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公开(公告)号:US20230081694A1
公开(公告)日:2023-03-16
申请号:US17796221
申请日:2021-01-29
摘要: Disclosed herein are articles and methods for blood separation. For example, inventive articles and methods that remove red blood cells from blood samples are described.
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公开(公告)号:US11576862B2
公开(公告)日:2023-02-14
申请号:US15646601
申请日:2017-07-11
发明人: David L. Kaplan , Tuna Yucel , Xiaoqin Wang , Michael Lovett
摘要: Provided herein relates to methods and compositions for preparing a silk microsphere and the resulting silk microsphere. In some embodiments, the methods and compositions described herein are all aqueous, which can be used for encapsulating an active agent in a silk microsphere, while maintaining activity of the active agent during processing. In some embodiments, the resulting silk microsphere can be used for sustained delivery of an active agent encapsulated therein.
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公开(公告)号:US20220370647A1
公开(公告)日:2022-11-24
申请号:US17211481
申请日:2021-03-24
发明人: William W. Bachovchin , Hung-sen Lai , Wengen Wu
IPC分类号: A61K51/04
摘要: The tumor stroma, which accounts for a large part of the tumor mass, represents an attractive target for the delivery of diagnostic and therapeutic compounds. Here, the focus is notably on a subpopulation of stromal cells, known as cancer-associated fibroblasts, which are present in more than 90% of epithelial carcinomas, including pancreatic, colon, and breast cancer. Cancer-associated fibroblasts feature high expression of FAP, which is not detectable in adult normal tissue but is associated with a poor prognosis in cancer patients. The present invention provides small-molecule radiopharmaceutical and imaging agents based on a FAP-specific inhibitor.
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公开(公告)号:US20220306922A1
公开(公告)日:2022-09-29
申请号:US17596896
申请日:2020-06-19
IPC分类号: C09J189/00
摘要: An adhesive composition and methods of making and using the same are disclosed. The composition includes a polymeric component and a metal cation or an oxidant. The polymeric component includes a silk fibroin protein and a catecholamine. The metal cation and/or the oxidant is present in an amount sufficient to initiate complexing and/or cross-linking of the adhesive composition.
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公开(公告)号:US20220299494A1
公开(公告)日:2022-09-22
申请号:US17753312
申请日:2020-08-28
发明人: David L. Kaplan , Qiaobing Xu
摘要: The present disclosure provides a method for screening drug delivery vehicles for use in delivering cargo via oral delivery. The method includes introducing a drug delivery vehicle comprising an imaging agent into a lumen of an artificial intestine system composed of a scaffold matrix material. The scaffold matrix material includes an interconnected network of pores, intestinal epithelial cells positioned on an inner surface of the lumen, and human-based cells positioned within the pores and surrounding the intestinal epithelial cells. The method includes maintaining the artificial intestine system in physiologically relevant conditions for a predetermined length of time, and detecting a color change induced by the imaging agent within at least a portion of the human-based cells.
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公开(公告)号:US11447753B2
公开(公告)日:2022-09-20
申请号:US16868243
申请日:2020-05-06
申请人: Northwestern University , Board of Regents of the University of Nebraska , Trustees of Tufts College (AKA Tufts University)
IPC分类号: A61K39/245 , A61K39/25 , C12N7/00 , C07K14/005 , A61K39/12 , A61K35/763 , A61K39/00
摘要: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
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公开(公告)号:US20220283113A1
公开(公告)日:2022-09-08
申请号:US17545151
申请日:2021-12-08
发明人: Sameer Sonkusale , Junfei Xia , Francois Dufay
IPC分类号: G01N27/409 , G01N27/406 , G01N27/407
摘要: An oxygen sensor for sensing dissolved oxygen concentration in tissue includes an electrochemical sensor comprising first and second conductive threads having proximal sections connected to a potentiostat. The first thread forms a cathode, and the second thread forms an anode.
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公开(公告)号:US20220218267A1
公开(公告)日:2022-07-14
申请号:US17617654
申请日:2020-06-12
发明人: Sergio Fantini , Angelo Sassaroli , Giles Blaney
摘要: An apparatus for earning out near-infrared spectroscopy using intensity-modulated near-infrared radiation or pulsed near-infrared radiation includes sources and detectors. For each source, there exists first and second distances. The first distance is a distance between the source and a first detector. The second distance is a distance between the source and the second detector. For each source, the difference between these two distances is the same. Additionally, wherein, for each source, the detector at a shorter distance is the same detector that is at a longer distance for the other source. A processor derives, from signals received by the detectors, a parameter indicative of two matched slopes. Tins parameter is either phase of the intensity-modulated near-infrared radiation or mean time-of-flight data for the pulsed near-infrared radiation. The processor then provides output data based on an average of the matched slopes. This promotes reduced sensitivity to superficial layers and enhanced sensitivity to deeper portions of a medium that is under investigation.
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公开(公告)号:US11386507B2
公开(公告)日:2022-07-12
申请号:US16579454
申请日:2019-09-23
申请人: International Business Machines Corporation , TRUSTEES OF TUFTS COLLEGE , Ramot at Tel-Aviv University Ltd.
发明人: Lior Horesh , Osman Asif Malik , Shashanka Ubaru , Misha E. Kilmer , Haim Avron
IPC分类号: G06Q50/00 , G06F17/16 , G06N20/00 , G06F16/901
摘要: A computer-implemented method for analyzing a time-varying graph is provided. The time-varying graph includes nodes representing elements in a network, edges representing transactions between elements, and data associated with the nodes and the edges. The computer-implemented method includes constructing, using a processor, adjacency and feature matrices describing each node and edge of each time-varying graph for stacking into an adjacency tensor and describing the data of each time-varying graph for stacking into a feature tensor, respectively. The adjacency and feature tensors are partitioned into adjacency and feature training tensors and into adjacency and feature validation tensors, respectively. An embedding model and a prediction model are created using the adjacency and feature training tensors. The embedding and prediction models are validated using the adjacency and feature validation tensors to identify an optimized embedding-prediction model pair.
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公开(公告)号:US20220211883A1
公开(公告)日:2022-07-07
申请号:US17554823
申请日:2021-12-17
发明人: William W. Bachovchin , Hung-sen Lai , Wengen Wu
IPC分类号: A61K51/04
摘要: The present disclosure relates to fibroblast-activation protein (FAP)-activated theranostic prodrugs, pharmaceutical compositions comprising them, and methods of treating a disorder characterized by FAP upregulation, such as cancer.
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