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公开(公告)号：US07820400B2
公开(公告)日：2010-10-26
申请号：US11453186
申请日：2006-06-13
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , C07K16/28 , C07K16/3015 , C07K2317/21 , C07K2317/77 , C12N5/163 , C12N5/166 , C12N2510/02 , C12N2510/04 , G01N33/57492
摘要： The present invention provides monoclonal antibody-producing hybridomas designated 27.F7 and 27.B1. The invention provides a method of detecting TIP-2 antigen bearing cancer cells in a sample. The invention provides a method of detecting TIP-2 antigen on the surface of cancer cells. The invention provides a method for diagnosing cancer in a subject. The invention provides a method for delivering exogenous material to TIP-2 antigen-bearing cancer cells of a human subject. The invention provides a method for treating cancer in a human subject. The invention provides isolated peptides having the amino acid sequences Lys Leu Leu Gly Gly Gln Ile Gly Leu (SEQ. ID No.) and Ser Leu Leu Gly Cys Arg His Tyr Glu Val (SEQ. ID No.). The invention provides a method for immunohistochemical screening of a tissue section for the presence of TIP-2 antigen bearing cancer cells. The invention provides a kit for detecting the presence of TIP-2 antigen-bearing cancer cells. The invention provides a method for detecting the presence of TIP-2 antigen. The invention provides a method for immunohistochemical screening of tissue sections. The invention provides a method for monitoring progression of cancer wherein the cancer cells are TIP-2 antigen-bearing cells. The invention provides a method for diagnosing cancer associated with the expression of TIP-2.
摘要翻译： 本发明提供了称为27.F7和27.B1的产生单克隆抗体的杂交瘤。 本发明提供一种检测样品中携带TIP-2抗原的癌细胞的方法。 本发明提供了检测癌细胞表面的TIP-2抗原的方法。 本发明提供了一种用于诊断受试者的癌症的方法。 本发明提供了将外源性材料递送至人受试者的TIP-2抗原携带癌细胞的方法。 本发明提供了一种治疗人类受试者的癌症的方法。 本发明提供具有氨基酸序列Lys Leu Leu Gly Gly Gln Ile Gly Leu（SEQ ID NO）和Ser Leu Leu Gly Cys Arg His Tyr Glu Val的分离肽（SEQ ID NO：SEQ ID NO： 本发明提供了一种组织切片对于携带TIP-2抗原的癌细胞存在的免疫组织化学筛选方法。 本发明提供了用于检测携带TIP-2抗原的癌细胞的存在的试剂盒。 本发明提供了检测TIP-2抗原存在的方法。 本发明提供了组织切片的免疫组织化学筛选方法。 本发明提供了一种监测癌症进展的方法，其中癌细胞是携带TIP-2抗原的细胞。 本发明提供了一种诊断与TIP-2表达相关的癌症的方法。
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公开(公告)号：US20060292644A1
公开(公告)日：2006-12-28
申请号：US11453186
申请日：2006-06-13
IPC分类号： G01N33/574 , C12N5/06 , C07K16/30
CPC分类号： G01N33/57407 , C07K16/28 , C07K16/3015 , C07K2317/21 , C07K2317/77 , C12N5/163 , C12N5/166 , C12N2510/02 , C12N2510/04 , G01N33/57492
摘要： The present invention provides monoclonal antibody-producing hybridomas designated 27.F7 and 27.B1. The invention provides a method of detecting TIP-2 antigen bearing cancer cells in a sample. The invention provides a method of detecting TIP-2 antigen on the surface of cancer cells. The invention provides a method for diagnosing cancer in a subject. The invention provides a method for delivering exogenous material to TIP-2 antigen-bearing cancer cells of a human subject. The invention provides a method for treating cancer in a human subject. The invention provides isolated peptides having the amino acid sequences Lys Leu Leu Gly Gly Gln Ile Gly Leu (SEQ. ID No.) and Ser Leu Leu Gly Cys Arg His Tyr Glu Val (SEQ. ID No.). The invention provides a method for immunohistochemical screening of a tissue section for the presence of TIP-2 antigen bearing cancer cells. The invention provides a kit for detecting the presence of TIP-2 antigen-bearing cancer cells. The invention provides a method for detecting the presence of TIP-2 antigen. The invention provides a method for immunohistochemical screening of tissue sections. The invention provides a method for monitoring progression of cancer wherein the cancer cells are TIP-2 antigen-bearing cells. The invention provides a method for diagnosing cancer associated with the expression of TIP-2.
摘要翻译： 本发明提供了称为27.F7和27.B1的产生单克隆抗体的杂交瘤。 本发明提供一种检测样品中携带TIP-2抗原的癌细胞的方法。 本发明提供了检测癌细胞表面的TIP-2抗原的方法。 本发明提供了一种用于诊断受试者的癌症的方法。 本发明提供了将外源性材料递送至人受试者的TIP-2抗原携带癌细胞的方法。 本发明提供了一种治疗人类受试者的癌症的方法。 本发明提供具有氨基酸序列Lys Leu Leu Gly Gly Gln Ile Gly Leu（SEQ ID NO）和Ser Leu Leu Gly Cys Arg His Tyr Glu Val的分离肽（SEQ ID NO：SEQ ID NO： 本发明提供了一种组织切片对于携带TIP-2抗原的癌细胞存在的免疫组织化学筛选方法。 本发明提供了用于检测携带TIP-2抗原的癌细胞的存在的试剂盒。 本发明提供了检测TIP-2抗原存在的方法。 本发明提供了组织切片的免疫组织化学筛选方法。 本发明提供了一种监测癌症进展的方法，其中癌细胞是携带TIP-2抗原的细胞。 本发明提供了一种诊断与TIP-2表达相关的癌症的方法。
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公开(公告)号：US07060802B1
公开(公告)日：2006-06-13
申请号：US09664958
申请日：2000-09-18
IPC分类号： C07K16/00
CPC分类号： G01N33/57407 , C07K16/28 , C07K16/3015 , C07K2317/21 , C07K2317/77 , C12N5/163 , C12N5/166 , C12N2510/02 , C12N2510/04 , G01N33/57492
摘要： This invention provides monoclonal antibody-producing hybridomas designated 27.F7 and 27.B1. The invention also provides methods for detecting TIP-2 antigen-bearing cancer cells in a sample, detecting the presence of TIP-2 antigen, optionally on the surface of cancer cells, immunohistochemical screening of a tissue section for the presence of TIP-2 antigen bearing cancer cells, diagnosing cancer in a subject, monitoring progression of cancer wherein the cancer cells are TIP-2 antigen-bearing cells, delivering exogenous material to TIP-2 antigen-bearing cancer cells of a human subject, and treating cancer in a human subject. This invention further provides a kit for detecting the presence of TIP-2 antigen-bearing cancer cells. This invention also provides isolated peptides having the amino acid sequences Lys Leu Leu Gly Gly Gln Ile Gly Leu (SEQ ID No:3) and Ser Leu Leu Gly Cys Arg His Tyr Glu Val (SEQ ID NO:4).
摘要翻译： 本发明提供了称为27.F7和27.B1的产生单克隆抗体的杂交瘤。 本发明还提供了用于检测样品中TIP-2抗原的癌细胞的方法，任选地在癌细胞表面检测TIP-2抗原的存在，组织切片的TIP-2抗原的存在的免疫组织化学筛选 诊断受试者中的癌症，监测癌症的进展，其中癌细胞是TIP-2抗原携带细胞，将外源性物质递送到人受试者的TIP-2抗原携带癌细胞，以及治疗人类的癌症 学科。 本发明还提供了用于检测携带TIP-2抗原的癌细胞的存在的试剂盒。 本发明还提供了具有氨基酸序列Lys Leu Leu Gly Gly Gln Ile Gly Leu（SEQ ID No.3）和Ser Leu Leu Gly Cys Arg His Tyr Glu Val（SEQ ID NO：4）的分离肽。
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公开(公告)号：US4233353A
公开(公告)日：1980-11-11
申请号：US39575
申请日：1979-05-16
CPC分类号： C04B26/12 , E04D11/02 , E04D5/02 , Y10T428/24355 , Y10T428/24372 , Y10T428/2438 , Y10T442/67
摘要： High-strength built-up roofing (BUR) membranes and systems are provided herein. These BUR products are made using improved glass fiber mat structures having unusual tear resistance in place of organic felts.The glass fiber mats are constructed from two fibrous components, namely, individual filaments, which provide the uniform denseness required for impregnation of saturant asphalt in the interstices of the mat, and extended fiber elements formed by longitudinal extension and connection of fibers from bundles of glass fibers in a wet-laid process, which furnish tear resistance and tensile strength to the BUR membranes and systems.The BUR membranes and systems of this invention have exceedingly high strengths compared with commercially available products of similar construction, and, advantageously, they can be manufactured by a very economical process.
摘要翻译： 本文提供了高强度建筑屋顶（BUR）膜和系统。 这些BUR产品是使用改进的玻璃纤维垫结构制成的，具有不同寻常的抗撕裂性，代替有机毛毡。 玻璃纤维垫由两个纤维组分构成，即单根长丝，其提供在垫子空隙中浸渍饱和沥青所需的均匀致密度，以及由玻璃束纵向延伸和连接纤维形成的延伸纤维元件 纤维在湿法成网过程中，为BUR膜和系统提供抗撕裂性和拉伸强度。 与相似结构的市售产品相比，本发明的BUR膜和系统具有极高的强度，并且有利地，它们可以通过非常经济的方法制造。
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5.发明授权Economical method of making high-strength glass fiber mats particularly useful for roofing products 失效制造高强度玻璃纤维毡的经济方法特别适用于屋顶产品
公开(公告)号：US4200487A
公开(公告)日：1980-04-29
申请号：US39578
申请日：1979-05-16
摘要： The glass mat made herein is comprised of two fibrous components, namely, individual filament glass fibers and extended glass fiber elements. These components are formed herein in situ in a wet-laid process from original bundles of glass fibers. The individual filaments appear by conventional filamentation of the bundles. The extended fiber elements, however, are formed by longitudinal extension of a given bundle whose fibers are connected longitudinally. Thereby the effective length of a fiber element is very much greater than the length of the fibers therein. The fiber elements are further characterized by a non-uniform diameter, as contrasted to the fibers themselves, being thicker in the midsection of the element where connection of fibers is maximized, and tapered towards its ends, where fiber connection is at a minimum.The extended fiber elements preferably predominate by weight of the fibrous content of the mat over the individual filaments. The desired ratio of the two components is achieved in the method of the invention by using bundles whose fibers have a long length, and by very gentle agitation of the dispersion slurry for a short period of time.
摘要翻译： 本文制成的玻璃垫由两种纤维组分组成，即单独的长丝玻璃纤维和延伸的玻璃纤维元件。 这些组分是在原始的玻璃纤维束的湿法成网工艺中原位形成的。 单个细丝通过束的常规纤维出现。 然而，延伸的纤维元件通过其纤维纵向连接的给定束的纵向延伸形成。 因此，纤维元件的有效长度远大于其中纤维的长度。 纤维元件的特征还在于与纤维本身相反的不均匀的直径在纤维连接处最大化的元件的中部较厚，并且在纤维连接处于最小值的端部处逐渐变细。 延伸的纤维元素优选占单丝重量的纤维含量。 在本发明的方法中，通过使用其纤维长度长的纤维束，并且通过非常温和地搅拌分散浆料在短时间内实现两种组分的所需比例。
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公开(公告)号：US4567079A
公开(公告)日：1986-01-28
申请号：US656213
申请日：1984-10-01
CPC分类号： E04D5/12 , Y10T428/24273 , Y10T428/24322 , Y10T428/24372 , Y10T428/24777 , Y10T428/31815
摘要： Lighter weight, high strength, built-up roofing (BUR) membranes, systems and process for obtaining same are provided herein. These BUR membranes are made by using an improved ply sheet having uniform ventability and attachment in the overall assembly and superior resistance to wind uplift. The improved structure involves a ply sheet carrying 1/8 inch diameter or larger perforations along its longitudinal border in an area comprising between 1/5 and about 1/2 the width of the ply sheet. The ply sheets here employed for the BUR assembly or membrane have a thickness essentially not in excess of the layer of bonding agent applied over each ply in the assembly.
摘要翻译： 本文提供了较轻的重量，高强度，建筑屋顶（BUR）膜，用于获得其的系统和方法。 这些BUR膜通过使用具有均匀的通气性和附着在整个组件中的改进的层片制成，并且具有优异的抗风抬升性。 改进的结构包括在包括片层的宽度的1/5和大约1/2之间的区域中沿其纵向边界承载1/8英寸直径或更大穿孔的层片。 这里用于BUR组件或膜的层压板具有基本上不超过在组件中的每个帘布层上施加的粘结剂层的厚度。
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公开(公告)号：US4242404A
公开(公告)日：1980-12-30
申请号：US39577
申请日：1979-05-16
CPC分类号： E04D5/02 , D21H13/40 , Y10T442/691
摘要： What is provided herein is a glass fiber mat having a novel structure and high-strength properties which is particularly useful for roofing products, including built up roofing membranes and systems.The glass mat of the invention is comprised of two fibrous components, namely, individual filament glass fibers and extended glass fiber elements, which are formed in situ in a wet-laid process from original bundles of glass fibers. The individual filaments appear by conventional filamentation of the bundles. The extended fiber elements, however, are formed by longitudinal extension of a given bundle whose fibers are connected longitudinally. Thereby the effective length of a fiber element is very much greater than the length of the fibers therein. The fiber elements are further characterized by a non-uniform diameter, as contrasted to the fibers themselves, being thicker in the mid-section of the element where connection of fibers is maximized, and tapered towards its ends, where fiber connection is at a minimum.The extended fiber elements preferably predominate by weight of the fibrous content of the mat over the individual filaments. The desired ratio of the two components is achieved by using bundles whose fibers have a long length, and by very gentle agitation of the dispersion slurry for a short period of time.
摘要翻译： 本文提供的是具有新颖结构和高强度性质的玻璃纤维垫，其特别适用于屋顶产品，包括建筑屋顶膜和系统。 本发明的玻璃毡由两个纤维组分组成，即单独的细丝玻璃纤维和延伸的玻璃纤维元件，其在原始的玻璃纤维束的湿法成网工艺中原位形成。 单个细丝通过束的常规纤维出现。 然而，延伸的纤维元件通过其纤维纵向连接的给定束的纵向延伸形成。 因此，纤维元件的有效长度远大于其中纤维的长度。 纤维元件的特征还在于与纤维本身相反的不均匀的直径在元件的中间部分较厚，其中纤维的连接最大化，并且朝向其端部逐渐变细，其中光纤连接最小 。 延伸的纤维元素优选占单丝重量的纤维含量。 通过使用其纤维长度长的纤维束，并且通过非常温和地搅拌分散浆料短时间来实现两种组分的期望比例。
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公开(公告)号：US07928023B2
公开(公告)日：2011-04-19
申请号：US11173427
申请日：2005-07-01
IPC分类号： D04H3/00
CPC分类号： D21H13/40 , D21H17/14 , Y10T428/249946 , Y10T428/2964 , Y10T442/20 , Y10T442/2213 , Y10T442/2402 , Y10T442/2992 , Y10T442/60 , Y10T442/604 , Y10T442/644 , Y10T442/699
摘要： A composite sheet material, useful as a component of roofing shingles, and a process of making same, which includes a glass fiber web bound with a thermosetting resin which includes a fatty acid amide having the structural formula RCOONH2, where R is a C8-C25 alkyl.
摘要翻译： 可用作屋顶瓦的组件的复合片材及其制造方法，其包括与热固性树脂结合的玻璃纤维网，其包含具有结构式RCOONH 2的脂肪酸酰胺，其中R是C8-C25 烷基。
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公开(公告)号：US07172678B2
公开(公告)日：2007-02-06
申请号：US10463921
申请日：2003-06-17
CPC分类号： D21H13/40 , D21H17/14 , Y10T428/249946 , Y10T428/2964 , Y10T442/20 , Y10T442/2213 , Y10T442/2402 , Y10T442/2992 , Y10T442/60 , Y10T442/604 , Y10T442/644 , Y10T442/699
摘要： A composite sheet material, useful as a component of roofing shingles, and a process of making same, which includes a glass fiber web bound with a thermosetting resin which includes a fatty acid amide having the structural formula RCOONH2, where R is a C8–C25 alkyl.
摘要翻译： 可用作屋顶瓦的组件的复合片材及其制造方法，其包括与热固性树脂结合的玻璃纤维网，该玻璃纤维网包括具有结构式RCOONH 2的脂肪酸酰胺， 其中R是C 8 -C 20烷基。
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公开(公告)号：US4430158A
公开(公告)日：1984-02-07
申请号：US301663
申请日：1981-09-14
CPC分类号： D21H13/40
摘要： What is described herein is a method of improving the wet tensile strength of sized glass fiber mats characterized by forming the mat from a plurality of glass fibers and a binder composition therefor which consists essentially of a urea-formaldehyde resin and about 0.01 to 5% by weight of a surfactant which is both highly water soluble and which wets the surfaces of sized glass fibers. The preferred surfactant is an anionic surfactant such as a sodium dodecylbenzene sulfonate. The glass mats thus made retained up to 79% of their tensile strength upon being subjected to severe wet conditions.
摘要翻译： 本文所描述的是改进尺寸的玻璃纤维毡的湿拉伸强度的方法，其特征在于由多个玻璃纤维形成垫子及其粘合剂组合物，其基本上由脲 - 甲醛树脂组成，约0.01至5％ 表面活性剂的重量是高水溶性的并且润湿尺寸的玻璃纤维的表面。 优选的表面活性剂是阴离子表面活性剂，例如十二烷基苯磺酸钠。 这样制成的玻璃毡在经受严酷的湿润条件后，其抗拉强度可达79％。
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