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公开(公告)号：US20170210796A1
公开(公告)日：2017-07-27
申请号：US15343327
申请日：2016-11-04
Applicant: AbbVie, Inc.
Inventor： Michael SIEDLER , Vineet KUMAR , Ravi CHARI , Sonal SALUJA , Vishwesh PATIL
IPC: C07K16/24 , C07K16/18 , C07K16/22 , A61K39/395 , A61K47/22 , A61K47/10 , A61K47/26 , A61K9/08 , C07K16/26 , A61K9/19
CPC classification number: C07K16/245 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K39/39591 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/247 , C07K16/26 , C07K16/2827 , C07K16/2875 , C07K16/2887 , C07K16/32 , C07K16/4291 , C07K2317/31 , C07K2317/56 , C07K2317/60 , C07K2317/94
Abstract: The invention provides stable aqueous formulations comprising an Aqueous Stable Dual Variable Domain Immunoglobulin (AS-DVD-Ig) protein. The invention also provides stable lyophilized formulations comprising a Lyophilized Stable Dual Variable Domain Immunoglobulin (LS-DVD-Ig) protein.
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公开(公告)号：US20170015742A1
公开(公告)日：2017-01-19
申请号：US15183725
申请日：2016-06-15
Applicant: ABBVIE INC.
Inventor： Jijie GU , Diana BOWLEY , Lucia EATON , Feng DONG , Lorenzo BENATUIL , Tariq GHAYUR , Ravi CHARI , Matthew RIESER , Anca CLABBERS
IPC: C07K16/22 , A61K39/395 , C07K16/46 , A61K45/06
CPC classification number: C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/00 , C07K16/24 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Binding proteins that bind one or more of VEGF, PDGF and/or their receptors, including antibodies, CDR-grafted antibodies, humanized antibodies, binding fragments, fusion proteins, and bispecific or multispecific proteins thereof are disclosed. Also disclosed are methods of making and using the binding proteins.
Abstract translation: 公开了结合一种或多种VEGF，PDGF和/或其受体的结合蛋白，包括抗体，CDR-移植的抗体，人源化抗体，结合片段，融合蛋白和双特异性或多特异性蛋白。 还公开了制备和使用结合蛋白的方法。
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