公开(公告)号：US08089244B2

公开(公告)日：2012-01-03

申请号：US12481689

申请日：2009-06-10

申请人： Wei-Ming Zhang ,  Jun Lu ,  Jin Li

发明人： Wei-Ming Zhang ,  Jun Lu ,  Jin Li

IPC分类号： H02J7/00 ,  H02J7/02 ,  H01R13/44

CPC分类号： H01R24/68 ,  H01R2103/00

摘要： An electronic device includes a main body, at least two pins folded mounted to the main body, and at least two conductive assemblies received in the main body. Each of the conductive assemblies includes a locking member and a resilient member resisting the locking member, when the pins are pushed and substantially perpendicular to main body, each locking member is capable of locking with an end of one of the pins.

摘要翻译： 电子设备包括主体，至少两个折叠安装到主体的销以及容纳在主体中的至少两个导电组件。 每个导电组件包括锁定构件和抵抗锁定构件的弹性构件，当销被推动并且基本上垂直于主体时，每个锁定构件能够与其中一个销的端部锁定。

公开(公告)号：US20100148722A1

公开(公告)日：2010-06-17

申请号：US12481689

申请日：2009-06-10

申请人： WEI-MING ZHANG ,  JUN LU ,  JIN LI

发明人： WEI-MING ZHANG ,  JUN LU ,  JIN LI

IPC分类号： H02J7/00

CPC分类号： H01R24/68 ,  H01R2103/00

摘要： An electronic device includes a main body, at least two pins folded mounted to the main body, and at least two conductive assemblies received in the main body. Each of the conductive assemblies includes a locking member and a resilient member resisting the locking member, when the pins are pushed and substantially perpendicular to main body, each locking member is capable of locking with an end of one of the pins.

摘要翻译： 电子设备包括主体，至少两个折叠安装到主体的销以及容纳在主体中的至少两个导电组件。 每个导电组件包括锁定构件和抵抗锁定构件的弹性构件，当销被推动并且基本上垂直于主体时，每个锁定构件能够与其中一个销的端部锁定。

公开(公告)号：US07112337B2

公开(公告)日：2006-09-26

申请号：US10020671

申请日：2001-12-12

申请人： Shi-Kun Huang ,  Samuel Zalipsky ,  Wei-Ming Zhang

发明人： Shi-Kun Huang ,  Samuel Zalipsky ,  Wei-Ming Zhang

IPC分类号： A61K9/127

CPC分类号： A61K9/1272 ,  A61K47/542 ,  A61K47/543 ,  A61K47/544 ,  A61K47/551 ,  A61K47/554 ,  A61K47/60 ,  A61K47/6911 ,  A61K48/00 ,  C07D233/64 ,  C12N15/88

摘要： A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a dithiobenzyl linkage. The liposomes are associated with a nucleic acid for delivery to a cell.

摘要翻译： 描述了用于体内或离体递送核酸的脂质体组合物。 组合物中的脂质体包括（i）在生理pH下负责中性的脂质，并且在pH值小于生理pH下带正电荷的脂质，和（ii）通过二硫代苄基键连接到亲水性聚合物的脂质。 脂质体与用于递送至细胞的核酸相关联。

公开(公告)号：US20050260261A1

公开(公告)日：2005-11-24

申请号：US11133879

申请日：2005-05-19

申请人： Shi Huang ,  Samuel Zalipsky ,  Wei-Ming Zhang ,  Bei Jin ,  Yolanda Quinn

发明人： Shi Huang ,  Samuel Zalipsky ,  Wei-Ming Zhang ,  Bei Jin ,  Yolanda Quinn

IPC分类号： C07D233/02 ,  A61K9/127 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/22 ,  A61K47/44 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54

CPC分类号： A61K9/1271 ,  A61K9/1272 ,  A61K47/542 ,  A61K47/543 ,  A61K48/00 ,  C07D233/54 ,  C07D233/64 ,  Y10T428/2984

摘要： A lipid represented by the formula: wherein each of R1 and R2 is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0-20; L is selected from the group consisting of (i) —X—(C═O)—Y—, (ii) —X—(C═O)—, and (iii) —X—CH2—, wherein X and Y are independently selected from oxygen, NH and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0 is described.

摘要翻译： 由下式表示的脂质：其中R 1和R 2各自为具有约8至约24个碳原子的烷基或链烯基链; n = 0-20; L选自（i）-X-（CO）-Y-，（ii）-X-（CO） - 和（iii）-X-CH 2 - 其中X和Y独立地选自氧，NH和直接键; 并且Z是具有小于约7.4且大于约4.0的pK的弱碱性部分。

公开(公告)号：US06974589B1

公开(公告)日：2005-12-13

申请号：US09685940

申请日：2000-10-10

申请人： Shi Kun Huang ,  Samuel Zalipsky ,  Wei-Ming Zhang ,  Bei Jin ,  Yolanda P. Quinn

发明人： Shi Kun Huang ,  Samuel Zalipsky ,  Wei-Ming Zhang ,  Bei Jin ,  Yolanda P. Quinn

IPC分类号： C07D233/02 ,  A61K9/127 ,  A61K31/7105 ,  A61K31/711 ,  A61K47/22 ,  A61K47/44 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C07D233/54

CPC分类号： A61K9/1271 ,  A61K9/1272 ,  A61K47/542 ,  A61K47/543 ,  A61K48/00 ,  C07D233/54 ,  C07D233/64 ,  Y10T428/2984

摘要： A lipid represented by the formula: wherein each of R1 and R2 is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0–20; L is selected from the group consisting of (i) —X—(C═O)—Y—, (ii) —X—(C═O)—, and (iii) —X—CH2—, wherein X and Y are independently selected from oxygen, NH, and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0 is described.

摘要翻译： 由下式表示的脂质：其中R 1和R 2各自为具有约8至约24个碳原子的烷基或链烯基链; n = 0-20; L选自（i）-X-（CO）-Y-，（ii）-X-（CO） - 和（iii）-X-CH 2 - 其中X和Y独立地选自氧，NH和直接键; 并且Z是具有小于约7.4且大于约4.0的pK的弱碱性部分。