公开(公告)号：US07270821B2

公开(公告)日：2007-09-18

申请号：US10240917

申请日：2001-04-09

Applicant: Annick Gehin ,  Robert Gilbert ,  David Stuart ,  David Rowlands

Inventor： Annick Gehin ,  Robert Gilbert ,  David Stuart ,  David Rowlands

IPC: A61K39/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/735 ,  C07K2319/80 ,  C12N15/62 ,  C12N2730/10122 ,  Y02A50/466

Abstract: The hepatitis B virus (HBV) capsid is made up of a single species of protein called the core antigen (HBcAg) which self-assembles into particles. The particles are highly immunogenic and are able to present heterologous epitopes to the immune system when the epitopes are inserted into a surface-exposed region of the particles called the “e1 loop”. The structural building blocks of the particles are tightly associated dimers of HBcAg in which the adjacent e1 loops are closely juxtaposed. It is proposed that sequences inserted into the e1 loop are conformationally restrained in the assembled particles when presented in monomeric core protein. The invention seeks to solve this problem by covalently linking core proteins as tandem copies (e.g., as dimers) so that insertions can be made independently in each copy. This is particularly useful for insertion of large sequences into the e1 loop because it allows such sequences to be inserted into just one copy of the core protein per tandem repeat, thereby reducing potential conformational clashes in assembly. Alternatively, a different sequence may be inserted into each e1 loop of a tandem repeat, thus increasing the flexibility of HBcAg particles as an epitope delivery system.

Abstract translation: 乙型肝炎病毒（HBV）衣壳由称为核心抗原（HBcAg）的单一种类的蛋白质组成，其自组装成颗粒。 当将表位插入称为“e1循环”的颗粒的表面暴露区域中时，颗粒是高度免疫原性的并且能够向免疫系统提供异源表位。 颗粒的结构构件是HBcAg的紧密相关的二聚体，其中相邻的e1环相互并置。 提出插入到e1环中的序列在单体核心蛋白中呈现时，在组装的颗粒中被构象地约束。 本发明寻求通过将核心蛋白质共价连接作为串联拷贝（例如，作为二聚体）来解决这个问题，从而可以在每个拷贝中独立地进行插入。 这对于将大序列插入到e1环中是特别有用的，因为它允许这样的序列插入到每个串联重复的核心蛋白的一个拷贝中，从而减少组装中潜在的构象冲突。 或者，可以将不同的序列插入到串联重复的每个e1环中，从而增加HBcAg颗粒作为表位递送系统的灵活性。

公开(公告)号：US5857952A

公开(公告)日：1999-01-12

申请号：US891534

申请日：1997-07-11

Applicant: Scott Robert Gilbert

Inventor： Scott Robert Gilbert

IPC: A47G7/08 ,  B44F1/08 ,  B65D30/28 ,  B31B1/90

CPC classification number: B44F1/08 ,  A47G7/085 ,  B65D31/18 ,  Y10S493/918 ,  Y10S493/934 ,  Y10S493/936

Abstract: A flat trapezoidal container provides a generally frustoconical single cavity for snugly sheathing a flower pot. The container is specifically dimensioned sheath a flower pot so as either (a) to leave therebeneath, a surplus of film in an transition zone which is concealable under the flower pot, or (b) form a hexagonal gusset in the bottom. The container is made from two flat panels of heat-sealable film, each shaped in the general form of a trapezium; or from a single web folded double. The lower portion of the container is ornamentally imprinted along a border extending beneath a generally lateral line above the longitudinal axis of the web; and, with a marker in the upper portion, identifies the contents, or provides instructions for their use or care. When the cavity is distended by being partially filled, the entire container, except for a transition zone, presents a smoothly arcuate surface of the frustum of a cone. The lower exterior portion is continuously printed with ornamental design elements without an interruption in the printing, such as is present as an elongated blank rectangle in prior art bags. The transparent upper portion is free from an elongated portion of the printed image near the edges, as in prior art containers. A method is disclosed for forming the printed container which method requires discarding the material for more than one-half of one container for each container made by thermally sealing the equally, but oppositely angulated sides of the trapeziums, and the shorter of the remaining parallel sides.

Abstract translation: 平坦的梯形容器提供一个大致截头圆锥形的单个空腔，用于紧密地覆盖花盆。 容器是特殊尺寸的护套，一个花盆，以便（a）离开，在过渡区域中剩余的膜可以隐藏在花盆下方，或（b）在底部形成六角形角撑板。 容器由两片可热封薄膜制成，每片均以梯形的一般形式成形; 或从单个网折叠双。 容器的下部沿着在幅材的纵向轴线上方的大致侧向线下方延伸的边界被装饰性地印记; 并且在上部标记标识内容，或提供使用或保养的说明。 当通过部分填充空腔时，除了过渡区域之外，整个容器呈锥形平截头体的平滑弧形表面。 下部外部部分连续印刷有装饰设计元件，而不会打印中断，例如在现有技术的袋子中呈现为细长的空白矩形。 像现有技术的容器一样，透明的上部部分没有靠近边缘的印刷图像的细长部分。 公开了一种用于形成印刷容器的方法，该方法需要为通过热密封梯形的相同但相对角度的侧面而制造的每个容器的一个以上的容器中的一半以上的材料丢弃，并且剩余的平行侧的较短的 。

公开(公告)号：US5647168A

公开(公告)日：1997-07-15

申请号：US610365

申请日：1996-03-04

Applicant: Scott Robert Gilbert

Inventor： Scott Robert Gilbert

IPC: A47G7/08 ,  B44F1/08 ,  B65D30/28 ,  A01G9/02

CPC classification number: B44F1/08 ,  A47G7/085 ,  B65D31/18 ,  Y10S493/918 ,  Y10S493/934 ,  Y10S493/936

Abstract: A flat trapezoidal container provides a generally frustoconical single cavity for snugly sheathing a flower pot. The container is specifically dimensioned sheath a flower pot so as either (a) to leave therebeneath, a surplus of film in an transition zone which is concealable under the flower pot, or (b) form a hexagonal gusset in the bottom. The container is made from two flat panels of heat-sealable film, each shaped in the general form of a trapezium; or from a single web folded double. The lower portion of the container is ornamentally imprinted along a border extending beneath a generally lateral line above the longitudinal axis of the web; and, with a marker in the upper portion, identifies the contents, or provides instructions for their use or care. When the cavity is distended by being partially filled, the entire container, except for a transition zone, presents a smoothly arcuate surface of the frustum of a cone. The lower exterior portion is continuously printed with ornamental design elements without an interruption in the printing, such as is present as an elongated blank rectangle in prior art bags. The transparent upper portion is free from an elongated portion of the printed image near the edges, as in prior art containers. A method is disclosed for forming the printed container which method requires discarding the material for more than one-half of one container for each container made by thermally sealing the equally, but oppositely angulated sides of the trapeziums, and the shorter of the remaining parallel sides.

Abstract translation: 平坦的梯形容器提供一个大致截头圆锥形的单个空腔，用于紧密地覆盖花盆。 容器是特殊尺寸的护套，一个花盆，以便（a）离开，在过渡区域中剩余的膜可以隐藏在花盆下方，或（b）在底部形成六角形角撑板。 容器由两片可热封薄膜制成，每片均以梯形的一般形式成形; 或从单个网折叠双。 容器的下部沿着在幅材的纵向轴线上方的大致侧向线下方延伸的边界被装饰性地印记; 并且在上部标记标识内容，或提供使用或保养的说明。 当通过部分填充空腔时，除了过渡区域之外，整个容器呈锥形平截头体的平滑弧形表面。 下部外部部分连续印刷有装饰设计元件，而不会打印中断，例如在现有技术的袋子中呈现为细长的空白矩形。 像现有技术的容器一样，透明的上部部分没有靠近边缘的印刷图像的细长部分。 公开了一种用于形成印刷容器的方法，该方法需要为通过热密封梯形的相同但相对角度的侧面而制造的每个容器的一个以上的容器中的一半以上的材料丢弃，并且剩余的平行侧的较短的 。

公开(公告)号：US5302082A

公开(公告)日：1994-04-12

申请号：US910243

申请日：1992-07-09

Applicant: Robert Gilbert

Inventor： Robert Gilbert

IPC: F04D7/04 ,  F04D29/22

CPC classification number: F04D29/2288 ,  F04D7/045

Abstract: A grinding pump for pumping liquid containing solid and semi-solid matter having an improved efficiency and which requires a lower operating rpm while exhibiting an increased flow rate. The pump includes: a housing having a chamber; a shaft rotatably disposed within the housing, a comminutor on the shaft within the housing and having a helical blade, and an impeller having a vane; and a shredding liner secured to the housing structure in the chamber, so as to cooperate with the comminutor and impeller vane in shredding and pulverizing the matter.

Abstract translation: 一种用于泵送含有固体和半固体物质的液体的研磨泵，其具有提高的效率，并且需要较低的操作转速，同时呈现增加的流速。 泵包括：具有腔室的壳体; 可旋转地设置在壳体内的轴，在壳体内的轴上的分配器，并具有螺旋叶片，以及具有叶片的叶轮; 以及固定到所述室中的所述壳体结构的切碎衬垫，以便与所述破碎机和叶轮叶片配合以粉碎和粉碎所述物质。

公开(公告)号：US5026246A

公开(公告)日：1991-06-25

申请号：US440935

申请日：1989-11-22

Applicant: Tod A. Bay ,  Jeffry R. Frahm ,  David F. Roesler ,  Robert Gilbert

Inventor： Tod A. Bay ,  Jeffry R. Frahm ,  David F. Roesler ,  Robert Gilbert

IPC: E02F9/22

CPC classification number: E02F9/2203

Abstract: A backhoe pivotally supported from a prime mover is disclosed wherein the hydraulic cylinders operably connected to the outrigger stabilizers are provided with a detent to maintain the outrigger stabilizers in an elevated transport position until being pressurized to extend the cylinders and, thereby, rotate the stabilizers into a ground engaging position. The detent is in the form of a projection extending inwardly from the barrel of the outrigger stabilizer cylinder and positioned for engagement with a deformable detent ring when the piston is moved to the fully retracted position. The detent includes a relief to permit the flow of hydraulic fluid past the engagement between the detent ring and the projection so that hydraulic cylinder will not become hydraulically locked.

Abstract translation: 公开了一种从原动机枢转地支撑的反铲，其中可操作地连接到外伸支架稳定器的液压缸设置有制动器，以将外伸支架稳定器保持在升高的运输位置，直到被加压以延伸气缸，并由此将稳定器旋转 地面接合位置。 制动器是从外伸支架稳定器筒的筒体向内延伸的突起的形式，并且当活塞移动到完全缩回位置时，其定位成与可变形的制动环接合。 制动器包括一个浮力，以允许液压流体流过止动环和突起之间的接合，使得液压缸不会变为液压锁定。

公开(公告)号：US20160115090A1

公开(公告)日：2016-04-28

申请号：US13905558

申请日：2013-05-30

Applicant: Jared D. Moretti ,  Jesse J. Sabatini ,  Gary Chen ,  Robert Gilbert, JR.

Inventor： Jared D. Moretti ,  Jesse J. Sabatini ,  Gary Chen ,  Robert Gilbert, JR.

IPC: C06B23/00 ,  C06D3/00

CPC classification number: C06D3/00

Abstract: A yellow smoke composition useful in hand held signals, such as the U.S. Army M194 yellow smoke parachute signal; which composition contains the nontoxic, environmentally safe, quinoline solvent yellow 33 color agent and critically exhibits the requisite dense yellow smoke for the requisite 9 to 18 second burn time upon use. Further, this inventive yellow smoke composition can be used in current metal tubes and in other media, such as biodegradable cardboard tubes.

Abstract translation: 一种黄色烟雾组合物可用于手持信号，如美国陆军M194黄色降落伞信号; 该组合物含有无毒，环保的喹啉溶剂黄33颜料，并且在使用时需要9至18秒燃烧时间，严格显示必需的浓黄色烟雾。 此外，本发明的黄烟组合物可用于当前的金属管和其它介质，例如可生物降解的纸板管。

公开(公告)号：US20140124024A1

公开(公告)日：2014-05-08

申请号：US13995040

申请日：2011-12-16

Applicant: Philippe Schottland ,  Jin-an He ,  Christelle Conan ,  Robert Gilbert ,  Carl Carter ,  Robert Mateuszezyk

Inventor： Philippe Schottland ,  Jin-an He ,  Christelle Conan ,  Robert Gilbert ,  Carl Carter ,  Robert Mateuszezyk

IPC: H01L31/0224 ,  H01L31/18

CPC classification number: H01L31/022425 ,  H01B1/22 ,  H01L31/18 ,  Y02E10/50

Abstract: The present invention describes an aluminum-based paste composition including an aluminum powder, one or more glass frits, an organo-aluminate compound; and an organic vehicle. The present invention also describes a solar cell including an aluminum-based paste composition applied on a back surface of a silicon wafer.

Abstract translation: 本发明描述了一种铝基糊剂组合物，其包含铝粉末，一种或多种玻璃料，有机铝酸盐化合物; 和有机车辆。 本发明还描述了一种太阳能电池，其包括施加在硅晶片的背面上的铝基糊剂组合物。

公开(公告)号：US20110066297A1

公开(公告)日：2011-03-17

申请号：US12993780

申请日：2009-05-20

Applicant: Ali Saberi ,  James Robert Gilbert ,  Kevin Lay

Inventor： Ali Saberi ,  James Robert Gilbert ,  Kevin Lay

IPC: G06F1/28 ,  G06F1/26

CPC classification number: F16K37/0091 ,  F16K31/046

Abstract: A remote monitoring and control system comprising synchronized wireless MESH technology for remote monitoring and control of utility grids (e.g., utility meters), commodity distribution networks, industrial equipment, and infrastructure including remote disconnection/connection and self-generating power.

Abstract translation: 远程监视和控制系统包括用于远程监视和控制公用电网（例如，公用事业电表），商品分配网络，工业设备和基础设施的同步无线MESH技术，包括远程断开/连接和自发电力。

公开(公告)号：US20080206049A1

公开(公告)日：2008-08-28

申请号：US11962852

申请日：2007-12-21

Applicant: David Robert Gilbert Depaepe ,  Philippe Ernst

Inventor： David Robert Gilbert Depaepe ,  Philippe Ernst

IPC: F04D29/56

CPC classification number: F04D29/542 ,  F01D9/042 ,  F01D17/162 ,  F01D25/246 ,  F04D29/644 ,  F05D2230/64 ,  F05D2240/128 ,  F05D2250/182 ,  F05D2250/70 ,  F05D2260/30

Abstract: A straightener blade for a turbomachine, comprising a platform arranged at a radially external end of the blade and adapted to be engaged in a annular groove of a housing, and a threaded rod radially extending outwardly from the platform and adapted to pass through an orifice of the housing in order to receive a fixing nut, the upstream and downstream edges of the platform each comprising a protrusion extending in the plan of the platform in order to limit the rotation of the platform in the groove when the nut screwed on the threaded rod is tightened.

Abstract translation: 一种用于涡轮机的矫直机叶片，包括平台，该平台布置在叶片的径向外端并且适于接合在壳体的环形槽中，以及从该平台向外径向延伸的螺杆， 所述壳体为了接收固定螺母，所述平台的上游和下游边缘各自包括在所述平台的平面中延伸的突起，以便当所述螺母拧在所述螺杆上时限制所述平台在所述凹槽中的旋转， 收紧

公开(公告)号：US20070007919A1

公开(公告)日：2007-01-11

申请号：US11175070

申请日：2005-07-05

Applicant: Mike Blossfeld ,  Robert Gilbert

Inventor： Mike Blossfeld ,  Robert Gilbert

IPC: H02P1/00

CPC classification number: H01H23/006 ,  H01H23/168 ,  H01H2300/01

Abstract: An apparatus for controlling an electric motor (14) for, when energized, moving a vehicle window (22) selectively up or down and selectively in an auto up or auto down mode. The apparatus includes an electrical circuit electrically coupled to the electric motor (14) to energize the electrical motor (14) to move the window (22) toward one of the fully open and fully closed positions. The circuit includes a printed circuit board (46) and a first switch (10) for selectively energizing the electrical motor (14). An actuator (32) is movable to actuate the first switch (10) to actuate the electrical motor (14). A second switch (200) for selectively energizing the electrical motor (14) in an auto function mode is activated by a member (150) extending through the printed circuit board (46).

Abstract translation: 一种用于控制电动机（14）的装置，用于当被激励时，以自动向上或自动下降模式选择性地向上或向下地选择性地移动车辆窗口（22）。 该装置包括电耦合到电动机（14）的电路，以使电动机（14）激励以将窗口（22）朝向完全打开和完全关闭位置之一移动。 电路包括用于选择性地激励电动机（14）的印刷电路板（46）和第一开关（10）。 致动器（32）可移动以致动第一开关（10）以致动电动机（14）。 用于以自动功能模式选择性地激励电动机（14）的第二开关（200）由延伸穿过印刷电路板（46）的构件（150）激活。