公开(公告)号：US20080138913A1

公开(公告)日：2008-06-12

申请号：US11722712

申请日：2006-01-02

申请人： Sook-Yeong Jeon ,  Dong-Ho Nahm

发明人： Sook-Yeong Jeon ,  Dong-Ho Nahm

IPC分类号： G01N33/00

CPC分类号： A61K38/51 ,  C12Y402/01011 ,  G01N33/564 ,  G01N33/68 ,  G01N2800/12 ,  G01N2800/122

摘要： A pharmaceutical composition for preventing or treating chronic inflammatory airway diseases comprising alpha-enolase protein as an active ingredient is provided. The present invention also provides a diagnostic composition and a diagnostic kit for diagnosing chronic inflammatory airway diseases comprising alpha-enolase protein. The present invention further provides a composition for screening a therapeutic agent for chronic inflammatory airway diseases, comprising one or more of alpha-enolase protein or autoantibodies to alpha-enolase obtained from patients with chronic inflammatory airway diseases, and a method for screening a therapeutic agent for chronic inflammatory airway diseases using this composition. The present invention still further provides methods for diagnosing, preventing or treating chronic inflammatory airway diseases using alpha-enolase protein.

摘要翻译： 提供了用于预防或治疗包含α-烯醇化酶蛋白作为活性成分的慢性炎性气道疾病的药物组合物。 本发明还提供用于诊断包括α-烯醇酶蛋白质的慢性炎性气道疾病的诊断组合物和诊断试剂盒。 本发明还提供一种用于筛选慢性炎症性气道疾病治疗剂的组合物，其包含由慢性炎性气道疾病患者获得的α-烯醇化酶的α-烯醇化酶蛋白质或自身抗体中的一种或多种，​​以及用于筛选治疗剂的方法 用于使用该组合物的慢性炎性气道疾病。 本发明还提供了使用α-烯醇化酶蛋白诊断，预防或治疗慢性炎性气道疾病的方法。

公开(公告)号：US20090234140A1

公开(公告)日：2009-09-17

申请号：US11721366

申请日：2004-12-20

申请人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

发明人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

IPC分类号： C07D495/04

CPC分类号： C07D495/04 ,  C07B57/00

摘要： Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.

摘要翻译： 本文公开了使用模拟移动床吸附分离方法制造光学活性噻吩类化合物的方法，更具体地说，是将外消旋噻吩类化合物连续分离成其高纯度的光学活性噻吩类化合物的方法， 通过使用模拟移动床过程的光学分辨率。 根据本发明的方法，可以将噻吩类化合物的外消旋混合物连续分离成其高纯度的光学活性噻吩类化合物，其是用作青光眼的局部治疗剂的光学活性多吡咯酰胺的中间体 ，使用模拟移动床吸附分离技术，从而提高工业可用性。

公开(公告)号：US20080038252A1

公开(公告)日：2008-02-14

申请号：US11908806

申请日：2006-03-17

申请人： Sook-yeong Jeon ,  Dong-ho Nahm

发明人： Sook-yeong Jeon ,  Dong-ho Nahm

IPC分类号： A61K39/395 ,  A61P37/08

CPC分类号： C07K16/18 ,  A61K2039/505

摘要： The present invention provides a pharmaceutical composition comprising histamine, immunoglobulin and allergen as active ingredients. Also, the present invention provides a kit for treating allergic diseases comprising the above active ingredients. The present invention also provides use of a composition comprising histamine, immunoglobulin and allergen as active ingredients for the manufacture of medicament for treating allergic diseases. Further, the present invention provides a method of treating allergic diseases which comprises administrating the pharmaceutical composition comprising a therapeutically effective amount of histamine, immunoglobulin and allergen to a mammal. Therefore, the allergic diseases can be significantly improved in the patients with refractory allergic diseases who could not be sufficiently improved by treatment with standard drug therapy or allergen-immunotherapy if the pharmaceutical composition, its use for treating allergic diseases, or the treating method using the above compositions of the present invention was applied.

摘要翻译： 本发明提供包含组胺，免疫球蛋白和变应原作为活性成分的药物组合物。 此外，本发明提供了用于治疗包含上述活性成分的过敏性疾病的试剂盒。 本发明还提供包含组胺，免疫球蛋白和变应原的组合物作为制备用于治疗过敏性疾病的药物的活性成分的用途。 此外，本发明提供了治疗过敏性疾病的方法，其包括向哺乳动物施用包含治疗有效量的组胺，免疫球蛋白和变应原的药物组合物。 因此，如果药物组合物，其用于治疗过敏性疾病的治疗方法或使用该治疗方法的治疗方法，则通过用标准药物治疗或变应原免疫治疗进行治疗而不能充分改善的难治性过敏性疾病患者的过敏性疾病可以显着改善 应用上述本发明的组合物。

公开(公告)号：US06262621B1

公开(公告)日：2001-07-17

申请号：US09559236

申请日：2000-04-26

申请人： Baek-Yeong Jeon

发明人： Baek-Yeong Jeon

IPC分类号： G05F110

CPC分类号： H03K5/08 ,  G11C5/145

摘要： A voltage boosting circuit of a semiconductor device is disclosed. The voltage boosting circuit includes a voltage detector, an active kicker controller, and an active kicker. The voltage detector generates a detection signal after the determining whether a potential of the signal to be boosted is higher than a boost voltage target level. The active kicker controller generates an active kicker control signal in response to the detection signal and the clock signal. The active kicker drives the signal to be boosted in response to the active kicker control signal. The voltage detector includes a current source, a number of switching devices, a current compensating circuit, and an inverter circuit. The current compensating circuit provides a compensating current proportional to a power supply voltage.

摘要翻译： 公开了一种半导体器件的升压电路。 升压电路包括电压检测器，有源激光控制器和主动激光器。 电压检测器在确定要升压的信号的电位是否高于升压电压目标电平之后产生检测信号。 主动踢球控制器响应于检测信号和时钟信号产生有效的踢球者控制信号。 响应于主动的发射器控制信号，主动的踢球器驱动要被升压的信号。 电压检测器包括电流源，多个开关器件，电流补偿电路和反相器电路。 电流补偿电路提供与电源电压成比例的补偿电流。

公开(公告)号：US20080299045A1

公开(公告)日：2008-12-04

申请号：US11883589

申请日：2006-02-03

申请人： Sook-yeong Jeon ,  Dong-ho Nam

发明人： Sook-yeong Jeon ,  Dong-ho Nam

IPC分类号： A61K49/14 ,  A61K38/17 ,  C07K14/47 ,  A61P11/00 ,  G01N33/567

CPC分类号： G01N33/6884 ,  A61K38/1748

摘要： The present invention provides a pharmaceutical composition for preventing or treating chronic obstructive pulmonary disease (COPD) comprising cytokeratin 18 protein as an active ingredient. The present invention also provides a diagnostic composition and a diagnostic kit for diagnosing COPD comprising cytokeratin 18 protein. The present invention further provides a composition for screening a therapeutic agent for COPD, comprising one or more of cytokeratin 18 protein or autoantibodies to cytokeratin 18 obtained from patients with COPD and a method for screening a therapeutic agent for COPD using this composition. The present invention still further provides methods for diagnosing, preventing or treating COPD using cytokeratin 18 protein.

摘要翻译： 本发明提供了用于预防或治疗包含细胞角蛋白18蛋白作为活性成分的慢性阻塞性肺病（COPD）的药物组合物。 本发明还提供用于诊断包含细胞角蛋白18蛋白的COPD的诊断组合物和诊断试剂盒。 本发明还提供一种用于筛选COPD治疗剂的组合物，其包含从COPD患者获得的细胞角蛋白18的细胞角蛋白18蛋白或自身抗体中的一种或多种，​​以及使用该组合物筛选COPD治疗剂的方法。 本发明还提供了使用细胞角蛋白18蛋白来诊断，预防或治疗COPD的方法。

公开(公告)号：US20070173468A9

公开(公告)日：2007-07-26

申请号：US10860844

申请日：2004-06-04

申请人： Yeong Jeon ,  Wan Park ,  Na Lee ,  Sang Jung ,  Doo Kim ,  Hyung Kwon

发明人： Yeong Jeon ,  Wan Park ,  Na Lee ,  Sang Jung ,  Doo Kim ,  Hyung Kwon

IPC分类号： A61K48/00 ,  C12Q1/68

CPC分类号： C12N9/22

摘要： The present invention relates to a novel endonuclease enzyme which is secreted from immune cell and recognizes bacterial DNA as foreign agent and processes it to produce about 10 bp single-stranded oligonucleotide including CpG motif which is involved in immune response. Also, the present invention relates to a process for producing the endonuclease which comprises culturing human B-lymphoblastic IM9 cell line or TPA-treated myelogenous U937 cell line on an appropriate medium to produce the said endonuclease and isolating the said endonuclease from the cell lysate or the culture medium. In addition, the present invention relates to an immune adjuvant comprising about 10 bp single-stranded oligonucleotide having CpG motif produced by treatment of bacterial DNA by the endonuclease.

摘要翻译： 本发明涉及从免疫细胞分泌并识别细菌DNA作为外来试剂的新型内切核酸酶，并将其处理以产生约10bp的单链寡核苷酸，包括参与免疫应答的CpG基序。 此外，本发明涉及生产内切核酸酶的方法，其包括在合适的培养基上培养人B淋巴细胞IM9细胞系或TPA处理的骨髓瘤U937细胞系以产生所述内切核酸酶并从细胞裂解物中分离所述内切核酸酶或 培养基。 此外，本发明涉及包含通过内切核酸酶处理细菌DNA产生的具有CpG基序的约10bp单链寡核苷酸的免疫佐剂。

公开(公告)号：US07981619B2

公开(公告)日：2011-07-19

申请号：US11883589

申请日：2006-02-03

申请人： Sook-yeong Jeon ,  Dong-ho Nahm

发明人： Sook-yeong Jeon ,  Dong-ho Nahm

IPC分类号： G01N33/53

CPC分类号： G01N33/6884 ,  A61K38/1748

摘要： The present invention provides a pharmaceutical composition for preventing or treating chronic obstructive pulmonary disease (COPD) comprising cytokeratin 18 protein as an active ingredient. The present invention also provides a diagnostic composition and a diagnostic kit for diagnosing COPD comprising cytokeratin 18 protein. The present invention further provides a composition for screening a therapeutic agent for COPD, comprising one or more of cytokeratin 18 protein or autoantibodies to cytokeratin 18 obtained from patients with COPD and a method for screening a therapeutic agent for COPD using this composition. The present invention still further provides methods for diagnosing, preventing or treating COPD using cytokeratin 18 protein.

摘要翻译： 本发明提供了用于预防或治疗包含细胞角蛋白18蛋白作为活性成分的慢性阻塞性肺病（COPD）的药物组合物。 本发明还提供用于诊断包含细胞角蛋白18蛋白的COPD的诊断组合物和诊断试剂盒。 本发明还提供一种用于筛选COPD治疗剂的组合物，其包含从COPD患者获得的细胞角蛋白18的细胞角蛋白18蛋白或自身抗体中的一种或多种，​​以及使用该组合物筛选COPD治疗剂的方法。 本发明还提供了使用细胞角蛋白18蛋白来诊断，预防或治疗COPD的方法。

公开(公告)号：US07767832B2

公开(公告)日：2010-08-03

申请号：US11721366

申请日：2004-12-20

申请人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

发明人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

IPC分类号： C07D495/06

CPC分类号： C07D495/04 ,  C07B57/00

摘要： Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.

摘要翻译： 本文公开了使用模拟移动床吸附分离方法制造光学活性噻吩类化合物的方法，更具体地说，是将外消旋噻吩类化合物连续分离成其高纯度的光学活性噻吩类化合物的方法， 通过使用模拟移动床过程的光学分辨率。 根据本发明的方法，可以将噻吩类化合物的外消旋混合物连续分离成其高纯度的光学活性噻吩类化合物，其是用作青光眼的局部治疗剂的光学活性多吡咯酰胺的中间体 ，使用模拟移动床吸附分离技术，从而提高工业可用性。

公开(公告)号：US20050208583A1

公开(公告)日：2005-09-22

申请号：US10514932

申请日：2003-05-12

申请人： Dong-Ho Nahm ,  Sook-Yeong Jeon

发明人： Dong-Ho Nahm ,  Sook-Yeong Jeon

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  C07K14/78 ,  G01N33/15 ,  G01N33/50 ,  G01N33/564 ,  G01N33/68

CPC分类号： G01N33/564 ,  A61K38/1709 ,  G01N2800/24 ,  G01N2800/52

摘要： The present invention is based on the surprising discovery of autoantibodies to cytokeratin 18 protein in the serum samples of patients with bronchial asthma and chronic rhinitis, especially in nonallergic patients. The present invention includes diagnostic methods and a diagnostic kit to detect patients with bronchial asthma and chronic rhinitis associated with autoantibodies to cytokeratin 18. The invention also includes methods and kits to prescribe or monitor treatment for patients with bronchial asthma and chronic rhinitis by detecting autoantibodies to cytokeratin 18. The present invention also includes a pharmaceutical formulation comprising cytokeratin 18 protein to protect patients with bronchial asthma and chronic rhinitis associated with autoantibodies to cytokeratin 18. The present invention also includes methods to treat patients with bronchial asthma and chronic rhinitis associated with autoantibodies to cytokeratin 18 using compounds that inhibit the interaction between such autoantibodies and cytokeratin 18 protein.

摘要翻译： 本发明基于在支气管哮喘和慢性鼻炎患者的血清样品中特别是非过敏性患者中对细胞角蛋白18蛋白的自身抗体的惊人发现。 本发明包括诊断方法和用于检测与细胞角蛋白18的自身抗体相关的支气管哮喘和慢性鼻炎患者的诊断试剂盒。本发明还包括通过检测自身抗体来开发或监测支气管哮喘和慢性鼻炎患者的治疗方法和试剂盒 细胞角蛋白18.本发明还包括含有细胞角蛋白18蛋白质的药物制剂，以保护患有支气管哮喘的患者和与细胞角蛋白18相关的自身抗体的慢性鼻炎。本发明还包括治疗患有支气管哮喘和与自身抗体相关的慢性鼻炎的患者的方法 使用抑制这种自身抗体和细胞角蛋白18蛋白之间相互作用的化合物的细胞角蛋白18。

公开(公告)号：US20050203039A1

公开(公告)日：2005-09-15

申请号：US10860844

申请日：2004-06-04

申请人： Yeong Jeon ,  Wan Park ,  Na Lee ,  Sang Jung ,  Doo Kim ,  Hyung Kwon

发明人： Yeong Jeon ,  Wan Park ,  Na Lee ,  Sang Jung ,  Doo Kim ,  Hyung Kwon

IPC分类号： C12N9/22 ,  A61K48/00 ,  C12Q1/68

CPC分类号： C12N9/22

摘要： The present invention relates to a novel endonuclease enzyme which is secreted from immune cell and recognizes bacterial DNA as foreign agent and processes it to produce about 10 bp single-stranded oligonucleotide including CpG motif which is involved in immune response. Also, the present invention relates to a process for producing the endonuclease which comprises culturing human B-lymphoblastic IM9 cell line or TPA-treated myelogenous U937 cell line on an appropriate medium to produce the said endonuclease and isolating the said endonuclease from the cell lysate or the culture medium. In addition, the present invention relates to an immune adjuvant comprising about 10 bp single-stranded oligonucleotide having CpG motif produced by treatment of bacterial DNA by the endonuclease.

摘要翻译： 本发明涉及从免疫细胞分泌并识别细菌DNA作为外来试剂的新型内切核酸酶，并将其处理以产生约10bp的单链寡核苷酸，其包括参与免疫应答的CpG基序。 此外，本发明涉及生产内切核酸酶的方法，其包括在合适的培养基上培养人B淋巴细胞IM9细胞系或TPA处理的骨髓瘤U937细胞系以产生所述内切核酸酶并从细胞裂解物中分离所述内切核酸酶或 培养基。 此外，本发明涉及包含通过内切核酸酶处理细菌DNA产生的具有CpG基序的约10bp单链寡核苷酸的免疫佐剂。