer comprising from 2 to 30 monomer units. The method lends itself to large scale manufacture of oligopeptides, oligosaccharides and oligonucleotides.
摘要翻译： 本发明涉及用于化学应用并能够起到溶剂和液体载体的双重作用的离子液体。 离子液体本身适用于合成选自寡肽，寡糖和寡核苷酸的低聚物的方法，包括在反应条件下使第一单体单元与离子液体接触以提供离子液体结合的单体单元; 以及在反应条件下使离子液体结合的单体单元与至少一个其它单体单元接触，以提供包含2至30个单体单元的离子液体结合的低聚物。 该方法适合大规模生产寡肽，寡糖和寡核苷酸。
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