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公开(公告)号：US07341739B2
公开(公告)日：2008-03-11
申请号：US10842977
申请日：2004-05-11
申请人： Beppino C. Giovanella , J. Vernon Knight , J. Clifford Waldrep , Nadezhda Koshkina , Brian Gilbert , Clyde W. Wellen
发明人： Beppino C. Giovanella , J. Vernon Knight , J. Clifford Waldrep , Nadezhda Koshkina , Brian Gilbert , Clyde W. Wellen
IPC分类号： A61K31/4745 , A61K9/14
CPC分类号： A61K9/0078 , A61K9/127 , A61K31/03 , A61K31/175 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/7048 , A61K38/21 , Y10S514/938
摘要： The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
摘要翻译： 小颗粒脂质体气溶胶化合物和本发明的治疗方法涉及掺入脂质体的脂质或水溶性抗癌药物。 脂质体在水分散体中从喷雾器喷射到个体的呼吸道。 可以使用各种抗癌药物，包括20-S-喜树碱，9-硝基喜树碱，9-氨基喜树碱，10,11-亚甲二氧基喜树碱和紫杉醇或其衍生物。 通过吸入给药这些药物比肌肉内给药或口服给药提供更快更有效的抗癌药物吸收。
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公开(公告)号：US20080008662A1
公开(公告)日：2008-01-10
申请号：US11859644
申请日：2007-09-21
申请人： J. Knight , J. Waldrep , Nadezhda Koshkina
发明人： J. Knight , J. Waldrep , Nadezhda Koshkina
CPC分类号： A61K9/0078 , A61K9/127 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K31/7048 , A61K38/13 , A61K2300/00
摘要： The present invention provides a method of inhibiting growth of lung metastases in an individual comprising the steps of administering a dose of a lipid-drug enhancer liposomal complex and, in sequence, administering a dose of a lipid-anticancer drug liposomal complex. Furthermore, the lipid-drug enhancer liposomal complex may be administered in a continuing dose with the lipid-anticancer drug liposomal complex whereby both liposomal complexes are mixed in the nebulizer. Methods of inhibiting growth of lung metastases in an individual by the sequential administration via aerosolization of a dilauroylphosphatidylcholine-cyclosporin A liposomal complex and a dilauroylphosphatidylcholine-paclitaxel liposomal complex are also provided.
摘要翻译： 本发明提供一种抑制个体肺转移的生长的方法，其包括施用一个剂量的脂质 - 药物增强剂脂质体复合物的步骤，并且依次施用剂量的脂质 - 抗癌药物脂质体复合物。 此外，脂质 - 增强剂脂质体复合物可以与脂质 - 抗癌药物脂质体复合物持续给药，由此两个脂质体复合物都混合在喷雾器中。 还提供了通过二月桂酰磷脂酰胆碱 - 环孢菌素A脂质体复合物和二月桂酰磷脂酰胆碱 - 紫杉醇脂质体复合物的雾化顺序施用来抑制个体肺转移的生长的方法。
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公开(公告)号：US6090407A
公开(公告)日：2000-07-18
申请号：US933254
申请日：1997-09-23
IPC分类号： A61K9/00 , A61K9/12 , A61K9/127 , A61K31/03 , A61K31/175 , A61K31/337 , A61K31/437 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/525 , A61K31/7048 , A61K38/21 , A61K45/00 , A61P35/00
CPC分类号： A61K9/0078 , A61K31/03 , A61K31/175 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/7048 , A61K38/21 , A61K9/127 , Y10S514/938
摘要： The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
摘要翻译： 本发明的小颗粒脂质体或脂质复合物气溶胶化合物和治疗方法涉及掺入脂质体或其它脂质复合物中的脂质或水溶性抗癌药物。 脂质体和复合物在水分散体中从喷雾器到个体的呼吸道施用。 可以使用各种抗癌药，包括20-S-喜树碱，9-硝基喜树碱，9-氨基喜树碱，10,11-亚甲二氧基喜树碱和紫杉醇或其衍生物。 通过吸入给药这些药物比肌肉内给药或口服给药提供更快更有效的抗癌药物吸收。
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公开(公告)号：US20080248096A1
公开(公告)日：2008-10-09
申请号：US12020378
申请日：2008-01-25
IPC分类号： A61K9/127 , A61K31/4375 , A61P35/00
CPC分类号： A61K9/0078 , A61K9/0073 , A61K9/127 , A61K9/19 , A61K31/4745
摘要： Provided herein is a method of treating primary lung cancer or metastatic cancer to the lung in an individual by delivering at least once to the respiratory tract of the individual via inhalation a nebulized liposomal aerosol comprising a dilauroylphosphatidylcholine liposome containing camptothecin or a derivative thereof in an amount sufficient to deliver a pharmacologically effective dose of the camptothecin or its derivative to treat the cancer. Also provided is a nebulized liposomal aerosol comprising the DLPC containing the camptothecin or its derivative and a method of making the liposome-drug comprising the aerosol.
摘要翻译： 本文提供了一种通过吸入至少一次向个体的呼吸道递送一次雾化的脂质体气雾剂，其包含含有喜树碱或其衍生物的二月桂酰磷脂酰胆碱脂质体，其量为一种治疗个体的原发性肺癌或转移性癌症的方法 足以提供药理学有效剂量的喜树碱或其衍生物以治疗癌症。 还提供了包含含有喜树碱或其衍生物的DLPC的雾化脂质体气雾剂和制备包含气溶胶的脂质体药物的方法。
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公开(公告)号：US07348025B2
公开(公告)日：2008-03-25
申请号：US10663573
申请日：2003-09-16
IPC分类号： A61K31/4745 , A61K9/127 , A61L9/04
CPC分类号： A61K9/0078 , A61K9/0073 , A61K9/127 , A61K9/19 , A61K31/4745
摘要： Provided herein is a method of treating primary lung cancer or metastatic cancer to the lung in an individual by delivering at least once to the respiratory tract of the individual via inhalation a nebulized liposomal aerosol comprising a dilauroylphosphatidylcholine liposome containing camptothecin or a derivative thereof in an amount sufficient to deliver a pharmacologically effective dose of the camptothecin or its derivative to treat the cancer. Also provided is a nebulized liposomal aerosol comprising the DLPC containing the camptothecin or its derivative and a method of making the liposome-drug comprising the aerosol.
摘要翻译： 本文提供了一种通过吸入至少一次向个体的呼吸道递送一次雾化的脂质体气雾剂，其包含含有喜树碱或其衍生物的二月桂酰磷脂酰胆碱脂质体，其量为一种治疗个体的原发性肺癌或转移性癌症的方法 足以提供药理学有效剂量的喜树碱或其衍生物以治疗癌症。 还提供了包含含有喜树碱或其衍生物的DLPC的雾化脂质体气雾剂和制备包含气溶胶的脂质体药物的方法。
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公开(公告)号：US07288243B2
公开(公告)日：2007-10-30
申请号：US10439773
申请日：2003-05-16
CPC分类号： A61K9/0078 , A61K9/127 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K31/7048 , A61K38/13 , A61K2300/00
摘要： The present invention provides a method of inhibiting growth of lung metastases in an individual comprising the steps of administering a dose of a lipid-drug enhancer liposomal complex and, in sequence, administering a dose of a lipid-anticancer drug liposomal complex. Furthermore, the lipid-drug enhancer liposomal complex may be administered in a continuing dose with the lipid-anticancer drug liposomal complex whereby both liposomal complexes are mixed in the nebulizer. Methods of inhibiting growth of lung metastases in an individual by the sequential administration via aerosolization of a dilauroylphosphatidylcholine-cyclosporin A liposomal complex and a dilauroylphosphatidylcholine-paclitaxel liposomal complex are also provided.
摘要翻译： 本发明提供一种抑制个体肺转移的生长的方法，其包括施用剂量的脂质 - 药物增强剂脂质体复合物的步骤，并且依次施用剂量的脂质 - 抗癌药物脂质体复合物。 此外，脂质 - 增强剂脂质体复合物可以与脂质 - 抗癌药物脂质体复合物持续给药，由此两个脂质体复合物都混合在喷雾器中。 还提供了通过二月桂酰磷脂酰胆碱 - 环孢菌素A脂质体复合物和二月桂酰磷脂酰胆碱 - 紫杉醇脂质体复合物的雾化顺序施用来抑制个体肺转移的生长的方法。
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公开(公告)号：US20060204447A1
公开(公告)日：2006-09-14
申请号：US10663573
申请日：2003-09-16
IPC分类号： A61K31/4745 , A61L9/04 , A61K9/127
CPC分类号： A61K9/0078 , A61K9/0073 , A61K9/127 , A61K9/19 , A61K31/4745
摘要： Provided herein is a method of treating primary lung cancer or metastatic cancer to the lung in an individual by delivering at least once to the respiratory tract of the individual via inhalation a nebulized liposomal aerosol comprising a dilauroylphosphatidylcholine liposome containing camptothecin or a derivative thereof in an amount sufficient to deliver a pharmacologically effective dose of the camptothecin or its derivative to treat the cancer. Also provided is a nebulized liposomal aerosol comprising the DLPC containing the camptothecin or its derivative and a method of making the liposome-drug comprising the aerosol.
摘要翻译： 本文提供了一种通过吸入至少一次向个体的呼吸道递送一次雾化的脂质体气雾剂，其包含含有喜树碱或其衍生物的二月桂酰磷脂酰胆碱脂质体，其量为一种治疗个体的原发性肺癌或转移性癌症的方法 足以提供药理学有效剂量的喜树碱或其衍生物以治疗癌症。 还提供了包含含有喜树碱或其衍生物的DLPC的雾化脂质体气雾剂和制备包含气溶胶的脂质体药物的方法。
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公开(公告)号：USRE40300E1
公开(公告)日：2008-05-06
申请号：US10927663
申请日：2004-08-26
CPC分类号： A61K9/0078 , A61K9/124 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K48/00 , Y10S977/773 , Y10S977/801 , Y10S977/907 , Y10S977/915 , Y10S977/926
摘要： The present invention provides a method of increasing the deposition of aerosolized drug in the respiratory tract of an individual or animal, comprising the step of administering said aerosolized drug in an air mixture containing up to about 10% carbon dioxide gas.
摘要翻译： 本发明提供一种增加气雾化药物在个体或动物呼吸道中的沉积的方法，其包括将所述气雾化药物施用于含有高达约10％二氧化碳气体的空气混合物中的步骤。
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公开(公告)号：US06440393B1
公开(公告)日：2002-08-27
申请号：US09729468
申请日：2000-12-04
IPC分类号： A61K912
CPC分类号： A61K9/0078 , A61K9/124 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K48/00 , Y10S977/773 , Y10S977/801 , Y10S977/907 , Y10S977/915 , Y10S977/926
摘要： The present invention provides a method of increasing the deposition of aerosolized drug in the respiratory tract of an individual or animal, comprising the step of administering said aerosolized drug in an air mixture containing up to about 10% carbon dioxide gas.
摘要翻译： 本发明提供一种增加气雾化药物在个体或动物呼吸道中的沉积的方法，其包括将所述气雾化药物施用于含有高达约10％二氧化碳气体的空气混合物中的步骤。
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10.发明授权Composition for treating cancer via liposomal aerosol formulation containing taxol 失效通过含有紫杉醇的脂质体气雾剂制剂治疗癌症的组合物公开(公告)号：US06346233B1
公开(公告)日：2002-02-12
申请号：US09617623
申请日：2000-07-17
IPC分类号： A61K912
CPC分类号： A61K9/0078 , A61K9/127 , A61K31/03 , A61K31/175 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/7048 , A61K38/21 , Y10S514/938
摘要： The small particle liposome or lipid complex aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes or other lipid complexes. The liposomes and complexes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro-camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anticancer drug than does intramuscular administration or oral administration.
摘要翻译： 本发明的小颗粒脂质体或脂质复合物气溶胶化合物和治疗方法涉及掺入脂质体或其它脂质复合物中的脂质或水溶性抗癌药物。 脂质体和复合物在水分散体中从喷雾器到个体的呼吸道施用。 可以使用各种抗癌药，包括20-S-喜树碱，9-硝基喜树碱，9-氨基喜树碱，10,11-亚甲二氧基喜树碱和紫杉醇或其衍生物。 通过吸入给药这些药物比肌肉内给药或口服给药提供更快更有效的抗癌药物吸收。
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