公开(公告)号：US20180185477A1

公开(公告)日：2018-07-05

申请号：US15898780

申请日：2018-02-19

Applicant: Yeda Research and Development Co. Ltd. ,  Arizona Board of Regents for and on behalf of Arizona State University

Inventor： Douglas LAKE ,  Benjamin KATCHMAN ,  Deborah FASS

IPC: A61K39/395

CPC classification number: A61K39/3955 ,  A61K38/44 ,  A61K39/39558 ,  A61K2121/00 ,  C07K16/40 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12Q1/26 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Y108/03002 ,  G01N33/5008 ,  G01N33/5011

Abstract: The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

公开(公告)号：US20180273639A1

公开(公告)日：2018-09-27

申请号：US15961928

申请日：2018-04-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah FASS ,  Iris Grossman ,  Tal Ilani

IPC: C07K16/40 ,  C07K16/18 ,  A61K39/395

CPC classification number: C07K16/40 ,  A01K2227/105 ,  A01K2267/0306 ,  A61K39/395 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/18 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1 is disclosed. Methods of producing the antibody, pharmaceutical compositions comprising the antibody and methods of using the antibody for treating medical conditions are also disclosed.

公开(公告)号：US20170247468A1

公开(公告)日：2017-08-31

申请号：US15494585

申请日：2017-04-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah FASS ,  Iris GROSSMAN ,  Tal ILANI ,  Assaf ALON

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y108/03002

Abstract: A method of inhibiting or preventing laminin assembly in a basement membrane is disclosed. The method comprising contacting a tissue with an agent which inhibits QSOX1 activity or expression, thereby inhibiting or preventing laminin assembly in the basement membrane.

公开(公告)号：US20250092158A1

公开(公告)日：2025-03-20

申请号：US18832710

申请日：2022-08-04

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Deborah FASS ,  Sarel FLEISHMAN ,  Lev KHMELNITSKY ,  Ariel TENNENHOUSE

IPC: C07K16/40 ,  A61K39/00 ,  A61K47/68 ,  G01N33/573

Abstract: The present invention provides humanized monoclonal antibodies that specifically recognize human QSOX1 and inhibit its activity. The humanized antibodies of the present invention were designed following in-silico selection of specific variable region segments, based on their energy scores, and were produced and confirmed to function properly in binding and inhibiting human QSOX1. The present invention further provides pharmaceutical compositions comprising the humanized antibodies and methods for their use in cancer therapy and diagnosis.

公开(公告)号：US20210292437A1

公开(公告)日：2021-09-23

申请号：US17267049

申请日：2019-08-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah FASS ,  Sarel FLEISHMAN ,  Shira WARSZAWSKI ,  Iris GROSSMAN ,  Lev KHMELNITSKY

IPC: C07K16/40

Abstract: Antibodies for binding QSOX1 are provided. Also provided are use of these antibodies.

公开(公告)号：US20210147575A1

公开(公告)日：2021-05-20

申请号：US17087765

申请日：2021-02-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah FASS ,  Iris GROSSMAN ,  Tal ILANI

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/18

Abstract: An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1 is disclosed. Methods of producing the antibody, pharmaceutical compositions comprising the antibody and methods of using the antibody for treating medical conditions are also disclosed.

公开(公告)号：US20170182158A1

公开(公告)日：2017-06-29

申请号：US15242646

申请日：2016-08-22

Applicant: Yeda Research and Development Co. Ltd. ,  Arizona Board of Regents for and on behalf of Arizona State University

Inventor： Douglas LAKE ,  Benjamin KATCHMAN ,  Deborah FASS

IPC: A61K39/395

CPC classification number: A61K39/3955 ,  A61K38/44 ,  A61K39/39558 ,  A61K2121/00 ,  C07K16/40 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12Q1/26 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Y108/03002 ,  G01N33/5008 ,  G01N33/5011

Abstract: The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.