公开(公告)号：US20240140975A1

公开(公告)日：2024-05-02

申请号：US18519408

申请日：2023-11-27

申请人： Shanghai Institute of Materia Medica, Chinese Academyof Sciences ,  Wuhan Institute ofVirology, Chinese Academy of Science ,  Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Science ,  Vigonvita Life Sciences Co., Ltd.

发明人： Yuanchao XIE ,  Gengfu Xiao ,  Yang He ,  Leike Zhang ,  Haji Akber Aisa ,  Hualiang Jiang ,  Jingshan Shen

IPC分类号： C07H7/06 ,  A61P31/14 ,  A61P31/16

CPC分类号： C07H7/06 ,  A61P31/14 ,  A61P31/16 ,  C07B2200/05

摘要： The present invention relates to an antiviral application of nucleoside analogs. Specifically, the present invention relates to uses of nucleoside analogs and a pharmaceutical composition thereof as: (a) inhibitors for inhibiting the replication of coronaviruses, influenza viruses, respiratory syncytial viruses, flaviviridae viruses, filoviridae viruses and/or porcine epidemic diarrhea virus (PEDV); and/or (b) medicines for treating and/or preventing and mitigating diseases caused by coronavirus, influenza virus, respiratory syncytial virus, flaviviridae virus, filoviridae virus and/or porcine epidemic diarrhea virus (PEDV) infections. The nucleoside analogs according to the invention may treat and/or prevent and mitigate respiratory infection, pneumonia (COVID-19) and other related diseases caused by 2019 novel coronavirus infection.

公开(公告)号：US11938567B1

公开(公告)日：2024-03-26

申请号：US18220297

申请日：2023-07-11

申请人： XINJIANG TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY, CHINESE ACADEMY OF SCIENCE

发明人： Linjun Li ,  Shilie Pan ,  Xiaoming Duan ,  Yu Zhou ,  Yingjie Shen ,  Qianqian Hao ,  Yuqiang Yang ,  Xin He

IPC分类号： B23K26/21 ,  B23K26/046 ,  B23K26/06 ,  B23K26/073 ,  B23K26/70

CPC分类号： B23K26/21 ,  B23K26/046 ,  B23K26/0643 ,  B23K26/0648 ,  B23K26/0652 ,  B23K26/073

摘要： A laser fusion welding device includes a 1.9 μm laser light source, a control unit and a light spot adjusting device. The control unit is configured to control the laser light source and the light spot adjusting device to adjust a laser power density at an object to be subjected to fusion welding. The 1.9 μm laser light source has output power of 100-500 W. The control unit includes a time control unit, a power control unit and a light spot control unit. The time control unit is configured to control a turn-on time of the laser light source. The power control unit is configured to control the output power of the laser light source. The light spot control unit is configured to control the light spot adjusting device to adjust a size of a light spot at the object to be subjected to fusion welding.