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1.发明申请公开(公告)号：US20140219979A1
公开(公告)日：2014-08-07
申请号：US14221887
申请日：2014-03-21
Inventor： Irun R. Cohen , Alexandra Zanin-Zhorov , Guy Tal , Francisco Quintana , Meirav Pisner , Ofer Lider
CPC classification number: A61K38/1709 , A61K35/17 , A61K39/0008 , A61K2035/124 , A61K2039/5158 , A61K2039/53 , C12N5/0636 , C12N2501/07
Abstract: The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.
Abstract translation: 本发明提供了人类热休克蛋白60（HSP60）的肽p277-位置437-460在调节免疫应答和炎性疾病方面的新用途。 本发明进一步提供HSP60和p277在治疗或预防肝病中的新用途。 本发明公开了治疗，预防或改善T细胞介导的炎症和自身免疫性疾病（包括肝脏疾病）的症状的方法，其包括向有需要的受试者施用包含有效量的选自以下的分子的组合物： HSP60，p277，其片段，类似物，同源物及其衍生物，以及编码其的核酸。 还公开了用于治疗或预防T细胞介导的病症的T细胞疫苗接种方法。
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公开(公告)号：US12286439B2
公开(公告)日：2025-04-29
申请号：US17337570
申请日：2021-06-03
Applicant: Yeda Research and Development Co. Ltd. , Universitat de Barcelona , Institució Catalana de Recerca I Estudis Avançats
Inventor： Rony Seger , Karen Flores , Xavier Barril Alonso , Carlos Galdeano Cantador
IPC: C07D498/04 , A61K45/06 , A61P35/00
Abstract: Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R′1 are aryl or heteroaryl as defined herein; and R2 and R′2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.
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3.发明申请公开(公告)号：US20250127783A1
公开(公告)日：2025-04-24
申请号：US18694557
申请日：2022-09-23
Applicant: DANA-FARBER CANCER INSTITUTE, INC. , BETH ISRAEL DEACONESS MEDICAL CENTER, INC. , YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Shizhong KE , Gerburg WULF , Xiao Zhen ZHOU , Nir LONDON , Wenyi WEI , Kun Ping LU , Nathanael S. GRAY , Behnam NABET
IPC: A61K31/519 , A61K31/203 , A61K31/381 , A61K31/506 , A61K33/36 , A61P35/00 , C07K16/28
Abstract: Disclosed are methods of treating diseases or disorders mediated by dysregulated CDK4/6 and/or Pin 1 activity comprising co-administering a therapeutically effective amount of one or more CDK4/6 inhibitors, and a therapeutically effective amount of one or more Pin1 inhibitors, or a pharmaceutically acceptable salt or salts thereof
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公开(公告)号：US20250127492A1
公开(公告)日：2025-04-24
申请号：US19001657
申请日：2024-12-26
Applicant: New York University , Yeda Research And Development Co. Ltd
Inventor： Itay KEZURER , Achiau LUDOMIRSKY , Yaron LIPMAN
Abstract: A system and method for detecting at least one cardiac anomaly includes a specifically configured computer hardware arrangement configured to receive ultrasound imaging information related to a heart of a patient and to use at least one neural network trained on multiple recognition and analysis procedures to detect at least one anomaly and/or to classify a severity of at least one anomaly.
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公开(公告)号：US20250122311A1
公开(公告)日：2025-04-17
申请号：US18681143
申请日：2022-08-05
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Sarel FLEISHMAN , Ariel TENNENHOUSE
Abstract: Provided herein is a method for obtaining a humanized antibody based on a non-human antibody having an affinity to an antigen of interest, that starts from an experimental or model structure, grafts the non-human CDRs on a library of human frameworks and uses restrained/constrained atomistic simulations to relax and rank the designs by energy.
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Patent Agency Ranking
公开(公告)号：US20250092158A1
公开(公告)日：2025-03-20
申请号：US18832710
申请日：2022-08-04
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Deborah FASS , Sarel FLEISHMAN , Lev KHMELNITSKY , Ariel TENNENHOUSE
IPC: C07K16/40 , A61K39/00 , A61K47/68 , G01N33/573
Abstract: The present invention provides humanized monoclonal antibodies that specifically recognize human QSOX1 and inhibit its activity. The humanized antibodies of the present invention were designed following in-silico selection of specific variable region segments, based on their energy scores, and were produced and confirmed to function properly in binding and inhibiting human QSOX1. The present invention further provides pharmaceutical compositions comprising the humanized antibodies and methods for their use in cancer therapy and diagnosis.
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公开(公告)号：US12232496B2
公开(公告)日：2025-02-25
申请号：US17040227
申请日：2019-03-21
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD
Inventor： Asaph Aharoni , Elisa Korenblum
IPC: A01N63/20 , A01G29/00 , A01N63/38 , A61K36/185 , A61K36/81 , C07D305/14 , C07J17/00
Abstract: Provided is a plant exudate, methods for obtaining a plant exudate by inducing the plant to secrete an exudate and systems for the collection of a plant exudate which include: one or more plant container including at least two discrete compartments each configured to accommodate a split root of a plant, the compartments being a root stimulating compartment including one or more input being in fluid communication with at least a source of a plant root stimulant, and a root exudate harvesting compartment, and a root exudate collection compartment in fluid communication with the root exudate harvesting compartment.
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公开(公告)号：US20250051833A1
公开(公告)日：2025-02-13
申请号：US18721921
申请日：2022-12-26
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Sergey N. SEMENOV , Ekaterina V. SKORB
IPC: C12Q1/6834 , C12Q1/6876
Abstract: Provided herein a supramolecular assembly comprising a solid porous particle comprising a single-stranded polynucleotide encapsulated by non-covalent organic structure. Specifically, the non-covalent organic structure is melamine-cyanurate, and the single-stranded polynucleotide is ssDNA or ssRNA.
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公开(公告)号：US20250032566A1
公开(公告)日：2025-01-30
申请号：US18713665
申请日：2022-12-05
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Rotem SOREK , Erez YIRMIYA , Azita LEAVITT , Gil AMITAI , Jeremy Elliot GARB
Abstract: Genetically modified phages are provided. Accordingly, there is provided a genetically modified phage comprising a polynucleotide encoding an anti-defense system polypeptide. Also provided are methods of producing and using same.
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公开(公告)号：US12198012B2
公开(公告)日：2025-01-14
申请号：US18299821
申请日：2023-04-13
Inventor： Gil Semo , Ziv Aqua , Oded Melamed , Dan Charash , Serge Rosenblum , Barak Dayan
Abstract: A quantum computing system, method, and computer readable medium involves initializing a state of a resonator-coupled quantum emitter having at least four levels arranged in an N-configuration, the N-configuration having a first ground state, a second ground state, a first excited state and a second excited state. A frequency of a first transition between the first ground state and the first excited state is tuned, a frequency of a second transition between the second ground state and the second excited state is tuned, and a frequency of a third transition between the second ground state and the first excited state is tuned. A plurality of photons are fed at a frequency corresponding to the frequency of the second transition, thereby entangling the plurality of photons to the resonator-coupled quantum emitter. Likewise, a photon at a frequency corresponding to the frequency of at least one of the first transition or the third transition is fed, thereby mapping a state of the resonator-coupled quantum emitter into a photon.
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