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1.发明授权公开(公告)号：US06638913B1
公开(公告)日：2003-10-28
申请号：US09504108
申请日：2000-02-14
IPC分类号： A01N4304
CPC分类号： A61K49/0452 , A61K9/0019 , A61K45/06 , A61K47/02 , A61K47/183
摘要： Additives to concentrated injection and infusion solutions that avoid or mitigate acute or delayed hypersensitivity reactions as well as injection and infusion solutions that contain these additives are described.
摘要翻译： 描述了避免或减轻急性或延迟性超敏反应的浓缩注射和输注溶液的添加剂以及含有这些添加剂的注射和输注溶液。
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2.发明申请公开(公告)号：US20110027179A1
公开(公告)日：2011-02-03
申请号：US12904433
申请日：2010-10-14
申请人： Matthias FRIEBE , Peter Muschick , Andreas Huth
发明人： Matthias FRIEBE , Peter Muschick , Andreas Huth
IPC分类号： A61K51/04 , C07C237/34 , C07D317/68 , C07D295/195 , C07C229/22 , C07C311/08 , A61P35/00
CPC分类号： A61K51/04 , C07B2200/05 , C07C237/44 , C07C311/08 , C07C311/48 , C07D295/15 , C07D317/68
摘要： This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with respect to tumor concentration and retardation, liver concentration and blood accumulation. The radiation-therapy doses to be achieved in the tumor, compared to healthy body tissue, are advantageous for the compounds according to the invention.
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3.发明申请Radiohalogenated Benzamide Derivatives And Their Use In Tumor Diagnosis And Tumor Therapy 有权放射性卤代苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用公开(公告)号：US20090012090A1
公开(公告)日：2009-01-08
申请号：US12207774
申请日：2008-09-10
申请人： Matthias Friebe , Peter Muschick , Andreas Huth
发明人： Matthias Friebe , Peter Muschick , Andreas Huth
IPC分类号： A61K31/5375 , A61K31/165 , A61K31/235 , A61P35/00 , A61K31/36
CPC分类号： A61K51/04 , A61K51/0425 , A61K51/0463
摘要： This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with respect to tumor concentration and retardation, liver concentration and blood accumulation. The radiation-therapy doses to be achieved in the tumor, compared to healthy body tissue, are advantageous for the compounds according to the invention.
摘要翻译： 本发明涉及新的放射性卤代苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用。 根据本发明的放射性卤代苯甲酰胺衍生物显示出新的和特别有利的特性，特别是关于肿瘤浓度和延迟，肝脏浓度和血液积聚。 与健康的身体组织相比，在肿瘤中实现的放射治疗剂量对于本发明的化合物是有利的。
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4.发明授权Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy 失效放射性卤代苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用公开(公告)号：US07427390B2
公开(公告)日：2008-09-23
申请号：US11076023
申请日：2005-03-10
申请人： Matthias Friebe , Peter Muschick , Andreas Huth
发明人： Matthias Friebe , Peter Muschick , Andreas Huth
CPC分类号： A61K51/04 , A61K51/0425 , A61K51/0463
摘要： This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with respect to tumor concentration and retardation, liver concentration and blood accumulation. The radiation-therapy doses to be achieved in the tumor, compared to healthy body tissue, are advantageous for the compounds according to the invention.
摘要翻译： 本发明涉及新的放射性卤代苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用。 根据本发明的放射性卤代苯甲酰胺衍生物显示出新的和特别有利的特性，特别是关于肿瘤浓度和延迟，肝脏浓度和血液积聚。 与健康的身体组织相比，在肿瘤中实现的放射治疗剂量对于本发明的化合物是有利的。
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5.发明申请Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy 失效放射性卤代苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用公开(公告)号：US20050207972A1
公开(公告)日：2005-09-22
申请号：US11076023
申请日：2005-03-10
申请人： Matthias Friebe , Peter Muschick , Andreas Huth
发明人： Matthias Friebe , Peter Muschick , Andreas Huth
CPC分类号： A61K51/04 , A61K51/0425 , A61K51/0463
摘要： This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with respect to tumor concentration and retardation, liver concentration and blood accumulation. The radiation-therapy doses to be achieved in the tumor, compared to healthy body tissue, are advantageous for the compounds according to the invention.
摘要翻译： 本发明涉及新的放射性卤代苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用。 根据本发明的放射性卤代苯甲酰胺衍生物显示出新的和特别有利的特性，特别是关于肿瘤浓度和延迟，肝脏浓度和血液积聚。 与健康的身体组织相比，在肿瘤中实现的放射治疗剂量对于本发明的化合物是有利的。
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6.发明申请Radiohalogenated Benzamide Derivatives And Their Use In Tumor Diagnosis And Tumor Therapy 审中-公开放射性卤代苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用公开(公告)号：US20110052492A1
公开(公告)日：2011-03-03
申请号：US12938783
申请日：2010-11-03
申请人： Matthias FRIEBE , Peter Muschick , Andreas Huth
发明人： Matthias FRIEBE , Peter Muschick , Andreas Huth
IPC分类号： A61K51/04 , A61K31/5375 , A61K31/36 , A61K31/18 , A61K31/167 , C07D265/30 , C07D317/60 , C07C311/48 , C07C237/44 , A61P35/00
CPC分类号： A61K51/04 , C07B2200/05 , C07C237/44 , C07C311/08 , C07C311/48 , C07D295/15 , C07D317/68
摘要： This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with respect to tumor concentration and retardation, liver concentration and blood accumulation. The radiation-therapy doses to be achieved in the tumor, compared to healthy body tissue, are advantageous for the compounds according to the invention.
摘要翻译： 本发明涉及新的放射性卤代苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用。 根据本发明的放射性卤代苯甲酰胺衍生物显示出新的和特别有利的特性，特别是关于肿瘤浓度和延迟，肝脏浓度和血液积聚。 与健康的身体组织相比，在肿瘤中实现的放射治疗剂量对于本发明的化合物是有利的。
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7.发明授权Radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy 有权放射性卤代苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用公开(公告)号：US07850948B2
公开(公告)日：2010-12-14
申请号：US12207774
申请日：2008-09-10
申请人： Matthias Friebe , Peter Muschick , Andreas Huth
发明人： Matthias Friebe , Peter Muschick , Andreas Huth
CPC分类号： A61K51/04 , A61K51/0425 , A61K51/0463
摘要： This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with respect to tumor concentration and retardation, liver concentration and blood accumulation. The radiation-therapy doses to be achieved in the tumor, compared to healthy body tissue, are advantageous for the compounds according to the invention.
摘要翻译： 本发明涉及新的放射性卤代苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用。 根据本发明的放射性卤代苯甲酰胺衍生物显示出新的和特别有利的特性，特别是关于肿瘤浓度和延迟，肝脏浓度和血液积聚。 与健康的身体组织相比，在肿瘤中实现的放射治疗剂量对于本发明的化合物是有利的。
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8.发明授权
公开(公告)号：US5874422A
公开(公告)日：1999-02-23
申请号：US945857
申请日：1998-01-27
申请人： Werner Krause , Peter Muschick
发明人： Werner Krause , Peter Muschick
IPC分类号： A61K9/127 , A61K31/19 , A61K31/192 , A61K31/405 , A61K31/60 , A61K45/00 , A61K45/06 , A61K45/08 , A61K49/00 , A61K49/04 , A61K49/18 , A61P29/00
CPC分类号： A61K31/616 , A61K31/192 , A61K31/405 , A61K45/06 , A61K49/1812 , A61K9/127
摘要： The use of nonsteroidal anti-inflammatory agents as an addition to particulate pharmaceutical agent preparations can reduce side-effects on the cardiovascular system during administration.
摘要翻译： PCT No.PCT / EP96 / 01936 Sec。 371日期：1998年1月27日 102（e）日期1998年1月27日PCT提交1996年5月9日PCT公布。 第WO96 / 35429号PCT公开 日期1996年11月14日使用非甾体抗炎药作为颗粒药剂制剂的添加剂可减少给药期间对心血管系统的副作用。
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公开(公告)号：US5756066A
公开(公告)日：1998-05-26
申请号：US487096
申请日：1995-06-07
申请人： Danute Nitecki , Werner Krause , Franz-Karl Maier , Gabriele Schuhmann-Giampieri , Wolf-Rudiger Press , Peter Muschick , Sara Biancalana
发明人： Danute Nitecki , Werner Krause , Franz-Karl Maier , Gabriele Schuhmann-Giampieri , Wolf-Rudiger Press , Peter Muschick , Sara Biancalana
CPC分类号： A61K49/0442 , C07K14/001 , A61K38/00
摘要： Iodine-containing peptides of general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, a, m and q have the meanings indicated in the description, agents containing these compounds, the use of compounds as contrast media as well as processes for their production are described.
摘要翻译： 其中R1，R2，R3，R4，a，m和q具有说明书中所示含义的含有I的通式I（I）的肽，含有这些化合物的试剂，化合物作为造影剂的使用 以及其生产过程。
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10.发明授权3-cyano-5,4'-bipyridine-1'-oxide compounds and pharmaceutical compositions and methods containing the same 失效3-氰基-5,4'-联吡啶-1'-氧化物化合物和药物组合物及其含有的方法
公开(公告)号：US5162533A
公开(公告)日：1992-11-10
申请号：US665682
申请日：1991-03-07
申请人： Erhard Klauschenz , Volker Hagen , Angela Hagen , Peter Muschick , Brigitte Schlegel , Sabine Heer , Gottfried Faust , Hans-Joachim Jansch
发明人： Erhard Klauschenz , Volker Hagen , Angela Hagen , Peter Muschick , Brigitte Schlegel , Sabine Heer , Gottfried Faust , Hans-Joachim Jansch
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4412 , A61K31/444 , A61K31/495 , A61K31/535 , A61P9/04 , A61P9/08 , C07D213/89
CPC分类号： C07D213/89
摘要： A 3-cyano-5,4'-bipyridine-1'-oxide of the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R is an amino, alkoxy, oxyalkoxy or chloro residue, have heart stimulating cardiotonic and vasodiolatory properties. They can be preparaed by (a) converting an R-substituted-3-cyano-bipyridine to its corresponding N-oxide, or (b) by substituting an R-residue or an R-unsubstituted precursor of the conpound of fomula (i), and if required, converting the product into its pharmaceutically acceptable acid addition salt.
摘要翻译： 式（I）的3-氰基-5,4'-联吡啶-1'-氧化物及其药学上可接受的酸加成盐，其中R是氨基，烷氧基，氧代烷氧基或氯代残基，具有心脏刺激强心剂 和血管舒张特性。 它们可以通过（a）将R-取代的3-氰基 - 联吡啶转化成其相应的N-氧化物来制备，或（b）通过用式（ⅰ）的R-残基或R-未取代的前体代替， ，如果需要，将产物转化为其药学上可接受的酸加成盐。
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