公开(公告)号：US07862819B2

公开(公告)日：2011-01-04

申请号：US10446441

申请日：2003-05-27

申请人： Sylvaine Cases ,  Robert V. Farese ,  Scot J. Stone ,  Ping Zhou

发明人： Sylvaine Cases ,  Robert V. Farese ,  Scot J. Stone ,  Ping Zhou

IPC分类号： A61K39/395 ,  C12N9/10 ,  C12N15/09

CPC分类号： C12N9/1029 ,  A01K2217/05 ,  A61K38/00 ,  A61K2039/505 ,  C12Y203/0102 ,  C12Y203/01022

摘要： Nucleic acid compositions encoding mammalian DGAT2α polypeptide products with diglyceride acyltransferase activity, as well as the mammalian DGAT2α polypeptide products encoded thereby and methods for producing the same, are provided. The subject DGAT2α polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications, as well as in treatment therapies and in the production of triacylglycerols.

摘要翻译： 提供了编码具有甘油二酯酰基转移酶活性的哺乳动物DGAT2α多肽产物的核酸组合物，以及由此编码的哺乳动物DGAT2α多肽产物及其制备方法。 主题DGAT2α多肽和核酸组合物可用于各种应用，包括研究，诊断和治疗剂筛选应用，以及治疗疗法和三酰基甘油的生产。

公开(公告)号：US07045326B2

公开(公告)日：2006-05-16

申请号：US10046924

申请日：2002-01-14

申请人： Sylvaine Cases ,  Scot J. Stone ,  Ping Zhou ,  Robert V. Farese, Jr. ,  Chi-Liang Eric Yen

发明人： Sylvaine Cases ,  Scot J. Stone ,  Ping Zhou ,  Robert V. Farese, Jr. ,  Chi-Liang Eric Yen

IPC分类号： C12N9/10 ,  C07H21/04

CPC分类号： C12N9/1029 ,  A01K2217/05 ,  A61K38/00 ,  A61K2039/505 ,  C12Y203/0102 ,  C12Y203/01022

摘要： Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase and/or monoacylglycerol acyltransferase activity, as well as the polypeptide products encoded thereby, i.e., mammalian DGAT2α and MGAT1 polypeptide products, and methods for producing the same, are provided. Also provided are: methods and compositions for modulating DGAT2α and MGAT1 activity; DGAT2α and MGAT1 transgenic cells, animals and plants, as well as methods for their preparation; and methods for making diglyceride, diglyceride compositions, triglycerides and triglyceride compositions, as well as the compositions produced by these methods. The subject methods and compositions find use in a variety of different applications, including research, medicine, agriculture and industry applications.

摘要翻译： 提供了编码具有甘油二酯酰基转移酶和/或单酰基甘油酰基转移酶活性的多肽产物的核酸组合物，以及由此编码的多肽产物，即哺乳动物DGAT2α和MGAT1多肽产物及其制备方法。 还提供了：用于调节DGAT2alpha和MGAT1活性的方法和组合物; DGAT2alpha和MGAT1转基因细胞，动物和植物，以及它们的制备方法; 以及制备甘油二酯，甘油二酯组合物，甘油三酯和甘油三酯组合物的方法以及通过这些方法制备的组合物。 主题方法和组合物可用于各种不同的应用，包括研究，医学，农业和工业应用。