公开(公告)号：US20080206248A1

公开(公告)日：2008-08-28

申请号：US11699214

申请日：2007-01-29

Applicant: Michael Stratton ,  Andrew Futreal ,  Richard Wooster

Inventor： Michael Stratton ,  Andrew Futreal ,  Richard Wooster

IPC: A61K39/395 ,  C12N9/12 ,  C07H21/04 ,  C07K16/40 ,  C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/57492 ,  C07K14/475 ,  G01N33/5011 ,  G01N2333/485 ,  G01N2333/71

Abstract: The invention relates to mutations in ErbB2 gene products. The mutations described are identified in human tumours of natural origin. These mutations are associated with cancerous phenotypes and can be used as a basis for the diagnosis of cancer, cancerous cells or a predisposition to cancer in human subjects, selection of appropriate anti-cancer therapy and the development of anti-cancer therapeutics.

Abstract translation: 本发明涉及ErbB2基因产物中的突变。 所描述的突变在天然来源的人类肿瘤中鉴定。 这些突变与癌症表型相关，可用作诊断癌症，癌细胞或人类受试者癌症倾向的基础，选择合适的抗癌治疗和抗癌治疗的发展。

公开(公告)号：US4986167A

公开(公告)日：1991-01-22

申请号：US356489

申请日：1989-05-25

Applicant: Michael Stratton ,  Clifford O. Jeske

Inventor： Michael Stratton ,  Clifford O. Jeske

IPC: F01M1/08 ,  F01P3/10 ,  F01P3/18 ,  F02B3/06 ,  F02B23/06 ,  F02F3/00 ,  F02F3/22

CPC classification number: F01P3/18 ,  F02B23/0696 ,  F02F3/0069 ,  F02F3/22 ,  F01M2001/086 ,  F02B3/06 ,  F02F2003/0061 ,  F02F2200/04 ,  F05C2201/021 ,  F05C2201/0448 ,  Y02T10/125

Abstract: The design and construction of past articulated pistons has failed to include the most efficient cooling reservoir for transferring heat from the piston to the coolant. The present invention overcomes these problems by using an annular cooling recess of a precisely defined cross sectional shape and volume and a baffle plate fixedly sealingly attached in heat conducting relationship to the piston member to form a cooling gallery. The baffle plate has an opening therein and an upwardly extending raised portion to preestablish a trapped volume of coolant therein. The assembly, positioning of the plate and the preestablished trapped volume insures high efficiency of the coolant to absorb heat through the scrubbing action of the coolant on the recess and the heat absorbed by the trapped coolant because of the heat conducting relationship of the plate and the piston member.

Abstract translation: 过去的铰接活塞的设计和结构未能包括用于将热量从活塞传递到冷却剂的最有效的冷却储存器。 本发明通过使用精确限定的横截面形状和体积的环形冷却凹部和与活塞构件以热传导关系固定地密封地附接的挡板形成冷却槽来克服这些问题。 挡板在其中具有开口，并且具有向上延伸的凸起部分以预先建立其中的被捕获的体积的冷却剂。 板的组装，定位和预先建立的被捕获的体积确保了冷却剂的高效率，以通过冷却剂在凹部上的擦洗作用吸收热量以及被捕获的冷却剂吸收的热量，因为板和热板的热传导关系 活塞构件。