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    Artificial bone nanocomposite and method of manufacture
    2.
    发明授权
    Artificial bone nanocomposite and method of manufacture 有权
    人造骨纳米复合材料及其制造方法

    公开(公告)号：US09327053B2

    公开(公告)日：2016-05-03

    申请号：US14684939

    申请日：2015-04-13

    申请人： Samin Eftekhari

    发明人： Samin Eftekhari ,  Habiba Bougherara

    IPC分类号： A61L27/46 ,  A61L27/48 ,  A61L27/56 ,  D01D5/00 ,  A61L31/12 ,  A61L31/14

    CPC分类号： A61L27/48 ,  A61L27/46 ,  A61L27/56 ,  A61L31/127 ,  A61L31/129 ,  A61L31/146 ,  A61L2400/12 ,  A61L2430/02 ,  D01D5/00 ,  C08L67/04

    摘要： A composition suitable for bone replacement is provided. The composition is a nanocomposite matrix, resembling both the structure and the properties of natural bone, including morphology, composition and mechanical characteristics. The nanocomposite is preferably porous and comprises: (1) micro or nano scale cellulose crystals or fibers; (2) hydroxyapatite nanoparticles; (3) Poly L-Lactide Acid or poly glycolic acid; and (4) a coupling agent, for example a surfactant, preferably an anionic surfactant such as sodium dodecyl sulfate. The composition is useful as an artificial bone replacement or bone graft, is preferably biomimetic, and can be suitable for use, for example, in trabecular bone substitution and osteoanagenesis applications. A method of fabrication of the nanocomposite is also provided.

    摘要翻译： 提供了适合于骨替代的组合物。 该组合物是纳米复合物基质，类似天然骨的结构和性质，包括形态，组成和机械特性。 纳米复合材料优选是多孔的，并且包括：（1）微米或纳米级纤维素晶体或纤维; （2）羟基磷灰石纳米粒子; （3）聚L-丙交酯酸或聚乙醇酸; 和（4）偶联剂，例如表面活性剂，优选阴离子表面活性剂如十二烷基硫酸钠。 组合物可用作人造骨置换或骨移植，优选是仿生的，并且可适用于例如小梁骨取代和骨诱导应用。 还提供了纳米复合材料的制造方法。

    COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY 有权
    用于核酸递送的组合物和方法

    公开(公告)号：US20140302116A1

    公开(公告)日：2014-10-09

    申请号：US14201615

    申请日：2014-03-07

    申请人： Massachusetts Institute of Technology

    发明人： Steven A. Castleberry ,  Paula T. Hammond

    IPC分类号： A61K9/70 ,  A61K31/713

    CPC分类号： A61K45/06 ,  A61K31/7105 ,  A61L27/12 ,  A61L27/22 ,  A61L27/46 ,  A61L31/026 ,  A61L31/047 ,  A61L31/127 ,  A61L31/16 ,  A61L2400/12 ,  A61L2420/08

    摘要： The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure includes a substrate; and a multilayer film coated on the substrate, wherein adjacent layers of the multilayer film are associated with one another via one or more non-covalent interactions, wherein the multilayer film comprises a first nucleic acid agent present at a loading density, and further wherein the multilayer film is characterized in that, when the structure is placed on a subject so that the multilayer film contacts cells, the first nucleic acid agent is released with a profile characterized by a feature selected from the group consisting of 1) being a burst-free release; 2) being a sustained release; and 3) exhibiting in vitro and/or in vivo biological effectiveness.

    摘要翻译： 本发明尤其提供了多层膜涂料组合物，涂覆的基材及其方法。 在一些实施例中，结构包括基底; 以及涂覆在所述基底上的多层膜，其中所述多层膜的相邻层通过一种或多种非共价相互作用彼此相关联，其中所述多层膜包含以负载密度存在的第一核酸试剂，并且其中 多层膜的特征在于，当将结构放置在受试者上使得多层膜与细胞接触时，第一核酸试剂以具有选自以下的特征的轮廓被释放：1）是无突变的 发布; 2）持续释放; 和3）展现体外和/或体内生物学效力。

    Techniques For Increasing The Acoustic Impedance Of The Cochlea's Round Window Membrane
    7.
    发明申请
    Techniques For Increasing The Acoustic Impedance Of The Cochlea's Round Window Membrane 审中-公开
    用于增加耳蜗圆形窗膜阻抗的技术

    公开(公告)号：US20140172099A1

    公开(公告)日：2014-06-19

    申请号：US13714216

    申请日：2012-12-13

    申请人： OtoKinetics Inc.

    发明人： S. George Lesinski ,  Gregory N. Koskowich

    IPC分类号： A61F2/18 ,  A61L27/24

    CPC分类号： A61F2/18 ,  A61F2002/183 ,  A61L31/005 ,  A61L31/026 ,  A61L31/044 ,  A61L31/127 ,  A61L2430/14 ,  C08L89/06

    摘要： A method for increasing the acoustic impedance of the round window membrane of the cochlea in a human patient includes surgically opening access to the round window membrane and placing a packing layer over the round window membrane. Optionally a layer of collagen graft may be obtained from the patient and placed between the round window membrane and the packing layer. Optionally the packing layer may be enclosed within the collagen graft. Optionally bone paté may be obtained from the patient and used to form at least a portion of the packing layer. Optionally a silastic buttress may be placed under compression between the packing layer and the bone of sinus tympani of the patient.

    摘要翻译： 一种用于增加人类患者耳蜗的圆形窗膜的声阻抗的方法包括手术打开进入圆窗膜并将包装层放置在圆窗膜上。 任选地，可以从患者获得胶原移植物层并且放置在圆窗膜和包装层之间。 任选地，包装层可以封装在胶原移植物内。 任选地，可以从患者获得骨paté，并用于形成填充层的至少一部分。 任选地，可以在填充层和患者的窦鼓膜的骨之间的压缩下放置硅橡胶支撑。

    RESORBABLE AND RADIOPAQUE DEVICE FOR BONE FIXATION
    8.
    发明申请
    RESORBABLE AND RADIOPAQUE DEVICE FOR BONE FIXATION 有权
    用于骨固定的可变和放射性装置

    公开(公告)号：US20140039562A1

    公开(公告)日：2014-02-06

    申请号：US13603544

    申请日：2012-09-05

    申请人： Alain LEONARD ,  Carole LEONARD ,  Cyril SENDER ,  Olivier LIGNON ,  Gautier HALBIN ,  Nouredine SAHRAOUI

    发明人： Alain LEONARD ,  Carole LEONARD ,  Cyril SENDER ,  Olivier LIGNON ,  Gautier HALBIN ,  Nouredine SAHRAOUI

    IPC分类号： A61B17/80

    CPC分类号： A61L31/127 ,  A61L31/128 ,  A61L31/14 ,  A61L31/148 ,  A61L31/18 ,  A61L2430/02 ,  C08L67/04 ,  C08L69/00

    摘要： An osteosynthesis device that is both resorbable and radiopaque, produced using gradually degrading materials, includes at least one plate and a set of screws made of resorbable material, in which the plate consists of a composite mixture including i) a resorbable polymer or copolymer compound and ii) an inorganic filler that consists of at least one resorbable ceramic. The screws can be made of resorbable polymer, or of a composite mixture with at least one resorbable ceramic. The device is totally resorbable and radiopaque, and it offers a high level of safety, ensuring a strong and durable fixation of the screws to the plate and in the bone during the entire period needed for bone uniting.

    摘要翻译： 使用逐渐降解材料生产的可再吸收和不透射线的骨接合装置包括至少一个板和一组由可再吸收材料制成的螺钉，其中该板由复合混合物组成，复合混合物包括i）可再吸收的聚合物或共聚物化合物和 ii）由至少一种可吸收陶瓷组成的无机填料。 螺钉可以由可再吸收的聚合物制成，或者与至少一种可吸收陶瓷的复合混合物制成。 该装置是完全可吸收的和不透射线的，它提供了高水平的安全性，确保在骨骼联合所需的整个时间段内将螺钉牢固耐用地固定在板和骨骼上。