-
公开(公告)号：US07521438B1
公开(公告)日：2009-04-21
申请号：US10089449
申请日：2000-09-26
申请人： Istvan Szelenyi , Hildegard Kuss , Sabine Heer , Juergen Engel
发明人： Istvan Szelenyi , Hildegard Kuss , Sabine Heer , Juergen Engel
IPC分类号： A61K31/56
CPC分类号： A61K9/0075 , A61K31/167 , A61K31/56 , A61K45/06 , Y10S514/826 , A61K2300/00
摘要： The invention relates to a novel combination of a soft steroid, in particular loteprednol, and at least one β2 adrenoceptor agonist for the simultaneous, sequential or separate treatment of allergies and/or airway disorders, medicaments comprising the combination, processes for the production of such medicaments and the use of the novel combination for the production of medicaments for the simultaneous, sequential or separate treatment of allergies and/or airway disorders.
摘要翻译： 本发明涉及软类固醇，特别是碘苯醇和与过敏和/或气道障碍的同时，连续或分开治疗的至少一种β2肾上腺素受体激动剂的新组合，包含该组合的药物， 药物和用于生产用于同时，连续或分开地治疗过敏和/或气道障碍的药物的新型组合的用途。
-
2.发明授权Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation 失效羟基吲哚，它们用作磷酸二酯酶4的抑制剂及其制备方法公开(公告)号：US07161009B2
公开(公告)日：2007-01-09
申请号：US10081642
申请日：2002-02-21
申请人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号： C07D401/12
CPC分类号： C07D209/22 , C07D209/24 , C07D401/12
摘要： The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
摘要翻译： 本发明涉及式的新型羟基吲哚，它们用作磷酸二酯酶4的抑制剂及其制备方法。
-
3.发明授权公开(公告)号：US06613794B2
公开(公告)日：2003-09-02
申请号：US10347659
申请日：2003-01-20
申请人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号： A61K31405
CPC分类号： C07D209/22 , C07D209/24 , C07D401/12
摘要： The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
-
公开(公告)号：US07022687B1
公开(公告)日：2006-04-04
申请号：US10089436
申请日：2000-09-26
申请人： Istvan Szelenyl , Degenhard Marx , Sabine Heer , Juergen Engel
发明人： Istvan Szelenyl , Degenhard Marx , Sabine Heer , Juergen Engel
CPC分类号： A61K45/06 , A61K31/56 , A61K2300/00
摘要： The present invention relates to a novel combination of a soft steroid, in particular loteprednol, and at least one antihistamine, such as, for example, azelastine and/or levocabastine, for simultaneous, sequential or separate administration in the local treatment of allergies and airway disorders, for example of allergic rhinitis (rhinoconjunctivitis).
摘要翻译： 本发明涉及柔软类固醇，特别是碘苯醇和至少一种抗组胺药，例如氮卓斯汀和/或左卡巴斯坦，用于在过敏和气道的局部治疗中同时，连续或分开施用的新型组合 疾病，例如过敏性鼻炎（鼻结膜炎）。
-
5.再颁专利Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation 失效羟基吲哚，它们用作磷酸二酯酶4的抑制剂及其制备方法公开(公告)号：USRE38624E1
公开(公告)日：2004-10-12
申请号：US10176435
申请日：2002-09-19
申请人： Norbert Hofgen , Ute Egerland , Hildegard Kuss , Degenhard Marx , Stefan Szelenyi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人： Norbert Hofgen , Ute Egerland , Hildegard Kuss , Degenhard Marx , Stefan Szelenyi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号： A61K314439
CPC分类号： C07D209/22 , C07D209/24 , C07D401/12
摘要： The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
-
6.发明授权Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation 有权羟基吲哚，它们用作磷酸二酯酶4的抑制剂及其制备方法公开(公告)号：US06251923B1
公开(公告)日：2001-06-26
申请号：US09300973
申请日：1999-04-28
申请人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号： A61K314439
CPC分类号： C07D209/22 , C07D209/24 , C07D401/12
摘要： The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
摘要翻译： 本发明涉及式的新型羟基吲哚，它们用作磷酸二酯酶4的抑制剂及其制备方法。
-
7.发明授权3-cyano-5,4'-bipyridine-1'-oxide compounds and pharmaceutical compositions and methods containing the same 失效3-氰基-5,4'-联吡啶-1'-氧化物化合物和药物组合物及其含有的方法
公开(公告)号：US5162533A
公开(公告)日：1992-11-10
申请号：US665682
申请日：1991-03-07
申请人： Erhard Klauschenz , Volker Hagen , Angela Hagen , Peter Muschick , Brigitte Schlegel , Sabine Heer , Gottfried Faust , Hans-Joachim Jansch
发明人： Erhard Klauschenz , Volker Hagen , Angela Hagen , Peter Muschick , Brigitte Schlegel , Sabine Heer , Gottfried Faust , Hans-Joachim Jansch
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/444 , A61K31/495 , A61K31/535 , A61P9/04 , A61P9/08 , C07D213/89
CPC分类号： C07D213/89
摘要： A 3-cyano-5,4'-bipyridine-1'-oxide of the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R is an amino, alkoxy, oxyalkoxy or chloro residue, have heart stimulating cardiotonic and vasodiolatory properties. They can be preparaed by (a) converting an R-substituted-3-cyano-bipyridine to its corresponding N-oxide, or (b) by substituting an R-residue or an R-unsubstituted precursor of the conpound of fomula (i), and if required, converting the product into its pharmaceutically acceptable acid addition salt.
摘要翻译： 式（I）的3-氰基-5,4'-联吡啶-1'-氧化物及其药学上可接受的酸加成盐，其中R是氨基，烷氧基，氧代烷氧基或氯代残基，具有心脏刺激强心剂 和血管舒张特性。 它们可以通过（a）将R-取代的3-氰基 - 联吡啶转化成其相应的N-氧化物来制备，或（b）通过用式（ⅰ）的R-残基或R-未取代的前体代替， ，如果需要，将产物转化为其药学上可接受的酸加成盐。
-
8.发明授权Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation 失效羟基吲哚，它们用作磷酸二酯酶4的抑制剂及其制备方法公开(公告)号：US06545158B2
公开(公告)日：2003-04-08
申请号：US10081395
申请日：2002-02-21
申请人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号： C07D40106
CPC分类号： C07D209/22 , C07D209/24 , C07D401/12
摘要： The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
摘要翻译： 本发明涉及式的新型羟基吲哚，它们用作磷酸二酯酶4的抑制剂及其制备方法。
-
9.发明授权Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and processes for their preparation 失效羟基吲哚，它们用作磷酸二酯酶4的抑制剂及其制备方法公开(公告)号：US06545025B2
公开(公告)日：2003-04-08
申请号：US10080821
申请日：2002-02-21
申请人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号： A61K314439
CPC分类号： C07D209/22 , C07D209/24 , C07D401/12
摘要： The invention relates to nets hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
摘要翻译： 本发明涉及式的N-羟基吲哚，它们作为磷酸二酯酶4的抑制剂的用途及其制备方法。
-
10.发明授权公开(公告)号：US06602890B2
公开(公告)日：2003-08-05
申请号：US10081807
申请日：2002-02-21
申请人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
发明人： Norbert Höfgen , Ute Egerland , Hildegard Poppe , Degenhard Marx , Stefan Szelényi , Thomas Kronbach , Emmanuel Polymeropoulos , Sabine Heer
IPC分类号： C07D40106
CPC分类号： C07D209/22 , C07D209/24 , C07D401/12
摘要： The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.016 秒)
