公开(公告)号：US20140186878A1

公开(公告)日：2014-07-03

申请号：US14008905

申请日：2012-03-05

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Stephen B. Roscoe ,  Shih-Hung Chou ,  Stephanie J. Moeller ,  Jesse D. Miller ,  Kurt J. Halverson ,  Jason W. Bjork

IPC: C12Q1/04 ,  C07H17/075 ,  C07D409/04 ,  C07D311/16 ,  C07D405/04

CPC classification number: C12Q1/04 ,  C07D311/16 ,  C07D405/04 ,  C07D409/04 ,  C07H17/075 ,  C09B57/02 ,  C12Q1/045 ,  G01N33/525 ,  G01N33/582

Abstract: Compounds are provided that are either fluorogenic or fluorophoric. Compositions and articles that include the compounds are also provided. Additionally, methods of detecting a microorganism using the compounds are provided. The compounds are fluorinated and can be used advantageously under acidic conditions.

Abstract translation: 提供了荧光或荧光的化合物。 还提供了包含化合物的组合物和制品。 另外，提供使用该化合物检测微生物的方法。 化合物是氟化的，并且可以在酸性条件下有利地使用。

公开(公告)号：US10772767B2

公开(公告)日：2020-09-15

申请号：US14899608

申请日：2014-06-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jason W. Bjork ,  Kurt J. Halverson ,  Alexi J. Young ,  Stephanie J. Moeller

IPC: A61F13/00 ,  A61L15/32 ,  A61F13/02 ,  A61L15/44 ,  A61L15/42 ,  A61L15/58

Abstract: A fibrin-coated wound dressing article having a flexible film layer, a pressure-sensitive adhesive layer disposed on the flexible film layer, and a fibrin powder layer disposed on a surface of the pressure-sensitive adhesive layer opposite the flexible film layer. Methods of making and using fibrin-coated wound dressing articles are included.

公开(公告)号：US20160143786A1

公开(公告)日：2016-05-26

申请号：US14899608

申请日：2014-06-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jason W. Bjork ,  Kurt J. Halverson ,  Alexi J. Young ,  Stephanie J. Moeller

IPC: A61F13/00 ,  A61L15/42 ,  A61L15/58 ,  A61F13/02 ,  A61L15/32

Abstract: A fibrin-coated wound dressing article having a flexible film layer, a pressure-sensitive adhesive layer disposed on the flexible film layer, and a fibrin powder layer disposed on a surface of the pressure-sensitive adhesive layer opposite the flexible film layer. Methods of making and using fibrin-coated wound dressing articles are included.

Abstract translation: 具有柔性膜层的纤维蛋白涂覆伤口敷料制品，设置在柔性膜层上的压敏粘合剂层以及设置在与柔性膜层相对的压敏粘合剂层的表面上的纤维蛋白粉末层。 包括制造和使用纤维蛋白涂层伤口敷料制品的方法。

公开(公告)号：US09896711B2

公开(公告)日：2018-02-20

申请号：US15226096

申请日：2016-08-02

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Stephen B. Roscoe ,  Shih-Hung Chou ,  Stephanie J. Moeller ,  Jesse D. Miller ,  Kurt J. Halverson ,  Jason W. Bjork

IPC: C07D405/04 ,  C12Q1/04 ,  C07D311/16 ,  C07D409/04 ,  C07H17/075 ,  G01N33/52 ,  G01N33/58 ,  C09B57/02

CPC classification number: C12Q1/04 ,  C07D311/16 ,  C07D405/04 ,  C07D409/04 ,  C07H17/075 ,  C09B57/02 ,  C12Q1/045 ,  G01N33/525 ,  G01N33/582

Abstract: Compounds are provided that are either fluorogenic or fluorophoric. Compositions and articles that include the compounds are also provided. Additionally, methods of detecting a microorganism using the compounds are provided. The compounds are fluorinated and can be used advantageously under acidic conditions.

公开(公告)号：US08936916B2

公开(公告)日：2015-01-20

申请号：US13932507

申请日：2013-07-01

Applicant: 3M Innovative Properties Company

Inventor： Stephen B. Roscoe ,  Stephanie J. Moeller ,  Yi He ,  Richard B. Ross

IPC: G01N33/53 ,  G01N33/569 ,  C07K7/08

CPC classification number: G01N33/56961 ,  C07K7/08 ,  G01N2469/10

Abstract: Polypeptides which can be activated to cause the formation of pores in a lipid membrane are disclosed. Also disclosed are polypeptide compositions for the detection of target microorganisms and methods of using said compositions.

Abstract translation: 公开了可以被活化以在脂质膜中形成孔的多肽。 还公开了用于检测靶微生物的多肽组合物和使用所述组合物的方法。

公开(公告)号：US08802429B2

公开(公告)日：2014-08-12

申请号：US13955134

申请日：2013-07-31

Applicant: 3M Innovative Properties Company

Inventor： Stephen B. Roscoe ,  Phillip A. Bolea ,  Stephanie J. Moeller

IPC: C12M1/00

CPC classification number: G01N21/643 ,  C12Q1/04 ,  C12Q1/06

Abstract: A system for detecting microorganisms in a test sample is provided that includes a fluorescently detectable product having both acidic and basic species, wherein the fluorescently detectable product is the reaction product of (a) an enzyme substrate that comprises an enzymatically hydrolysable group and a fluorescent group and (b) a test sample comprising a microorganism having an enzyme that hydrolyzes the hydrolysable group from the fluorescent group of the enzyme substrate. The fluorescently detectable product has an excitation isosbestic point Exλiso where the absorbance of the acid species is the same as the absorbance of the basic species. The system also includes a first light source having a wavelength of Exλiso for irradiating the fluorescently detectable product, The fluorescently detectable product emits light at a wavelength of Emλ1, and the quantity of light emitted at the wavelength Emλ1 is substantially constant across a pH range of 2.5 to 8.0.

Abstract translation: 提供了一种用于检测测试样品中的微生物的系统，其包括具有酸性和碱性物质的荧光检测产物，其中所述荧光检测产物是（a）包含酶可水解基团和荧光基团的酶底物的反应产物 和（b）包含具有从酶底物的荧光基团水解可水解基团的酶的微生物的测试样品。 荧光检测产物具有激发等位点Exλiso，其中酸物质的吸光度与碱性物质的吸光度相同。 该系统还包括具有用于照射荧光可检测产物的Exλiso波长的第一光源。 荧光检测产物以Emλ1的波长发光，并且在2.5至8.0的pH范围内在波长Emλ1处发射的光量基本上恒定。

公开(公告)号：US20130316443A1

公开(公告)日：2013-11-28

申请号：US13955134

申请日：2013-07-31

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Stephen B. Roscoe ,  Phillip A. Bolea ,  Stephanie J. Moeller

IPC: G01N21/64

CPC classification number: G01N21/643 ,  C12Q1/04 ,  C12Q1/06

Abstract: A system for detecting microorganisms in a test sample is provided that includes a fluorescently detectable product having both acidic and basic species, wherein the fluorescently detectable product is the reaction product of (a) an enzyme substrate that comprises an enzymatically hydrolysable group and a fluorescent group and (b) a test sample comprising a microorganism having an enzyme that hydrolyzes the hydrolysable group from the fluorescent group of the enzyme substrate. The fluorescently detectable product has an excitation isosbestic point Exλiso where the absorbance of the acid species is the same as the absorbance of the basic species. The system also includes a first light source having a wavelength of Exλiso for irradiating the fluorescently detectable product, The fluorescently detectable product emits light at a wavelength of Emλ1, and the quantity of light emitted at the wavelength Emλ1 is substantially constant across a pH range of 2.5 to 8.0.

Abstract translation: 提供了一种用于检测测试样品中的微生物的系统，其包括具有酸性和碱性物质的荧光检测产物，其中所述荧光检测产物是（a）包含酶可水解基团和荧光基团的酶底物的反应产物 和（b）包含具有从酶底物的荧光基团水解可水解基团的酶的微生物的测试样品。 荧光检测产物具有激发等位点Exlambdaiso，其中酸物质的吸光度与碱性物质的吸光度相同。 该系统还包括具有用于照射荧光可检测产物的Exlambdaiso波长的第一光源。荧光可检测的产物发射波长为λ1的光，并且在波长λλ1处发射的光的量在pH范围内基本上恒定 2.5至8.0。