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    Therapeutic liposome composition and method
    5.
    发明授权
    Therapeutic liposome composition and method 有权

    公开(公告)号：US06660525B2

    公开(公告)日：2003-12-09

    申请号：US09501857

    申请日：2000-02-10

    申请人： Francis J. Martin ,  Samuel Zalipsky ,  Shi Kun Huang

    发明人： Francis J. Martin ,  Samuel Zalipsky ,  Shi Kun Huang

    IPC分类号： C12N1586

    CPC分类号： A61K9/1273 ,  A61K9/1271

    摘要： A method of liposome-based therapy for a mammalian subject is disclosed. The method uses liposomes with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic polymer coating effective to shield the affinity moiety from interaction with the target surface. The hydrophilic polymer coating is made up of polymer chains covalently linked to surface lipid components in the liposomes through releasable linkages. After a desired liposome biodistribution is achieved, a releasing agent is administered to cause cleaving of a substantial portion of the releasable linkages in the liposomes, to expose the affinity agent to the target surface.

    Therapeutic liposome composition and method
    7.
    发明授权
    Therapeutic liposome composition and method 失效
    治疗脂质体组成及方法

    公开(公告)号：US06958241B2

    公开(公告)日：2005-10-25

    申请号：US10616094

    申请日：2003-07-08

    申请人： Francis J. Martin ,  Samuel Zalipsky ,  Shi Kun Huang

    发明人： Francis J. Martin ,  Samuel Zalipsky ,  Shi Kun Huang

    IPC分类号： A61K9/127 ,  A61K31/715 ,  A61K38/00 ,  A61K47/30 ,  A61P29/00 ,  A61P35/00 ,  C12N5/02 ,  C12N15/88 ,  C12N5/06 ,  C12N5/12

    CPC分类号： A61K9/1273 ,  A61K9/1271

    摘要： A method of liposome-based therapy for a mammalian subject is disclosed. The method uses liposomes with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic polymer coating effective to shield the affinity moiety from interaction with the target surface. The hydrophilic polymer coating is made up of polymer chains covalently linked to surface lipid components in the liposomes through releasable linkages. After a desired liposome biodistribution is achieved, a releasing agent is administered to cause cleaving of a substantial portion of the releasable linkages in the liposomes, to expose the affinity agent to the target surface.

    摘要翻译： 公开了一种哺乳动物受试者基于脂质体的治疗方法。 该方法使用具有外表面的脂质体，其具有有效结合治疗目的的生物表面的亲和部分，以及有效屏蔽亲和部分与靶表面相互作用的亲水性聚合物涂层。 亲水性聚合物涂层由通过可释放键连接到脂质体中的表面脂质组分的聚合物链组成。 在实现期望的脂质体生物分布之后，施用释放剂以引起脂质体中大部分可释放连接的切割，以将亲和剂暴露于靶表面。

    Releasable linkage and compositions containing same
    10.
    发明授权
    Releasable linkage and compositions containing same 有权
    可释放的连接物和含有它们的组合物

    公开(公告)号：US07592307B2

    公开(公告)日：2009-09-22

    申请号：US11810931

    申请日：2007-06-06

    申请人： Samuel Zalipsky ,  Radwan Kiwan

    发明人： Samuel Zalipsky ,  Radwan Kiwan

    IPC分类号： A01N37/18 ,  A61K38/00 ,  C08B11/00 ,  C25D3/60 ,  A61K9/127

    CPC分类号： A61K47/554 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61K47/544 ,  A61K47/60

    摘要： A conjugate comprised of a hydrophilic polymer covalently yet reversibly linked to a amine-, hydroxy- or carboxyl-containing ligand is described. The resulting conjugate is capable of releasing the parent amine, hydroxy, or carboxyl-containing compound via thiol-mediated cleavage. The system allows for delivery of various amino-, hydroxy-, or carboxy-containing drugs in the form of their thiolytically cleavable macromolecular conjugates.

    摘要翻译： 描述了由共价但可逆地连接到含胺，羟基或羧基的配体的亲水性聚合物组成的缀合物。 所得的缀合物能够通过硫醇介导的切割释放母体胺，羟基或含羧基的化合物。 该系统允许以其可硫裂解的大分子缀合物的形式递送各种氨基，羟基或羧基的药物。