利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

1099 条记录 (耗时 0.025 秒)

    System and method for detecting a periprosthetic infection
    4.
    发明授权
    System and method for detecting a periprosthetic infection 有权

    公开(公告)号：US11898961B2

    公开(公告)日：2024-02-13

    申请号：US16838253

    申请日：2020-04-02

    申请人： ALIO, Inc.

    发明人： Forrest Miller ,  Samit Kumar Gupta ,  David John Kuraguntla ,  Elsa Swanson

    IPC分类号： G01N33/50 ,  G01N21/51 ,  G01N21/84 ,  G01N33/543

    CPC分类号： G01N21/8483 ,  G01N21/51 ,  G01N33/5094 ,  G01N2333/4737 ,  G01N2333/914 ,  G01N2800/26

    摘要： A system, device and method for measuring markers for a periprosthetic joint infection in a sample of synovial fluid. A sensor reader device includes a vial receptacle for receiving a vial containing synovial fluid. A light source illuminates the vial and an optical sensor detects light scattered and/or absorbed by white blood cells in the fluid sample. An electrical signal corresponding to the intensity of the light received at the optical sensor is detected. A white blood cell concentration is determined from the electrical signal value. The sensor reader device also includes one or more immunoassay strip receptacles. Immunoassay strips for other marker are inserted into the receptacles. Immunoassay optical sensors detect light generated by the immunoassay reaction on the immunoassay strip to determine the concentration of the marker. In example implementations, the device includes an immunoassay strip reader for leukocyte esterase and c-reactive protein.

    Diabetes Biomarkers
    9.
    发明公开
    Diabetes Biomarkers 审中-公开

    公开(公告)号：US20230333094A1

    公开(公告)日：2023-10-19

    申请号：US18140214

    申请日：2023-04-27

    申请人： Phaim Pharma Ltd.

    发明人： Tihamer ORBAN

    IPC分类号： G01N33/50 ,  G01N33/564 ,  G01N33/569

    CPC分类号： G01N33/5094 ,  G01N33/564 ,  G01N33/56972 ,  G01N2800/042 ,  G01N2800/52

    摘要： A new markers for insulin production decline in Type 1 diabetes has been found in the ratio the CD4 naïve (CD45RO−CD62L+) to central memory (CD45RO+CD62L+) and in the level of CD4 central memory T-cell subpopulations. A method of diagnosing autoimmunity and its progressiveness, more specifically diabetes, pre-diabetes, a susceptibility to diabetes mellitus, or the level of effectiveness of therapy/intervention modality for one or more of such conditions in a subject can be conducted by determining level of CD4 naïve (CD45RO−CD62L+) T-cells by immunofluorescence analysis of a sample extracted from a subject; determining level of CD4 central memory (CD45RO+CD62L+) T-cells by immunofluorescence analysis of a sample extracted from a subject, and quantitatively relating the levels of the CD4 naïve and central memory T-cells, wherein a low ratio of CD4 naïve T-cells to CD4 central memory T-cells and/or high CD4 central memory T-cell indicates autoimmunity, a susceptibility to autoimmunity, diabetes, pre-diabetes, a susceptibility to diabetes mellitus or ineffectiveness of a treatment for one or more of such conditions.

    SAMPLE ANALYZER AND PLATELET COUNTING METHOD
    10.
    发明公开
    SAMPLE ANALYZER AND PLATELET COUNTING METHOD 审中-公开

    公开(公告)号：US20230333093A1

    公开(公告)日：2023-10-19

    申请号：US18134862

    申请日：2023-04-14

    申请人： Shenzhen Mindray Bio-Medical Electronics Co., Ltd.

    发明人： Wenbo ZHENG ,  Bo YE ,  Donglan YAO ,  Huan QI ,  Yi YE

    IPC分类号： G01N33/50 ,  G01N15/14 ,  G01N33/49

    CPC分类号： G01N33/5094 ,  G01N15/1459 ,  G01N33/49 ,  G01N15/1425 ,  G01N2015/0084

    摘要： A sample analyzer includes a sample preparation device, an impedance testing device, an optical testing device, and a controller. The controller is configured to control the impedance testing device to test a first test sample to obtain a first platelet counting result for a test blood sample based on electronic information of the first test sample; control the optical testing device to test a second test sample to obtain a second platelet counting result for the test blood sample based only on optical information of the second test sample or based on both the electronic information of the first test sample and the optical information of the second test sample; determine whether the first platelet counting result is unreliable due to abnormality of the test blood sample; and output the first and/or the second platelet counting result according to the result of the determination.