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公开(公告)号：US10047334B2
公开(公告)日：2018-08-14
申请号：US15064918
申请日：2016-03-09
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Jeffrey D. Smith , RuthAnn R. Duda , Brian J. Engel
Abstract: A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
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公开(公告)号：US09540677B2
公开(公告)日：2017-01-10
申请号：US14488332
申请日：2014-09-17
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati , RuthAnn R. Duda
CPC classification number: C12Q1/22
Abstract: A biological sterilization indicator (BI) and method of using same. The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a first fluid path positioned to fluidly couple the first chamber and the second chamber, and a second fluid path positioned to allow displaced gas to move out of the second chamber. The method can include moving displaced gas out of the second chamber via the second fluid path as a sterilant is moved into the second chamber via the first fluid path and/or as the liquid is moved into the second chamber via the first fluid path.
Abstract translation: 生物灭菌指示剂（BI）及其使用方法。 BI可以包括壳体和位于壳体中的容器。 容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。 第二室可以包括至少一种生物活性来源。 BI还可以包括定位成流体耦合第一室和第二室的第一流体路径，以及定位成允许排出的气体移出第二室的第二流体路径。 该方法可以包括当消毒剂经由第一流体路径移动到第二室中时和/或当液体经由第一流体路径移动到第二室中时，通过第二流体路径将移动的气体移出第二室。
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公开(公告)号：US20150165082A1
公开(公告)日：2015-06-18
申请号：US14625176
申请日：2015-02-18
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
Abstract: A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
Abstract translation: 一种生物灭菌指标，系统和确定灭菌过程有效性的方法。 生物灭菌指示剂可以包括孢子的位点，含有液体的储存器和定位成在气氛和孢子的位置之间提供流体连通的消毒剂通道。 储存器可以具有闭合状态，其中储存器不与孢子的轨迹流体连通，并且储存器与孢子的轨迹流体连通的打开状态。 生物灭菌指示器系统可以包括生物灭菌指示器和适于联接到生物灭菌指示器的检测装置。 在一些实施方案中，该方法可以包括测定孢子以获得特征的可检测变化，并且检测基本上所有可检测的变化。
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公开(公告)号：US20150353984A1
公开(公告)日：2015-12-10
申请号：US14828997
申请日：2015-08-18
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jeffrey C. Pederson , Sailaja Chandrapati , Bryan S. Behun , Barry W. Robole , Leroy J. Longworth
IPC: C12Q1/22
Abstract: A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a first “unactivated” position and a second “activated” position. The BI can further include a frangible container containing a liquid and dimensioned to be positioned in the housing. The reading apparatus can be configured to detect activation of the biological sterilization indicator, for example, by detecting that the second portion is in the second position, and/or by detecting that the liquid from the frangible container is present in a specific chamber of the biological sterilization indicator. The method can include positioning the BI in the well of the reading apparatus and detecting activation, for example, by detecting one or more of the above conditions.
Abstract translation: 一种生物灭菌指标（BI）系统及方法。 该系统可以包括BI和包括井的读取装置。 BI可以包括壳体，其可以包括第一部分，以及可在第一“未激活”位置和第二“激活”位置之间移动的第二部分。 BI还可以包括容纳液体并且尺寸设置在壳体中的易碎容器。 读取装置可以被配置为检测生物灭菌指示器的激活，例如通过检测第二部分处于第二位置，和/或通过检测来自易碎容器的液体存在于 生物灭菌指标。 该方法可以包括将BI定位在读取装置的阱中并检测激活，例如通过检测上述一个或多个条件。
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公开(公告)号：US09279141B2
公开(公告)日：2016-03-08
申请号：US14453797
申请日：2014-08-07
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Kurt J. Halverson , Brian J. Engel
Abstract: The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. The second indicator reagent is converted by the predetermined biological activity to a second biological derivative with a second emission spectrum. The first absorbance spectrum includes detectable absorbance in at least a portion of wavelengths present in the second emission spectrum. The first indicator reagent is received and concentrated from an aqueous liquid by a substrate, facilitating the detection of the second biological derivative.
Abstract translation: 本发明提供了检测预定生物活性的方法。 该方法包括使用包含具有第一吸收光谱的第一指示剂和第二指示剂试剂的含水混合物。 第二指示剂通过预定的生物活性转化为具有第二发射光谱的第二生物衍生物。 第一吸收光谱包括在第二发射光谱中存在的波长的至少一部分中的可检测吸光度。 第一指示剂被含水液体接收并通过底物浓缩，便于检测第二生物衍生物。
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Patent Agency Ranking
公开(公告)号：US09717812B2
公开(公告)日：2017-08-01
申请号：US14625176
申请日：2015-02-18
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
Abstract: A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
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公开(公告)号：US20150167047A1
公开(公告)日：2015-06-18
申请号：US14623965
申请日：2015-02-17
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
IPC: C12Q1/22
Abstract: A biological sterilization indicator (BI) and a method of using same for assaying the lethality of a sterilization process. The BI can include a housing, which can include a first portion, and a second portion, which can be movable with respect to the first portion between a first and second position. The BI can further include a frangible container comprising a liquid. The BI can further include a spore reservoir and a projection positioned in the housing. The projection can be configured to fracture the container when the second portion of the housing is moved from the first position to the second position. The method can include maintaining a minimal cross-sectional area of space around the container when the second portion of the housing is in the first position, and fracturing the container in response to moving the second portion between the first and second positions.
Abstract translation: 生物灭菌指示剂（BI）及其用于测定灭菌过程的致死性的方法。 BI可以包括可以包括第一部分的壳体和可以在第一和第二位置之间相对于第一部分移动的第二部分。 BI可进一步包括包含液体的易碎容器。 BI还可以包括孢子贮存器和位于壳体中的突起。 当壳体的第二部分从第一位置移动到第二位置时，突出部可以构造成使容器破裂。 该方法可以包括当壳体的第二部分处于第一位置时保持围绕容器的最小的空间横截面面积，并响应于在第一和第二位置之间移动第二部分而破裂容器。
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公开(公告)号：US20150004682A1
公开(公告)日：2015-01-01
申请号：US14488332
申请日：2014-09-17
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati , RuthAnn R. Duda
IPC: C12Q1/22
CPC classification number: C12Q1/22
Abstract: A biological sterilization indicator (BI) and method of using same. The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a first fluid path positioned to fluidly couple the first chamber and the second chamber, and a second fluid path positioned to allow displaced gas to move out of the second chamber. The method can include moving displaced gas out of the second chamber via the second fluid path as a sterilant is moved into the second chamber via the first fluid path and/or as the liquid is moved into the second chamber via the first fluid path.
Abstract translation: 生物灭菌指示剂（BI）及其使用方法。 BI可以包括壳体和位于壳体中的容器。 容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。 第二室可以包括至少一种生物活性来源。 BI还可以包括定位成流体耦合第一室和第二室的第一流体路径，以及定位成允许排出的气体移出第二室的第二流体路径。 该方法可以包括当消毒剂经由第一流体路径移动到第二室中时和/或当液体经由第一流体路径移动到第二室中时，通过第二流体路径将移动的气体移出第二室。
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公开(公告)号：US09701996B2
公开(公告)日：2017-07-11
申请号：US14623965
申请日：2015-02-17
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jeffrey D. Smith , Jeffrey C. Pederson , Sailaja Chandrapati
Abstract: A biological sterilization indicator (BI) and a method of using same for assaying the lethality of a sterilization process. The BI can include a housing, which can include a first portion, and a second portion, which can be movable with respect to the first portion between a first and second position. The BI can further include a frangible container comprising a liquid. The BI can further include a spore reservoir and a projection positioned in the housing. The projection can be configured to fracture the container when the second portion of the housing is moved from the first position to the second position. The method can include maintaining a minimal cross-sectional area of space around the container when the second portion of the housing is in the first position, and fracturing the container in response to moving the second portion between the first and second positions.
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公开(公告)号：US09428786B2
公开(公告)日：2016-08-30
申请号：US14828997
申请日：2015-08-18
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Jeffrey C. Pederson , Sailaja Chandrapati , Bryan S. Behun , Barry W. Robole , Leroy J. Longworth
Abstract: A biological sterilization indicator (BI) system and method. The system can include a BI and a reading apparatus comprising a well. The BI can include a housing, which can include a first portion, and a second portion movable between a first “unactivated” position and a second “activated” position. The BI can further include a frangible container containing a liquid and dimensioned to be positioned in the housing. The reading apparatus can be configured to detect activation of the biological sterilization indicator, for example, by detecting that the second portion is in the second position, and/or by detecting that the liquid from the frangible container is present in a specific chamber of the biological sterilization indicator. The method can include positioning the BI in the well of the reading apparatus and detecting activation, for example, by detecting one or more of the above conditions.
Abstract translation: 一种生物灭菌指标（BI）系统及方法。 该系统可以包括BI和包括井的读取装置。 BI可以包括壳体，其可以包括第一部分，以及可在第一“未激活”位置和第二“激活”位置之间移动的第二部分。 BI还可以包括容纳液体并且尺寸设置在壳体中的易碎容器。 读取装置可以被配置为检测生物灭菌指示器的激活，例如通过检测第二部分处于第二位置，和/或通过检测来自易碎容器的液体存在于 生物灭菌指标。 该方法可以包括将BI定位在读取装置的阱中并检测激活，例如通过检测上述一个或多个条件。
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