公开(公告)号：US20140072615A1

公开(公告)日：2014-03-13

申请号：US14080948

申请日：2013-11-15

申请人： Te-Yen CHIEN

发明人： Te-Yen CHIEN

IPC分类号： A61K9/70 ,  A61K31/57

CPC分类号： A61K9/7038 ,  A61K9/0014 ,  A61K9/7061 ,  A61K31/565 ,  A61K31/57 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K2300/00

摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.

摘要翻译： 公开透皮激素释放系统（THDS）。 THDS可用于控制生育力，并用于通过强力递送孕激素和雌激素激素，特别是孕激素左炔诺孕酮治疗的各种疾病和病症。 THDS包括背衬层，邻接的粘合剂聚合物基质，其包含有效量的至少一种孕激素，其输送通过以预定量存在的一种或多种皮肤渗透增强剂增强。 THDS能够从与皮肤接触的小表面积（例如小于20平方厘米）提供孕激素和雌激素的有效日剂量。 还公开了生育控制方法和利用THDS的各种类型的激素替代疗法。

公开(公告)号：US08221784B2

公开(公告)日：2012-07-17

申请号：US12543859

申请日：2009-08-19

申请人： Te-Yen Chien

发明人： Te-Yen Chien

IPC分类号： A61F13/02 ,  A61F13/00 ,  A61L15/16 ,  A61K9/70

CPC分类号： A61K9/7038 ,  A61K9/0014 ,  A61K9/7061 ,  A61K31/565 ,  A61K31/57 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K2300/00

摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.

公开(公告)号：US4818540A

公开(公告)日：1989-04-04

申请号：US902440

申请日：1986-08-29

申请人： Yie W. Chien ,  Te-Yen Chien ,  Yih-Chain Huang

发明人： Yie W. Chien ,  Te-Yen Chien ,  Yih-Chain Huang

IPC分类号： A61K9/70 ,  A61K31/565 ,  A61K31/57 ,  A61F13/00

CPC分类号： A61K9/7069 ,  A61K9/7084

摘要： Transdermal fertility-controlling absorption polymer matrix dosage units have been developed which comprise a backing layer, an adjoining layer of a solid polymer matrix in which minimum effective daily doses of an estrogen and a progestin are microdispersed and released for transdermal absorption. Presently preferred is use of the natural estrogen, 17-beta-estradiol, and of the progestin, levonorgestrel. The units have a biologically acceptable adhesive polymer layer. The polymer matrix as well as the adhesive layer can have dispersed one or more skin permeation enhancers. Dosage units are provided which transdermally deliver at least minimum daily doses of the estrogen and progestin for multiple days, such as for one week. The invention also provides a process of fertility control using the novel polymer matrix dosage units for the first three weeks of consecutive menstrual cycles of the subject desiring fertility control.

摘要翻译： 已经开发了经皮生育控制吸收聚合物基质剂量单位，其包含背衬层，固体聚合物基质的相邻层，其中雌激素和孕激素的最小有效日剂量被微分散并释放用于经皮吸收。 目前优选使用天然雌激素17-β-雌二醇和孕激素左炔诺孕酮。 这些单元具有生物可接受的粘合剂聚合物层。 聚合物基质以及粘合剂层可以分散一种或多种皮肤渗透促进剂。 提供剂量单位，其经皮递送至少最小日剂量的雌激素和孕激素多天，例如一周。 本发明还提供了一种使用新型聚合物基质剂量单位进行育性控制的方法，该方法用于需要生育控制的受试者的连续月经周期的前三周。

公开(公告)号：US20150037395A1

公开(公告)日：2015-02-05

申请号：US14519758

申请日：2014-10-21

申请人： Te-Yen CHIEN

发明人： Te-Yen CHIEN

IPC分类号： A61K9/70 ,  A61K31/57

CPC分类号： A61K9/7038 ,  A61K9/0014 ,  A61K9/7061 ,  A61K31/565 ,  A61K31/57 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K2300/00

摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.

摘要翻译： 公开透皮激素释放系统（THDS）。 THDS可用于控制生育力，并用于通过强力递送孕激素和雌激素激素，特别是孕激素左炔诺孕酮治疗的各种疾病和病症。 THDS包括背衬层，邻接的粘合剂聚合物基质，其包含有效量的至少一种孕激素，其输送通过以预定量存在的一种或多种皮肤渗透增强剂增强。 THDS能够从与皮肤接触的小表面积（例如小于20平方厘米）提供孕激素和雌激素的有效日剂量。 还公开了生育控制方法和利用THDS的各种类型的激素替代疗法。

公开(公告)号：US08221785B2

公开(公告)日：2012-07-17

申请号：US12556740

申请日：2009-09-10

申请人： Te-Yen Chien

发明人： Te-Yen Chien

IPC分类号： A61F13/02 ,  A61F13/00 ,  A61L15/16 ,  A61K9/70

CPC分类号： A61K9/7038 ,  A61K9/0014 ,  A61K9/7061 ,  A61K31/565 ,  A61K31/57 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K2300/00

摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.

摘要翻译： 公开透皮激素释放系统（THDS）。 THDS可用于控制生育力，并用于通过强力递送孕激素和雌激素激素，特别是孕激素左炔诺孕酮治疗的各种疾病和病症。 THDS包括背衬层，邻接的粘合剂聚合物基质，其包含有效量的至少一种孕激素，其输送通过以预定量存在的一种或多种皮肤渗透增强剂增强。 THDS能够从与皮肤接触的小表面积（例如小于20平方厘米）提供孕激素和雌激素的有效日剂量。 还公开了生育控制方法和利用THDS的各种类型的激素替代疗法。

公开(公告)号：US5762956A

公开(公告)日：1998-06-09

申请号：US638009

申请日：1996-04-24

申请人： Yie W. Chien ,  Te-Yen Chien ,  Sai-Jun Gong

发明人： Yie W. Chien ,  Te-Yen Chien ,  Sai-Jun Gong

IPC分类号： A61K9/70 ,  A61K31/565 ,  A61K31/57 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61F13/00

CPC分类号： A61K9/7061 ,  A61K31/565 ,  A61K31/57 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  Y10S514/946 ,  Y10S514/947

摘要： A transdermal contraceptive delivery system (TCDS) for fertility control in women is described comprising a backing layer, an adjoining layer of a solid absorption adhesive polymer matrix in which minimum effective daily doses of an estrogen and a progestin are dispersed and released for transdermal absorption. Presently preferred is use of the natural estrogen, 17-beta-estradiol, and the synthetic progestin, levonorgestrel. Along with these two steroidal contraceptive agents, a combination of several chemical skin permeation enhancing agents, blended at specific weight ratios, are homogeneously dispersed in the adhesive polymer matrix. The invention also provides a process of fertility control utilizing the transdermal contraceptive delivery system.

摘要翻译： 描述了一种用于妇女生育控制的透皮避孕药递送系统（TCDS），其包括背层，固体吸收性粘合剂聚合物基质的邻接层，其中分散和释放雌激素和孕激素的最小有效日剂量用于经皮吸收。 目前优选使用天然雌激素，17-β-雌二醇和合成孕激素左炔诺孕酮。 与这两种甾体避孕剂一起，以特定重量比共混的几种化学皮肤渗透增强剂的组合均匀地分散在粘合剂聚合物基质中。 本发明还提供利用透皮避孕药递送系统的生殖调控过程。

公开(公告)号：US20090311312A1

公开(公告)日：2009-12-17

申请号：US12543859

申请日：2009-08-19

申请人： Te-Yen Chien

发明人： Te-Yen Chien

IPC分类号： A61K9/70 ,  A61K31/57

CPC分类号： A61K9/7038 ,  A61K9/0014 ,  A61K9/7061 ,  A61K31/565 ,  A61K31/57 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K2300/00

摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.

摘要翻译： 公开透皮激素释放系统（THDS）。 THDS可用于控制生育力，并用于通过强力递送孕激素和雌激素激素，特别是孕激素左炔诺孕酮治疗的各种疾病和病症。 THDS包括背衬层，邻接的粘合剂聚合物基质，其包含有效量的至少一种孕激素，其输送通过以预定量存在的一种或多种皮肤渗透增强剂增强。 THDS能够从与皮肤接触的小表面积（例如小于20平方厘米）提供孕激素和雌激素的有效日剂量。 还公开了生育控制方法和利用THDS的各种类型的激素替代疗法。

公开(公告)号：US07384650B2

公开(公告)日：2008-06-10

申请号：US10621711

申请日：2003-07-17

申请人： Te-Yen Chien

发明人： Te-Yen Chien

IPC分类号： A61F13/02 ,  A61L15/16

CPC分类号： A61K9/7038 ,  A61K9/0014 ,  A61K9/7061 ,  A61K31/565 ,  A61K31/57 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K2300/00

摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.

摘要翻译： 公开透皮激素释放系统（THDS）。 THDS可用于控制生育力，并用于通过强力递送孕激素和雌激素激素，特别是孕激素左炔诺孕酮治疗的各种疾病和病症。 THDS包括背衬层，邻接的粘合剂聚合物基质，其包含有效量的至少一种孕激素，其输送通过以预定量存在的一种或多种皮肤渗透增强剂增强。 THDS能够从与皮肤接触的小表面积（例如小于20平方厘米）提供孕激素和雌激素的有效日剂量。 还公开了生育控制方法和利用THDS的各种类型的激素替代疗法。

公开(公告)号：US5788983A

公开(公告)日：1998-08-04

申请号：US943169

申请日：1992-09-14

申请人： Yie W. Chien ,  Guo-Shen Chen ,  Te-Yen Chien

发明人： Yie W. Chien ,  Guo-Shen Chen ,  Te-Yen Chien

IPC分类号： A61K9/70 ,  A61F13/02

CPC分类号： A61K9/7084 ,  A61K9/7092

摘要： Transdermal polymer dosage units are provided which comprise a backing layer and a reservoir layer. The reservoir layer can have multiple regions which contact the skin during use, optionally may have different pharmaceuticals, may provide variable rate of transdermal absorption, and may provide the pharmaceuticals in the form of microreservoirs or one or more macroreservoirs. The reservoir region can comprise a macroreservoir of one or more pharmaceuticals wherein the reservoir is bounded by a backing layer and a layer of a substantially non-porous permeability-regulating polymer membrane which directly or indirectly contacts the skin during transdermal administration. Also, provided is a process of transdermal administration of pharmaceuticals using the novel dosage units.

摘要翻译： 提供透皮聚合物剂量单位，其包含背衬层和储存层。 储存层可以具有在使用期间接触皮肤的多个区域，任选地可以具有不同的药物，可以提供可变的经皮吸收速率，并且可以以微储存器或一个或多个宏储存器的形式提供药物。 储存器区域可以包括一种或多种药物的大容量储存器，其中储存器由透皮给药期间直接或间接接触皮肤的背衬层和基本上无孔的渗透性调节聚合物膜层限制。 此外，提供了使用新型剂量单位透皮给药药物的方法。

公开(公告)号：US5023084A

公开(公告)日：1991-06-11

申请号：US285878

申请日：1988-12-16

申请人： Yie W. Chien ,  Te-Yen Chien

发明人： Yie W. Chien ,  Te-Yen Chien

IPC分类号： A23G1/00 ,  A23G1/56 ,  A23G3/34 ,  A23J3/32 ,  A23J3/34 ,  A23K1/16 ,  A23K1/18 ,  A61F13/00 ,  A61F13/02 ,  A61K20060101 ,  A61K9/70 ,  A61K31/56 ,  A61K31/565 ,  A61K31/57 ,  A61K38/01

CPC分类号： A23J3/32 ,  A23G1/56 ,  A23G3/346 ,  A23J3/341 ,  A23J3/346 ,  A23K20/147 ,  A23K50/30 ,  A61F13/023 ,  A61F13/0253 ,  A61K31/565 ,  A61K31/567 ,  A61K38/011 ,  A61K38/012 ,  A61K9/7061 ,  A61K9/7069 ,  A61K9/7092 ,  A23V2002/00 ,  A61F2013/00544 ,  A61F2013/00906 ,  A61F2013/00927

摘要： Transdermal estrogen/progestin adsorption dosage units have been developed which comprise a backing layer, an adjoining polymer layer is an adhesive layer in which at least minimum effective dose of an estrogen is dissolved or microdispersed. Adhered to the polymer layer is an adhesive layer in which is dissolved and/or microdispersed at least minimum doses of progestin. Presently preferred is use of the natural estrogen, 17-beta-estradiol, or ethinyl estradiol or combinations thereof and of the progestin. The units have biologically acceptable adhesive and polymer layers. The adhesive layer can have dispersed one or more skin permeation enhancing agents. A separating layer can optionally be used in making the dosage units, which separate the adhesive and polymer layers, which permits estrogen transmission from the polymer layer during treatment. Dosage units are provided which transdermally deliver at least minimum daily doses of the estrogen and progestin for multiple days, such as for one week. The invention also provides a process for fertility control and estrogen replacement therapy using the novel dosage units. Also, the invention provides a fertility control system for fertility control using the novel dosage units.

摘要翻译： 已经开发了经皮雌激素/孕激素吸收剂量单位，其包含背衬层，相邻的聚合物层是其中至少最小有效剂量的雌激素溶解或微分散的粘合剂层。 粘附到聚合物层是粘合剂层，其中溶解和/或微分散至少最小剂量的孕激素。 目前优选使用天然雌激素，17-β-雌二醇或乙炔雌二醇或其组合和孕激素。 这些单元具有生物可接受的粘合剂和聚合物层。 粘合剂层可以具有分散的一种或多种皮肤渗透增强剂。 分离层可以任选地用于制备分离粘合剂和聚合物层的剂量单位，其允许在治疗期间从聚合物层传递雌激素。 提供剂量单位，其经皮递送至少最小日剂量的雌激素和孕激素多天，例如一周。 本发明还提供了使用新型剂量单位的生育调节和雌激素替代疗法的方法。 此外，本发明提供了使用新型剂量单位的育性控制的育性控制系统。