公开(公告)号：US20170058027A1

公开(公告)日：2017-03-02

申请号：US15156261

申请日：2016-05-16

Applicant: AbbVie Inc.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: C07K16/24

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-1α和IL-1β的蛋白质及其在用于治疗，预防和诊断IL-1相关病症并用于检测细胞，组织，样品中的IL-1α和IL-1β的组合物和方法中的用途， 和组合物。

公开(公告)号：US20230112863A1

公开(公告)日：2023-04-13

申请号：US17733303

申请日：2022-04-29

Applicant: AbbVie Inc.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: C07K16/24 ,  C07K14/545 ,  A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  G01N33/68 ,  A61K9/00

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

公开(公告)号：US20140099671A1

公开(公告)日：2014-04-10

申请号：US14104991

申请日：2013-12-12

Applicant: ABBVIE, INC.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: C07K16/24

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

公开(公告)号：US20190389945A1

公开(公告)日：2019-12-26

申请号：US16265614

申请日：2019-02-01

Applicant: AbbVie Inc.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: C07K16/24 ,  C07K14/545 ,  A61K39/395 ,  A61K45/06 ,  G01N33/68 ,  A61K9/00

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

公开(公告)号：US20130195754A1

公开(公告)日：2013-08-01

申请号：US13847862

申请日：2013-03-20

Applicant: ABBVIE INC.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: A61K39/395 ,  A61K47/48 ,  A61K45/06 ,  G01N33/68

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-1α和IL-1β的蛋白质以及它们在用于治疗，预防和诊断IL-1相关病症并用于检测细胞，组织，样品中的IL-1α和IL-1β的组合物和方法中的用途， 和组合物。

公开(公告)号：US20160272703A1

公开(公告)日：2016-09-22

申请号：US15044059

申请日：2016-02-15

Applicant: AbbVie Inc.

Inventor： Chung-ming HSIEH ,  Carrie GOODREAU ,  Tariq GHAYUR ,  Achim MOELLER ,  Sahana BOSE

IPC: C07K16/24 ,  A61K49/00 ,  G01N33/68 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48 ,  A61K51/10

CPC classification number: C07K16/241 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K49/0058 ,  A61K51/1021 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N33/6863

Abstract: TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A binding protein can be a full-length antibody or a TNF-α-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-α binding proteins are useful for detecting TNF-α and for inhibiting TNF-α activity, including in a human subject suffering from a disease or disorder in which TNF-α activity is detrimental.

公开(公告)号：US20150111251A1

公开(公告)日：2015-04-23

申请号：US14496843

申请日：2014-09-25

Applicant: AbbVie Inc.

Inventor： Chung-ming HSIEH ,  Carrie GOODREAU ,  Tariq GHAYUR ,  Achim MOELLER ,  Sahana BOSE

IPC: C07K16/24

CPC classification number: C07K16/241 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K49/0058 ,  A61K51/1021 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N33/6863

Abstract: TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A binding protein can be a full-length antibody or a TNF-α-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-α binding proteins are useful for detecting TNF-α and for inhibiting TNF-α activity, including in a human subject suffering from a disease or disorder in which TNF-α activity is detrimental.

Abstract translation: 提供TNF-α结合蛋白，包括结合TNF-α的嵌合，CDR移植和人源化抗体。 结合蛋白对TNF-α具有高亲和力，并中和TNF-α活性。 结合蛋白可以是全长抗体或其TNF-α结合部分。 还描述了制备方法和使用结合蛋白的方法。 TNF-α结合蛋白可用于检测TNF-α和抑制TNF-α活性，包括在患有TNF-α活性有害的疾病或病症的人类受试者中。

公开(公告)号：US20140220020A1

公开(公告)日：2014-08-07

申请号：US14141317

申请日：2013-12-26

Applicant: AbbVie, Inc.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: C07K16/24 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

公开(公告)号：US20140212925A1

公开(公告)日：2014-07-31

申请号：US14109606

申请日：2013-12-17

Applicant: AbbVie, Inc.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: C07K16/24

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

公开(公告)号：US20140212379A1

公开(公告)日：2014-07-31

申请号：US14107988

申请日：2013-12-16

Applicant: AbbVie, Inc.

Inventor： Chengbin WU ,  Dominic J. AMBROSI ,  Chung-ming HSIEH ,  Tariq GHAYUR

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/412 ,  Y02A50/463 ,  Y02A50/478 ,  Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

Abstract translation: 结合IL-1α和IL-1和bgr的蛋白质 描述其用于治疗，预防和诊断IL-1相关疾病和用于检测IL-1α和IL-1和bgr的组合物和方法中的用途; 在细胞，组织，样品和组合物中。