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公开(公告)号：US20210154661A1
公开(公告)日：2021-05-27
申请号：US16625993
申请日：2018-06-29
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , UNIVERSITE PARIS DESCARTES - PARIS V , SORBONNE UNIVERSITE , UNIVERSITE PARIS DIDEROT-PARIS 7
发明人： Jean-Luc AIDER , Mauricio HOYOS , Gabriel DUMY
摘要： A method is provided for manipulating objects in a cavity including a liquid, the method including providing in at least one region of the cavity objects capable of absorbing light in a given wavelength range, forming an aggregate of the objects by submitting them to an acoustic field, and disrupting the aggregate by submitting the aggregate to a light beam emitting at the given wavelength range. Also provided is a device for manipulating objects.
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公开(公告)号：US09521839B2
公开(公告)日：2016-12-20
申请号：US14372971
申请日：2013-01-17
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE PARIS DESCARTES (PARIS V) , UNIVERSITE DE VERSAILLES—SAINT QUENTIN EN YVELINES
发明人： Anne Pelle Meddahi , Aicha Abed , Didier Letourneur , Anne Baudot
IPC分类号： A01N1/02
CPC分类号： A01N1/0231 , A01N1/0221 , A01N1/0284
摘要： The present invention provides a method for cryoprotecting a biological specimen comprising the step of freezing said biological specimen in the presence of a hydrogel and in the absence of cryoprotectant.
摘要翻译： 本发明提供了一种用于冷冻保护生物样品的方法，包括在水凝胶存在下和没有冷冻保护剂的情况下冷冻所述生物样品的步骤。
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公开(公告)号：US20150087056A1
公开(公告)日：2015-03-26
申请号：US14372971
申请日：2013-01-17
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE PARIS DESCARTES (PARIS V) , UNIVERSITE DE VERSAILLES - SAINT QUENTIN EN YVELINES
发明人： Anne Pelle Meddahi , Aicha Abed , Didier Letourneur , Anne Baudot
IPC分类号： A01N1/02
CPC分类号： A01N1/0231 , A01N1/0221 , A01N1/0284
摘要： The present invention provides a method for cryoprotecting a biological specimen comprising the step of freezing said biological specimen in the presence of a hydrogel and in the absence of cryoprotectant.
摘要翻译： 本发明提供了一种用于冷冻保护生物样品的方法，包括在水凝胶存在下和没有冷冻保护剂的情况下冷冻所述生物样品的步骤。
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公开(公告)号：US09377471B2
公开(公告)日：2016-06-28
申请号：US14547208
申请日：2014-11-19
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Universite Paris Descartes—Paris V , Assistance Publique—Hopitaux de Paris , Fondation Imagine
CPC分类号： C07K16/18 , A61K31/70 , A61K31/7088 , A61K38/02 , G01N33/5094 , G01N33/6893 , G01N33/80 , G01N2333/805 , G01N2500/02 , G01N2800/22
摘要： Methods and compositions for the treatment of β-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with β-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 α-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.
摘要翻译： 提供了治疗“地中海贫血”的方法和组合物。 方法和组合物通过预防GATA-1蛋白的蛋白水解来恢复或增加患有'bgr-TM'的个体的红细胞成熟。 用于鉴定结合热休克蛋白70（HSP-70）并抑制HSP-70α-珠蛋白结合但允许以防止GATA-1蛋白水解的方式进行GATA-1蛋白-HSP-1结合的试剂的筛选方法。
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公开(公告)号：US20150297628A1
公开(公告)日：2015-10-22
申请号：US14749758
申请日：2015-06-25
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE PARIS DESCARTES (PARIS V) , UNIVERSITE PARIS SUD - PARIS XI
发明人： Alain TEDGUI , Xavier LOYER , Jean MACCARIO
IPC分类号： A61K31/713 , C12Q1/68 , A61K31/7105
CPC分类号： A61K31/713 , A61K31/7105 , C12N15/113 , C12Q1/6883 , C12Q2600/106 , C12Q2600/16 , C12Q2600/178
摘要： The present invention relates to the treatment and the diagnosis of atherosclerosis, in particular to a miRNA for use in the treatment and the diagnosis of atherosclerosis.
摘要翻译： 本发明涉及动脉粥样硬化的治疗和诊断，特别涉及用于治疗和诊断动脉粥样硬化的miRNA。
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公开(公告)号：US20150141341A1
公开(公告)日：2015-05-21
申请号：US14547208
申请日：2014-11-19
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Universite Paris Descartes - Paris V , Assistance Publique - Hopitaux de Paris , Fondation Imagine
CPC分类号： C07K16/18 , A61K31/70 , A61K31/7088 , A61K38/02 , G01N33/5094 , G01N33/6893 , G01N33/80 , G01N2333/805 , G01N2500/02 , G01N2800/22
摘要： Methods and compositions for the treatment of β-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with β-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 α-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.
摘要翻译： 提供了治疗“地中海贫血”的方法和组合物。 方法和组合物通过预防GATA-1蛋白的蛋白水解来恢复或增加患有'bgr-TM'的个体的红细胞成熟。 用于鉴定结合热休克蛋白70（HSP-70）并抑制HSP-70α-珠蛋白结合但是以防止GATA-1蛋白水解的方式允许GATA-1蛋白-HSP-1结合的试剂的筛选方法。
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公开(公告)号：US20160368975A1
公开(公告)日：2016-12-22
申请号：US15161603
申请日：2016-05-23
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Universite Paris Descartes - Paris V , Assistance Publique - Hopitaux de Paris , Fondation Imagine
CPC分类号： C07K16/18 , A61K31/70 , A61K31/7088 , A61K38/02 , G01N33/5094 , G01N33/6893 , G01N33/80 , G01N2333/805 , G01N2500/02 , G01N2800/22
摘要： Methods and compositions for the treatment of β-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with β-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 α-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.
摘要翻译： 提供了治疗β-地中海贫血的方法和组合物。 方法和组合物通过预防GATA-1蛋白的蛋白水解来恢复或增加患有β-TM的个体的红细胞成熟。 用于鉴定结合热休克蛋白70（HSP-70）并抑制HSP-70α-珠蛋白结合但允许以防止GATA-1蛋白水解的方式进行GATA-1蛋白-HSP-1结合的试剂的筛选方法。
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