公开(公告)号：US20180296597A1

公开(公告)日：2018-10-18

申请号：US15953939

申请日：2018-04-16

Applicant: Parviz Gharagozloo

Inventor： Parviz Gharagozloo

IPC: A61K33/30 ,  A61K31/519 ,  A61K31/221 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K33/04 ,  A61K33/06 ,  A61K31/01 ,  A61K45/06

Abstract: A profertility composition for administration to infertile men with sperm oxidative stress is disclosed. The composition comprises a unique combination of a pharmaceutically acceptable vitamin E, vitamin C, selenium, zinc, folic acid, lycopene and at least one carnitine source.

公开(公告)号：US20100278939A1

公开(公告)日：2010-11-04

申请号：US12771928

申请日：2010-04-30

Applicant: Parviz Gharagozloo

Inventor： Parviz Gharagozloo

IPC: A61K33/30 ,  A61P15/08

CPC classification number: A61K33/30 ,  A61K31/01 ,  A61K31/221 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/519 ,  A61K33/04 ,  A61K33/06 ,  A61K45/06 ,  A61K2300/00

Abstract: A profertility composition for administration to infertile men with sperm oxidative stress is disclosed. The composition comprises a unique combination of a pharmaceutically acceptable vitamin E, vitamin C, selenium, zinc, folic acid, lycopene and at least one carnitine source.

Abstract translation: 公开了一种用于施用精子氧化应激不育男性的孕激素组合物。 该组合物包含药学上可接受的维生素E，维生素C，硒，锌，叶酸，番茄红素和至少一种肉毒碱的独特组合。

公开(公告)号：US06864261B2

公开(公告)日：2005-03-08

申请号：US10429078

申请日：2003-05-02

Applicant: Parviz Gharagozloo ,  Khondaker Islam ,  Donald J. Kyle ,  Qun Sun ,  Laykea Tafesse ,  John William Frank Whitehead ,  Ji Yang ,  Xiaoming Zhou

Inventor： Parviz Gharagozloo ,  Khondaker Islam ,  Donald J. Kyle ,  Qun Sun ,  Laykea Tafesse ,  John William Frank Whitehead ,  Ji Yang ,  Xiaoming Zhou

IPC: A61P25/00 ,  A61P29/00 ,  C07D213/74 ,  C07D213/80 ,  C07D213/85 ,  C07D401/04 ,  C07D401/14 ,  C07D405/12 ,  A61K31/496

CPC classification number: C07D213/74 ,  C07D213/80 ,  C07D213/85 ,  C07D401/04 ,  C07D401/14 ,  C07D405/12

Abstract: A compound of formula (wherein A, R1, R2, R6, m and n are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Piperazine Compound”); pharmaceutical compositions comprising a Piperazine Compound; and methods for treating pain, urinary incontinence (UI), an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia and depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperazine Compound are disclosed.

Abstract translation: 式（其中A，R 1，R 2，R 6，m和n在本文中公开）的化合物或其药学上可接受的盐（“哌嗪化合物”）; 包含哌嗪化合物的药物组合物; 和治疗疼痛，尿失禁（UI），成瘾性障碍，帕金森病，帕金森综合征，焦虑症，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷，限制性脑功能，亨廷顿氏舞蹈症 ，肌萎缩性侧索硬化（ALS），痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍和抑郁症，包括向有需要的动物施用有效量的哌嗪化合物。

公开(公告)号：US20090253727A1

公开(公告)日：2009-10-08

申请号：US12485612

申请日：2009-06-16

Applicant: R. Richard Goehring ,  Zhengming Chen ,  John Whitehead ,  Parviz Gharagozloo ,  Sam Victory ,  Donald Kyle

Inventor： R. Richard Goehring ,  Zhengming Chen ,  John Whitehead ,  Parviz Gharagozloo ,  Sam Victory ,  Donald Kyle

IPC: C07D401/04 ,  A61K31/4545 ,  A61P29/00

CPC classification number: C07D417/04 ,  C07D401/04

Abstract: A compound of the having the general formula (I) or general formula (II): wherein Z, A, B, C, R1, R2, Q, W, and n are as described herein.

Abstract translation: 具有通式（I）或通式（II）的化合物：其中Z，A，B，C，R 1，R 2，Q，W和n如本文所述。

公开(公告)号：US07563809B2

公开(公告)日：2009-07-21

申请号：US11069728

申请日：2005-03-01

Applicant: R. Richard Goehring ,  Zhengming Chen ,  John Whitehead ,  Parviz Gharagozloo ,  Sam Victory ,  Donald Kyle

Inventor： R. Richard Goehring ,  Zhengming Chen ,  John Whitehead ,  Parviz Gharagozloo ,  Sam Victory ,  Donald Kyle

IPC: C07D417/04 ,  C07D417/14 ,  A61K31/5415 ,  A61P29/00

CPC classification number: C07D417/04 ,  C07D401/04

Abstract: The invention relates to benzothiadiazole compounds of formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, A, B, C, W, Z and n are defined as set forth in the specification. The compounds of the invention have affinity for the nociceptin receptor. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to modulation of the nociceptin receptor. Compounds of the present invention are especially useful for treating pain.

Abstract translation: 本发明涉及式（I）的苯并噻二唑化合物及其药学上可接受的盐，前药或溶剂化物，其中R1，R2，A，B，C，W，Z和n如说明书所述定义。 本发明的化合物对伤害感受肽受体具有亲和力。 本发明还涉及式（I）化合物用于治疗响应于伤害感受肽受体调节的病症的用途。 本发明的化合物特别适用于治疗疼痛。

公开(公告)号：US06861421B2

公开(公告)日：2005-03-01

申请号：US10126507

申请日：2002-04-18

Applicant: R. Richard Goehring ,  Zhengming Chen ,  John Whitehead ,  Parviz Gharagozloo ,  Sam Victory ,  Donald Kyle

Inventor： R. Richard Goehring ,  Zhengming Chen ,  John Whitehead ,  Parviz Gharagozloo ,  Sam Victory ,  Donald Kyle

IPC: C07D285/16 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/549 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  C07D401/04 ,  C07D417/04 ,  A61K31/5415 ,  C07D417/14

CPC classification number: C07D417/04 ,  C07D401/04

Abstract: A compound of the having the general formula (I) or general formula (II): wherein Z, A, B, C, R1, R2, Q, W, and n are as described herein.

Abstract translation: 具有通式（I）或通式（II）的化合物：其中Z，A，B，C，R 1，R 2，Q，W和n如本文所述。

公开(公告)号：US20220008460A1

公开(公告)日：2022-01-13

申请号：US17476801

申请日：2021-09-16

Applicant: Parviz Gharagozloo

Inventor： Parviz Gharagozloo

IPC: A61K33/30 ,  A61K31/01 ,  A61K31/221 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K33/04 ,  A61K33/06 ,  A61K45/06 ,  A61K31/519

Abstract: A profertility composition for administration to infertile men with sperm oxidative stress is disclosed. The composition comprises a unique combination of a pharmaceutically acceptable vitamin E, vitamin D, vitamin C, selenium, zinc, folate, lycopene, at least one carnitine source, and optionally Coenzyme Q10. Also disclosed are methods of treating male infertility.

公开(公告)号：US09943543B2

公开(公告)日：2018-04-17

申请号：US13749177

申请日：2013-01-24

Applicant: Parviz Gharagozloo

Inventor： Parviz Gharagozloo

IPC: A61K9/46 ,  A61K33/30 ,  A61K31/01 ,  A61K31/221 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K33/04 ,  A61K33/06 ,  A61K45/06 ,  A61K31/519

CPC classification number: A61K33/30 ,  A61K31/01 ,  A61K31/221 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/519 ,  A61K33/04 ,  A61K33/06 ,  A61K45/06 ,  A61K2300/00

Abstract: A profertility composition for administration to infertile men with sperm oxidative stress is disclosed. The composition comprises a unique combination of a pharmaceutically acceptable vitamin E, vitamin C, selenium, zinc, folic acid, lycopene and at least one carnitine source.

公开(公告)号：US08377454B2

公开(公告)日：2013-02-19

申请号：US12771928

申请日：2010-04-30

Applicant: Parviz Gharagozloo

Inventor： Parviz Gharagozloo

IPC: A61K9/00

CPC classification number: A61K33/30 ,  A61K31/01 ,  A61K31/221 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K31/519 ,  A61K33/04 ,  A61K33/06 ,  A61K45/06 ,  A61K2300/00

Abstract: A profertility composition for administration to infertile men with sperm oxidative stress is disclosed. The composition comprises a unique combination of a pharmaceutically acceptable vitamin E, vitamin C, selenium, zinc, folic acid, lycopene and at least one carnitine source.

Abstract translation: 公开了一种用于施用精子氧化应激不育男性的孕激素组合物。 该组合物包含药学上可接受的维生素E，维生素C，硒，锌，叶酸，番茄红素和至少一种肉毒碱的独特组合。

公开(公告)号：US07169782B2

公开(公告)日：2007-01-30

申请号：US10195530

申请日：2002-07-16

Applicant: Qun Sun ,  Donald J. Kyle ,  Parviz Gharagozloo ,  Ji Yang

Inventor： Qun Sun ,  Donald J. Kyle ,  Parviz Gharagozloo ,  Ji Yang

IPC: C07D277/14 ,  C07D417/06 ,  A61K31/426 ,  A61K31/4439

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/14 ,  C07D279/06 ,  C07D417/04 ,  C07D417/06

Abstract: This invention relates aryl substituted thiazolidinones of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein R1 and R2, are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

Abstract translation: 本发明涉及式I的芳基取代的噻唑烷酮：或其药学上可接受的盐或溶剂合物，其中R 1和R 2 2在本说明书中定义。 本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途 作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。