公开(公告)号：US20160228612A1

公开(公告)日：2016-08-11

申请号：US15131695

申请日：2016-04-18

申请人： Samin Eftekhari

发明人： Samin Eftekhari ,  Habiba Bougherara

IPC分类号： A61L27/48 ,  A61L27/46 ,  A61L27/56

CPC分类号： A61L27/48 ,  A61L27/46 ,  A61L27/56 ,  A61L31/127 ,  A61L31/129 ,  A61L31/146 ,  A61L2400/12 ,  A61L2430/02 ,  D01D5/00 ,  C08L67/04

摘要： A composition suitable for bone replacement is provided. The composition is a nanocomposite matrix, resembling both the structure and the properties of natural bone, including morphology, composition and mechanical characteristics. The nanocomposite is preferably porous and comprises: (1) micro or nano scale cellulose crystals or fibres; (2) hydroxyapatite nanoparticles; (3) Poly L-Lactide Acid or poly glycolic acid; and (4) a coupling agent, for example a surfactant, preferably an anionic surfactant such as sodium dodecyl sulfate. The composition is useful as an artificial bone replacement or bone graft, is preferably biomimetic, and can be suitable for use, for example, in trabecular bone substitution and osteoanagenesis applications. A method of fabrication of the nanocomposite is also provided.

公开(公告)号：US20150231304A1

公开(公告)日：2015-08-20

申请号：US14684939

申请日：2015-04-13

申请人： Samin Eftekhari

发明人： Samin Eftekhari ,  Habiba Bougherara

IPC分类号： A61L27/48 ,  A61L27/56 ,  D01D5/00 ,  A61L27/46

CPC分类号： A61L27/48 ,  A61L27/46 ,  A61L27/56 ,  A61L31/127 ,  A61L31/129 ,  A61L31/146 ,  A61L2400/12 ,  A61L2430/02 ,  D01D5/00 ,  C08L67/04

摘要： A composition suitable for bone replacement is provided. The composition is a nanocomposite matrix, resembling both the structure and the properties of natural bone, including morphology, composition and mechanical characteristics. The nanocomposite is preferably porous and comprises: (1) micro or nano scale cellulose crystals or fibres; (2) hydroxyapatite nanoparticles; (3) Poly L-Lactide Acid or poly glycolic acid; and (4) a coupling agent, for example a surfactant, preferably an anionic surfactant such as sodium dodecyl sulfate. The composition is useful as an artificial bone replacement or bone graft, is preferably biomimetic, and can be suitable for use, for example, in trabecular bone substitution and osteoanagenesis applications. A method of fabrication of the nanocomposite is also provided.

摘要翻译： 提供了适合于骨替代的组合物。 该组合物是纳米复合物基质，类似天然骨的结构和性质，包括形态，组成和机械特性。 纳米复合材料优选是多孔的，并且包括：（1）微米或纳米级纤维素晶体或纤维; （2）羟基磷灰石纳米粒子; （3）聚L-丙交酯酸或聚乙醇酸; 和（4）偶联剂，例如表面活性剂，优选阴离子表面活性剂如十二烷基硫酸钠。 组合物可用作人造骨置换或骨移植，优选是仿生的，并且可适用于例如小梁骨取代和骨诱导应用。 还提供了纳米复合材料的制造方法。

公开(公告)号：US09327053B2

公开(公告)日：2016-05-03

申请号：US14684939

申请日：2015-04-13

申请人： Samin Eftekhari

发明人： Samin Eftekhari ,  Habiba Bougherara

IPC分类号： A61L27/46 ,  A61L27/48 ,  A61L27/56 ,  D01D5/00 ,  A61L31/12 ,  A61L31/14

CPC分类号： A61L27/48 ,  A61L27/46 ,  A61L27/56 ,  A61L31/127 ,  A61L31/129 ,  A61L31/146 ,  A61L2400/12 ,  A61L2430/02 ,  D01D5/00 ,  C08L67/04

摘要： A composition suitable for bone replacement is provided. The composition is a nanocomposite matrix, resembling both the structure and the properties of natural bone, including morphology, composition and mechanical characteristics. The nanocomposite is preferably porous and comprises: (1) micro or nano scale cellulose crystals or fibers; (2) hydroxyapatite nanoparticles; (3) Poly L-Lactide Acid or poly glycolic acid; and (4) a coupling agent, for example a surfactant, preferably an anionic surfactant such as sodium dodecyl sulfate. The composition is useful as an artificial bone replacement or bone graft, is preferably biomimetic, and can be suitable for use, for example, in trabecular bone substitution and osteoanagenesis applications. A method of fabrication of the nanocomposite is also provided.

摘要翻译： 提供了适合于骨替代的组合物。 该组合物是纳米复合物基质，类似天然骨的结构和性质，包括形态，组成和机械特性。 纳米复合材料优选是多孔的，并且包括：（1）微米或纳米级纤维素晶体或纤维; （2）羟基磷灰石纳米粒子; （3）聚L-丙交酯酸或聚乙醇酸; 和（4）偶联剂，例如表面活性剂，优选阴离子表面活性剂如十二烷基硫酸钠。 组合物可用作人造骨置换或骨移植，优选是仿生的，并且可适用于例如小梁骨取代和骨诱导应用。 还提供了纳米复合材料的制造方法。