公开(公告)号：US20240335381A1

公开(公告)日：2024-10-10

申请号：US18629522

申请日：2024-04-08

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu ,  James R Huey

IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K31/57 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/36 ,  A61K47/44 ,  A61P5/24

CPC分类号： A61K9/1075 ,  A61K9/0014 ,  A61K31/57 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/36 ,  A61K47/44 ,  A61P5/24

摘要： Thickened microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. In relation to conventional oil-in-water (OIW) microemulsions, the described thickened microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the thickened MOIW microemulsion are modified with alcohol and an alcohol-lipid phase thickener and can solubilize alcohol-soluble species, including nonderivatized hormones. Preferably, the modified oil phase droplets of the thickened MOIW microemulsion directly solubilize nonderivatized hormones. The polar continuous “water” phase of the thickened MOIW microemulsion is modified with a continuous phase thickener. The modified oil phase droplets disperse into the modified polar continuous phase of the thickened MOIW microemulsion.

公开(公告)号：US20230398164A1

公开(公告)日：2023-12-14

申请号：US18209168

申请日：2023-06-13

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu

IPC分类号： A61K36/288 ,  A61K47/44 ,  A61K31/404 ,  A61K31/381 ,  A61K47/14 ,  A61K9/107 ,  A61K36/515 ,  A61K36/328 ,  A61K31/355 ,  A61K9/00 ,  B82Y5/00

CPC分类号： A61K36/288 ,  A61K47/44 ,  A61K31/404 ,  A61K31/381 ,  A61K47/14 ,  A61K9/1075 ,  A61K36/515 ,  A61K36/328 ,  A61K31/355 ,  A61K9/0053 ,  B82Y5/00

摘要： An intra-oral, nanoemulsion assists in balancing the histamine response in subjects when orally administered. The intra-oral, nanoemulsion includes at least one monolayer surfactant bound particle and a continuous phase. The monolayer surfactant bound particles are carried by the continuous phase. A method of making and of administering the nanoemulsion to balance the histamine response in subjects also is described. The nanoemulsion is ingestible and edible.

公开(公告)号：US20230114405A1

公开(公告)日：2023-04-13

申请号：US17967267

申请日：2022-10-17

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu

IPC分类号： A61K31/568 ,  A61K47/14 ,  A61K47/44 ,  A61K9/00 ,  A61K9/107 ,  A61K9/48 ,  A61P5/26

摘要： Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. The described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize alcohol-soluble species, including nonderivatized hormones. The polar continuous “water” phase of the MOIW microemulsion is modified with a sugar or sugar alcohol.

公开(公告)号：US20220233441A1

公开(公告)日：2022-07-28

申请号：US17672988

申请日：2022-02-16

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu

IPC分类号： A61K9/107 ,  A61K31/05 ,  A61K31/352 ,  A61K9/00 ,  A61K45/06 ,  A61K47/10 ,  A61K47/44

摘要： Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. The described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize oil-soluble species, including cannabis extracts and terpenes. The polar continuous “water” phase of the MOIW microemulsion is modified with a sugar or sugar alcohol.

公开(公告)号：US20220265748A1

公开(公告)日：2022-08-25

申请号：US17584661

申请日：2022-01-26

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu

IPC分类号： A61K36/288 ,  A61K9/107 ,  A61K36/328 ,  A61K47/44 ,  A61K31/355 ,  A61K36/515 ,  A61K9/00 ,  A61K31/381 ,  A61K31/404 ,  A61K47/14

摘要： An intra-oral, nanoemulsion blend is provided that enhances liver and toxin excretion performance in mammals when orally administered. A solid powder toxin binding composition also is provided that may be used to irreversibly bind the toxins reaching the bowel so that once the toxins are excreted into the bowel, they may not be reabsorbed, and are thus eliminated. A method of administering the nanoemulsion blend and the toxin binding composition to enhance toxin excretion also is described. The nanoemulsion blend is ingestible and edible.

公开(公告)号：US20240350519A1

公开(公告)日：2024-10-24

申请号：US18615236

申请日：2024-03-25

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu ,  James R Huey ,  David Durkee ,  Michelle Schwenk

IPC分类号： A61K31/00 ,  A23G3/34 ,  A23G3/36 ,  A23G3/40 ,  A23G3/42 ,  A23G3/44 ,  A23G3/48 ,  A61K9/00 ,  A61K9/107 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/07 ,  A61K31/122 ,  A61K31/197 ,  A61K31/198 ,  A61K31/205 ,  A61K31/355 ,  A61K31/375 ,  A61K31/593 ,  A61K33/30 ,  A61K36/185 ,  A61K36/539 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/42 ,  A61K47/44

CPC分类号： A61K31/658 ,  A23G3/0019 ,  A23G3/368 ,  A23G3/40 ,  A23G3/42 ,  A23G3/44 ,  A23G3/48 ,  A61K9/0056 ,  A61K9/1075 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/07 ,  A61K31/122 ,  A61K31/197 ,  A61K31/198 ,  A61K31/205 ,  A61K31/355 ,  A61K31/375 ,  A61K31/593 ,  A61K33/30 ,  A61K36/185 ,  A61K36/539 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/42 ,  A61K47/44

摘要： Microemulsions incorporated into gummy confections are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. In relation to conventional oil-in-water (OIW) microemulsions, prior to incorporation into the gummy confections the described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can better deliver oil-soluble species to the bloodstream than can oil blends or the oil phases of conventional oil-in-water (OIW) microemulsions. The polar continuous “water” phase of the MOIW microemulsion is modified with a sugar or sugar alcohol. The modified oil phase droplets disperse into the modified polar continuous phase of the MOIW microemulsion prior to incorporation into the gummy confection.

公开(公告)号：US20230127581A1

公开(公告)日：2023-04-27

申请号：US17972754

申请日：2022-10-25

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu

IPC分类号： A61K31/5685 ,  A61K9/107 ,  A61K31/355 ,  A61K47/14 ,  A61K47/24 ,  A61K36/752 ,  A61K47/26

摘要： Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. In relation to conventional oil-in-water (OIW) microemulsions, the described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize alcohol-soluble species, including nonderivatized hormones. More preferably, the modified oil phase droplets of the MOIW microemulsion directly solubilize nonderivatized hormones. The oil phase droplets of the MOIW microemulsion include DHEA, pregnenolone, and a polyphenol, where a ratio of DHEA to polyphenol is from 1:1 to 12:1 by weight. Methods of supporting and/or increasing bloodstream hormone levels in perimenopausal and postmenopausal females and improving menopausal symptoms also are disclosed.

公开(公告)号：US20220273570A1

公开(公告)日：2022-09-01

申请号：US17707067

申请日：2022-03-29

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu ,  George Gordon Cantlay, IV

IPC分类号： A61K9/127 ,  A61K47/24 ,  A61K47/10 ,  A61K47/44 ,  A61K47/14 ,  A61K31/12 ,  A61K36/324 ,  A61K31/352 ,  A61K31/4375 ,  A61K31/366 ,  A61K36/19 ,  A61K31/05 ,  A61K31/404 ,  A61K31/015 ,  A61K36/185 ,  A61K33/30 ,  A61K33/06 ,  A61K9/00

摘要： Compositions in the form of oil-based solutions that form oil-in-water (OIW) microemulsions in the aqueous environment of the GI tract when taken orally via a hard or soft capsule are described. The resulting microemulsions that form from the oil-based solution within the GI tract can rapidly deliver oil-soluble species and alcohol-soluble species (including PEG derivative assisted alcohol-soluble species) deliverables to the bloodstream through the tissues forming the GI tract. The in situ formed microemulsions resulting from consumption of the encapsulated oil-based solutions include oil-phase microemulsion droplets of monolayer surfactant bound particles suspended in the aqueous continuous phase of the GI tract. The oil-based solutions also may in situ form water-core liposomes suspended in the aqueous continuous phase of the GI tract.

公开(公告)号：US11344497B1

公开(公告)日：2022-05-31

申请号：US16214289

申请日：2018-12-10

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu

IPC分类号： A61K9/107 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K31/05 ,  A61K31/122 ,  A61K47/24 ,  B82Y5/00 ,  A61K9/00 ,  A61K9/127

摘要： An aqueous, intra-oral, nanoemulsion blend is provided that enhances mitochondrial performance in mammals when orally administered. The blend includes at least two different monolayer surfactant bound particle components and at least one bilayer water-core liposome component. The blend optionally may include a micelle.

公开(公告)号：US11304900B1

公开(公告)日：2022-04-19

申请号：US16902842

申请日：2020-06-16

申请人： Quicksilver Scientific, Inc.

发明人： Christopher W. Shade ,  Steven Tieu

IPC分类号： A61K9/00 ,  A61K9/51 ,  A61K9/107 ,  A61K9/127 ,  A61K47/44 ,  A61K8/67 ,  A61K31/375 ,  A61K31/51 ,  A61K31/355 ,  A61K31/122 ,  A61K31/07 ,  A61K31/593 ,  A61K31/525 ,  A61K31/455 ,  A61K31/4415 ,  A61K31/714

摘要： An aqueous, intra-oral, transparent nanoemulsion blend in the form of a stable dispersion delivers both oil- and water-soluble components of a vitamin supplement in the desired concentrations to the cells of a mammal when orally administered. The transparent nanoemulsion blend includes at least two different bilayer water-core liposome components and at least one monolayer surfactant bound particle component. The transparent nanoemulsion blend optionally may include a micelle formed from phosphatidylcholine (PC).