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公开(公告)号:US20220028416A1
公开(公告)日:2022-01-27
申请号:US17297695
申请日:2019-11-28
Applicant: RAMBAM MED-TECH LTD. , BAR-ILAN UNIVERSITY
Inventor: Jacob COHEN , Joseph KESHET , Alma COHEN
Abstract: A system comprising at least one hardware processor and a non-transitory computer-readable storage medium having stored thereon program instructions, the program instructions executable by the at least one hardware processor to: receive a voice recording comprising a phonation by a subject, analyze said voice recording to calculate a fundamental frequency contour curve of said phonation, measure at least one of (i) a time period from a start of said phonation until said contour curve reaches a settled level, (ii) a slope of said contour curve during said time period, and (iii) an area under said contour curve during said time period, and determine a glottal closure insufficiency in said subject based, at least in part, on said measuring.
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公开(公告)号:US20210052777A1
公开(公告)日:2021-02-25
申请号:US16967237
申请日:2019-02-04
Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED , B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY , RAMBAM MED-TECH LTD.
Inventor: Shulamit LEVENBERG , Eddy KARNIELI , Eli Chaim LEWIS , Margarita BECKERMAN , Chava HAREL
Abstract: The present invention is directed to, inter alia, a scaffold-cell construct including a biocompatible polymer (e.g., poly-l-lactic acid (PLLA) and polylactic glycolic acid (PLGA)) and recombinant cells having increased GLUT4 levels and/or activity. The invention is further directed to methods for reducing glucose levels in a subject in need thereof. Also provided are methods of producing the scaffold-cell construct of the invention.
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公开(公告)号:US10561707B2
公开(公告)日:2020-02-18
申请号:US15413991
申请日:2017-01-24
Inventor: Shira Toledano , Ofra Kessler , Gera Neufeld , Yoreh Barak , Yelena Mumblat
Abstract: The present invention relates, according to some embodiments, method of treating eye diseases, such as AMD by administering Semaphorin 3C (Sema3C) or a variant thereof having amino acid modifications at furin-like pro-protein convertase cleavage sites, rendering these sites resistant to cleavage.
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公开(公告)号:US20190309368A1
公开(公告)日:2019-10-10
申请号:US16449585
申请日:2019-06-24
Applicant: Walter Gabriel WASSER , Technion Research & Development Foundation Limited , Ramot at Tel-Aviv University Ltd. , Rambam Med-Tech Ltd.
Inventor: Karl SKORECKI , Shay TZUR , Saharon ROSSET , Walter Gabriel WASSER , Doron M. BEHAR , Revital SHEMER
IPC: C12Q1/6883 , C12Q1/70 , G01N33/68
Abstract: Provided are methods and kits for determining predisposition of a subject to develop a kidney disease, by identifying in a sample of the subject at least one APOL1 polypeptide variant which is characterized by a higher trypanolytic activity on Trypanosoma brucei rhodesiense as compared to the trypanolytic activity of wild type APOL1 polypeptide as set forth in SEQ ID NO:1 on the Trypanosoma brucei rhodesiense under identical assay conditions; or at least one APOL1 nucleotide mutation in the APLO1 genomic sequence set forth in SEQ ID NO:3, wherein the at least one nucleotide mutation or polypeptide variant being in linkage disequlibrium (LD) with the S342G mutation in the APOL1 polypeptide set forth in SEQ ID NO:1, wherein presence of the APOL1 polypeptide variant indicates increased predisposition of the subject to develop the kidney disease.
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公开(公告)号:US20170354453A1
公开(公告)日:2017-12-14
申请号:US15527499
申请日:2015-11-19
Inventor: Yakov Krasik , Joshua Felsteiner , Yakov Slutsker , Ziv Gil , Jacob Cohen , Yoav Binen-Baum
CPC classification number: A61B18/042 , A61B1/018 , A61B2017/00039 , A61B2017/00057 , A61B2017/00061 , A61B2018/00791 , A61B2018/00982 , H05H1/2406 , H05H2001/245 , H05H2001/2456 , H05H2001/2462 , H05H2245/122
Abstract: A system for generating cold plasma is presented, suitable for use in in-vivo treatment of biological tissue. The system comprising: a control unit connectable to an elongated member at a first proximal end of the elongated member. The elongated member comprises a plasma generating unit at a second distal end thereof and gas and electricity transmission channels extending from said first proximal end towards said plasma generating unit. The control unit comprises a gas supply unit configured to provide predetermined flow rate of selected gas composition through said gas transmission channel and a power supply unit configured to generate selected sequence of high-frequency electrical pulses, typically in mega Hertz range, directed through said electricity transmission channel, thereby providing power and gas of said selected composition to the plasma generating unit for generating cold plasma.
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公开(公告)号:US20170312388A1
公开(公告)日:2017-11-02
申请号:US15516805
申请日:2015-10-07
Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. , Rambam Med-Tech Ltd.
Inventor: Oded SHOSEYOV , Danny PORATH , Ofra BENNY , Yaron BAR-LAVIE , Amos OFER
Abstract: The invention disclosed herein generally provides implantable medical devices and implants that may be removed on-demand from a subject's body at any time after their implanting in the body, without necessitating invasive procedures.
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公开(公告)号:US20250041275A1
公开(公告)日:2025-02-06
申请号:US18911431
申请日:2024-10-10
Inventor: Iyad KHAMAYSI , Salim HADAD , Zaid ABASSI
IPC: A61K31/405 , A61K31/194 , A61K31/196 , A61K47/54 , A61P13/12
Abstract: The invention relates generally to the field of compositions including one or more conjugates of di-sugar and a nonsteroidal anti-inflammatory drug (NSAID), and use of same in methods for treating a disease or a disorder in a subject in need thereof.
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公开(公告)号:US20240078665A1
公开(公告)日:2024-03-07
申请号:US18241502
申请日:2023-09-01
Applicant: RAMBAM MED-TECH LTD.
Inventor: Myroslav Lutsyk
CPC classification number: G06T7/0012 , G16H50/20 , G06T2207/10072 , G06T2207/20081 , G06T2207/30096
Abstract: A system and method of predicting propensity of metastasis of a tumor in a patient by at least one processor may include: receiving, from a first scan modality, a first scan comprising a set of scan images depicting metabolic information; receiving, from a second scan modality, a second scan comprising a set of scan images depicting anatomical information; segmenting the first scan to identify a volumetric segment representing a suspected tumor, based on the depicted metabolic information; extracting one or more radiomics features from the second scan, corresponding to the volumetric segment, based on the depicted anatomical information; and predicting propensity of metastasis of the suspected tumor, based on the one or more radiomics features.
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公开(公告)号:US20230282332A1
公开(公告)日:2023-09-07
申请号:US18008169
申请日:2021-06-06
Applicant: RAMBAM MED-TECH LTD.
Inventor: Goded SHAHAF
CPC classification number: G16H20/70 , A61B5/369 , A61B5/1103 , G16H50/30
Abstract: System and methods are adapted to extract client attention/engagement/effort barrier electrophysiological signal during practice, to combine the attention/engagement/effort barrier with level of success of the client in performing practice task, in order to provide practice recommendation during the current session or following it.
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公开(公告)号:US20230201201A1
公开(公告)日:2023-06-29
申请号:US17923508
申请日:2021-05-06
Inventor: Karl SKORECKI , Ira BAVLI-KERTSELLI , Tali SHEMER , Etty KRUZEL , Orly TABACHNIKOV
IPC: A61K31/517 , A61K31/454
CPC classification number: A61K31/517 , A61K31/454
Abstract: The invention in some embodiments thereof, relates to the field of compositions and/or pharmaceutical compositions comprising one or more biologically active compound, and is directed to methods of using same such as for treating an ApoL1 related disease or a disorder in a subject.
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