Patent search ap:("ABBVIE INC.") AND inv:"Tariq GHAYUR" Page 1

1.

发明申请
IL-1 BINDING PROTEINS 审中-公开
Title translation: IL-1结合蛋白

公开(公告)号：US20170058027A1

公开(公告)日：2017-03-02

申请号：US15156261

申请日：2016-05-16

Applicant: AbbVie Inc.

Inventor： Chengbin WU , Dominic J. AMBROSI , Chung-ming HSIEH , Tariq GHAYUR

IPC: C07K16/24

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-1α和IL-1β的蛋白质及其在用于治疗，预防和诊断IL-1相关病症并用于检测细胞，组织，样品中的IL-1α和IL-1β的组合物和方法中的用途，和组合物。

2.

发明申请
IL-1 Binding Proteins 审中-公开

公开(公告)号：US20190389945A1

公开(公告)日：2019-12-26

申请号：US16265614

申请日：2019-02-01

Applicant: AbbVie Inc.

Inventor： Chengbin WU , Dominic J. AMBROSI , Chung-ming HSIEH , Tariq GHAYUR

IPC: C07K16/24 , C07K14/545 , A61K39/395 , A61K45/06 , G01N33/68 , A61K9/00

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

3.

发明申请
Dual Variable Domain Immunoglobulin and Uses Thereof 审中-公开

公开(公告)号：US20150147327A1

公开(公告)日：2015-05-28

申请号：US14551792

申请日：2014-11-24

Applicant: ABBVIE INC.

Inventor： Chengbin WU , Tariq GHAYUR , Richard W. DIXON , Jochen G. SALFELD

IPC: C07K16/46 , C07K16/24

CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

4.

发明申请
Dual Variable Domain Immunoglobulin and Uses Thereof 审中-公开
Title translation: 双可变域免疫球蛋白及其用途

公开(公告)号：US20150086554A1

公开(公告)日：2015-03-26

申请号：US14524479

申请日：2014-10-27

Applicant: AbbVie Inc.

Inventor： Chengbin WU , Tariq GHAYUR , Richard W. DIXON , Jochen G. SALFELD

IPC: C07K16/46 , C07K16/28 , C07K16/24

CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。

5.

发明申请
MONOVALENT BINDING PROTEINS 有权
Title translation: 单价结合蛋白

公开(公告)号：US20140221622A1

公开(公告)日：2014-08-07

申请号：US14141503

申请日：2013-12-27

Applicant: ABBVIE, INC.

Inventor： Tariq GHAYUR , Jijie GU

IPC: C07K16/00

CPC classification number: C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/468 , C07K2317/35 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94

Abstract: Engineered monovalent binding proteins that bind to one or more ligands (such as an antigen) via one binding domain are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.

Abstract translation: 提供了通过一个结合结构域结合一个或多个配体（例如抗原）的工程化单价结合蛋白，以及制备和用于预防，诊断和/或治疗疾病的方法。

6.

发明申请
IL-l BINDING PROTEINS 有权
Title translation: IL-1结合蛋白

公开(公告)号：US20130195754A1

公开(公告)日：2013-08-01

申请号：US13847862

申请日：2013-03-20

Applicant: ABBVIE INC.

Inventor： Chengbin WU , Dominic J. AMBROSI , Chung-ming HSIEH , Tariq GHAYUR

IPC: A61K39/395 , A61K47/48 , A61K45/06 , G01N33/68

CPC classification number: C07K16/245 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K9/007 , A61K9/0085 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K47/6879 , C07K14/545 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , G01N2800/00 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/412 , Y02A50/463 , Y02A50/478 , Y02A50/481

Abstract: Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-1α和IL-1β的蛋白质以及它们在用于治疗，预防和诊断IL-1相关病症并用于检测细胞，组织，样品中的IL-1α和IL-1β的组合物和方法中的用途，和组合物。

7.

发明申请
Dual Variable Domain Immunoglobulins and Uses Thereof 审中-公开

公开(公告)号：US20170226200A1

公开(公告)日：2017-08-10

申请号：US15270945

申请日：2016-09-20

Applicant: AbbVie, Inc.

Inventor： Tariq GHAYUR , Junjian Liu , Peter C. Isakson

IPC: C07K16/24 , G01N33/68 , A61K45/06 , C07K16/46 , A61K39/395

CPC classification number: C07K16/244 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K49/00 , A61K51/1021 , A61K2039/505 , C07K16/241 , C07K16/245 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/53 , G01N33/56966 , G01N33/6857 , G01N33/6863 , G01N33/6869 , G01N2333/525 , G01N2333/54 , G01N2333/545 , G01N2800/24 , G01N2800/7028

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.

8.

发明申请
BINDING PROTEINS AGAINST VEGF, PDGF, AND/OR THEIR RECEPTORS 有权
Title translation: 结合VEGF，PDGF和/或其受体的结合蛋白

公开(公告)号：US20170015742A1

公开(公告)日：2017-01-19

申请号：US15183725

申请日：2016-06-15

Applicant: ABBVIE INC.

Inventor： Jijie GU , Diana BOWLEY , Lucia EATON , Feng DONG , Lorenzo BENATUIL , Tariq GHAYUR , Ravi CHARI , Matthew RIESER , Anca CLABBERS

IPC: C07K16/22 , A61K39/395 , C07K16/46 , A61K45/06

CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/00 , C07K16/24 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94

Abstract: Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding fragments, fusion proteins, and bispecific or multispecific proteins thereof are disclosed. Also disclosed are methods of making and using the binding proteins.

Abstract translation: 公开了结合一种或多种VEGF，PDGF和/或其受体的结合蛋白，包括抗体，CDR-移植的抗体，人源化抗体，结合片段，融合蛋白和双特异性或多特异性蛋白。还公开了制备和使用结合蛋白的方法。