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公开(公告)号：US09916491B2
公开(公告)日：2018-03-13
申请号：US15593583
申请日：2017-05-12
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Phillip A. Bolea , Michael G. Williams
CPC classification number: G06K9/00147 , G06K9/00134 , G06K9/0014 , G06T7/149 , G06T7/62 , G06T7/70 , G06T2207/10016 , G06T2207/10056 , G06T2207/10152 , G06T2207/20124 , G06T2207/30242
Abstract: A first method comprises using an imaging device to produce a plurality of images of a culture device, analyzing a first image to identify a microorganism colony at a first location, analyzing a second image to identify a gas bubble at a second location, and determining whether the first location is proximate the second location. A second method comprises analyzing an image of a culture device to detect gas bubbles and classifying the gas bubbles according to a size parameter associated with each of the gas bubbles. A third method comprises analyzing a first area of an image of a culture device to detect a first number of gas bubbles, analyzing a second area of the image to detect a second number of gas bubbles, and comparing the first number of gas bubbles to the second number of gas bubbles.
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公开(公告)号：US09684816B2
公开(公告)日：2017-06-20
申请号：US14652379
申请日：2013-12-13
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Phillip A. Bolea , Michael G. Williams
CPC classification number: G06K9/00147 , G06K9/00134 , G06K9/0014 , G06T7/149 , G06T7/62 , G06T7/70 , G06T2207/10016 , G06T2207/10056 , G06T2207/10152 , G06T2207/20124 , G06T2207/30242
Abstract: A first method comprises using an imaging device to produce a plurality of images of a culture device, analyzing a first image to identify a microorganism colony at a first location, analyzing a second image to identify a gas bubble at a second location, and determining whether the first location is proximate the second location. A second method comprises analyzing an image of a culture device to detect gas bubbles and classifying the gas bubbles according to a size parameter associated with each of the gas bubbles. A third method comprises analyzing a first area of an image of a culture device to detect a first number of gas bubbles, analyzing a second area of the image to detect a second number of gas bubbles, and comparing the first number of gas bubbles to the second number of gas bubbles.
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公开(公告)号：US09677108B2
公开(公告)日：2017-06-13
申请号：US14652366
申请日：2013-12-13
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Phillip A. Bolea
IPC: G06K9/00 , C12Q1/04 , G01N33/569
CPC classification number: C12Q1/04 , G01N33/569 , G06K9/00134 , G06K9/00147
Abstract: A method of identifying microbial colonies in a culture device is provided. The method comprises using an imaging device to produce a first image of a thin film culture device while providing illumination to a front side of the device and to produce a second image of the thin film culture device while providing illumination to a back side of the device. The method further comprises analyzing the first and second images to identify microorganism colonies in each image, analyzing the first and second images values of a size parameter for a colony at a particular location in the culture device, and comparing the values. The method can be used to differentiate and count at least two colony types.
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公开(公告)号：USD759520S1
公开(公告)日：2016-06-21
申请号：US29520388
申请日：2015-03-13
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Designer： Phillip A. Bolea , Thomas J. Brace , Thomas E. Dewey, Jr. , Arthur V. Lang , Fusu Thao
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公开(公告)号：US08588505B2
公开(公告)日：2013-11-19
申请号：US13783511
申请日：2013-03-04
Applicant: 3M Innovative Properties Company
Inventor： Phillip A. Bolea
CPC classification number: G06K9/00127 , C12M41/36 , C12M41/48 , C12Q1/06 , G01N21/359 , G01N33/48735
Abstract: This disclosure is directed to imaging techniques and image analysis techniques for automated analysis of biological growth media. According to this disclosure, the spectral responses of biological growth media can be used to identify and count biological agents from images of biological growth media. The biological growth media may be illuminated with two or more different wavelengths of electromagnetic radiation, and images of the biological growth media can be captured under these different illuminations. The spectral reflectance values in one or more first images can be normalized based on the spectral reflectance values in one or more second images, wherein the first images are associated with a different wavelength of illumination than the second images. The normalization may allow for better identification of biological agents that manifest on the biological growth media.
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Patent Agency Ranking
公开(公告)号：US09809836B2
公开(公告)日：2017-11-07
申请号：US15590193
申请日：2017-05-09
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Phillip A. Bolea
IPC: G06K9/00 , C12Q1/04 , G01N33/569
CPC classification number: C12Q1/04 , G01N33/569 , G06K9/00134 , G06K9/00147
Abstract: A method of identifying microbial colonies in a culture device is provided. The method comprises using an imaging device to produce a first image of a thin film culture device while providing illumination to a front side of the device and to produce a second image of the thin film culture device while providing illumination to a back side of the device. The method further comprises analyzing the first and second images to identify microorganism colonies in each image, analyzing the first and second images values of a size parameter for a colony at a particular location in the culture device, and comparing the values. The method can be used to differentiate and count at least two colony types.
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公开(公告)号：US11022564B2
公开(公告)日：2021-06-01
申请号：US16785849
申请日：2020-02-10
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Thomas J. Brace , Phillip A. Bolea , Giuseppe M. Bommarito , Michele A. Waldner , Stephen R. Alexander , Fusu Thao , Kathleen M. Stenersen
Abstract: Various embodiments of a light detection device and a method of using the device are disclosed. In one or more embodiments, the light detection device can include a housing that extends along a housing axis between top and bottom surfaces. The device can also include a port that is adapted to receive a sample, and a door connected to the housing. The door can include an actuator portion adapted to selectively move the door between a closed position and an open position, and a cover portion connected to the actuator portion and adapted to close the port when the door is in the closed position and open the port when the door is in the open position to allow external access to the port.
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公开(公告)号：US10422753B2
公开(公告)日：2019-09-24
申请号：US15557908
申请日：2016-03-10
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Phillip A. Bolea , Giuseppe M. Bommarito , Michele A. Waldner , Thomas J. Brace , Stephen R. Alexander , Thomas E. Dewey, Jr.
IPC: G01N21/76 , G01J1/42 , G01N21/03 , G01J1/02 , C12Q1/00 , C12Q1/66 , G01N33/573 , G01N33/68 , G01J1/04 , G01J1/08 , G01J3/42 , G01N21/94
Abstract: Various embodiments of a light detection device and a system that utilizes such device are disclosed. In one or more embodiments, the light detection device can include a housing that includes a port disposed in a top surface, a receptacle disposed within the housing and adapted to receive a sample, a detector disposed within the housing along an optical axis and including an input surface having an active area, and a reflector disposed within the housing along the optical axis between the receptacle and the input surface of the detector. The reflector can include an input aperture disposed adjacent the receptacle, an output aperture disposed adjacent the input surface of the detector, and a reflective surface that extends between the input aperture and the output aperture.
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公开(公告)号：US08802429B2
公开(公告)日：2014-08-12
申请号：US13955134
申请日：2013-07-31
Applicant: 3M Innovative Properties Company
Inventor： Stephen B. Roscoe , Phillip A. Bolea , Stephanie J. Moeller
IPC: C12M1/00
CPC classification number: G01N21/643 , C12Q1/04 , C12Q1/06
Abstract: A system for detecting microorganisms in a test sample is provided that includes a fluorescently detectable product having both acidic and basic species, wherein the fluorescently detectable product is the reaction product of (a) an enzyme substrate that comprises an enzymatically hydrolysable group and a fluorescent group and (b) a test sample comprising a microorganism having an enzyme that hydrolyzes the hydrolysable group from the fluorescent group of the enzyme substrate. The fluorescently detectable product has an excitation isosbestic point Exλiso where the absorbance of the acid species is the same as the absorbance of the basic species. The system also includes a first light source having a wavelength of Exλiso for irradiating the fluorescently detectable product, The fluorescently detectable product emits light at a wavelength of Emλ1, and the quantity of light emitted at the wavelength Emλ1 is substantially constant across a pH range of 2.5 to 8.0.
Abstract translation: 提供了一种用于检测测试样品中的微生物的系统，其包括具有酸性和碱性物质的荧光检测产物，其中所述荧光检测产物是（a）包含酶可水解基团和荧光基团的酶底物的反应产物 和（b）包含具有从酶底物的荧光基团水解可水解基团的酶的微生物的测试样品。 荧光检测产物具有激发等位点Exλiso，其中酸物质的吸光度与碱性物质的吸光度相同。 该系统还包括具有用于照射荧光可检测产物的Exλiso波长的第一光源。 荧光检测产物以Emλ1的波长发光，并且在2.5至8.0的pH范围内在波长Emλ1处发射的光量基本上恒定。
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公开(公告)号：US20130316443A1
公开(公告)日：2013-11-28
申请号：US13955134
申请日：2013-07-31
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Stephen B. Roscoe , Phillip A. Bolea , Stephanie J. Moeller
IPC: G01N21/64
CPC classification number: G01N21/643 , C12Q1/04 , C12Q1/06
Abstract: A system for detecting microorganisms in a test sample is provided that includes a fluorescently detectable product having both acidic and basic species, wherein the fluorescently detectable product is the reaction product of (a) an enzyme substrate that comprises an enzymatically hydrolysable group and a fluorescent group and (b) a test sample comprising a microorganism having an enzyme that hydrolyzes the hydrolysable group from the fluorescent group of the enzyme substrate. The fluorescently detectable product has an excitation isosbestic point Exλiso where the absorbance of the acid species is the same as the absorbance of the basic species. The system also includes a first light source having a wavelength of Exλiso for irradiating the fluorescently detectable product, The fluorescently detectable product emits light at a wavelength of Emλ1, and the quantity of light emitted at the wavelength Emλ1 is substantially constant across a pH range of 2.5 to 8.0.
Abstract translation: 提供了一种用于检测测试样品中的微生物的系统，其包括具有酸性和碱性物质的荧光检测产物，其中所述荧光检测产物是（a）包含酶可水解基团和荧光基团的酶底物的反应产物 和（b）包含具有从酶底物的荧光基团水解可水解基团的酶的微生物的测试样品。 荧光检测产物具有激发等位点Exlambdaiso，其中酸物质的吸光度与碱性物质的吸光度相同。 该系统还包括具有用于照射荧光可检测产物的Exlambdaiso波长的第一光源。荧光可检测的产物发射波长为λ1的光，并且在波长λλ1处发射的光的量在pH范围内基本上恒定 2.5至8.0。
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