公开(公告)号：US20180025108A1

公开(公告)日：2018-01-25

申请号：US15670478

申请日：2017-08-07

Applicant: ACADEMIA SINICA

Inventor： An-Suei YANG ,  Hung-Pin PENG ,  Jhih-Wei JIAN

IPC: G06F19/12 ,  G06F19/24

CPC classification number: G16B5/00 ,  G16B40/00 ,  G16B50/00

Abstract: In a general aspect, a method for inferring one or more biomolecule-to-biomolecule interaction sites includes receiving data representative of a plurality of prediction models. Each prediction model is associated with a different atom type of a plurality of atom types and characterizes biomolecule-to-biomolecule interaction site specific patterns common to a plurality of three dimensional probability density maps. Each three dimensional probability density map is associated with a corresponding biomolecule of a plurality of biomolecules included in a training data set and represents a probability of a non-covalent interacting atom on a surface of the corresponding biomolecule interacting with the atom type associated with the prediction model. Data representative of a query biomolecule is received, the data including one or more unknown biomolecule-to-biomolecule interaction sites. The one or more unknown biomolecule-to-biomolecule interaction sites of the query biomolecule are inferred based on the data representative of the plurality of prediction models.

公开(公告)号：US20190040151A1

公开(公告)日：2019-02-07

申请号：US16166220

申请日：2018-10-22

Applicant: Academia Sinica

Inventor： An-Suei YANG ,  Wei-Ying KUO ,  Hung-Ju HSU ,  Hong-Sen CHEN ,  Yu-Chi CHOU ,  Yueh-Liang TSOU ,  Hung-Pin PENG ,  Jhih-Wei JIAN ,  Chung-Ming YU ,  Yi-Kai CHIU ,  Ing-Chein CHEN ,  Chao-Ping TUNG ,  Michael HSIAO ,  Hwei-Jiung WANG

IPC: C07K16/30 ,  A61K47/68 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K16/3015 ,  A61K39/39558 ,  A61K47/6829 ,  A61K47/6855 ,  A61K47/6889 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/32 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: Disclosed herein is an immunoconjugate comprising an antibody, a functional motif, and a linker connecting the functional motif to the antibody. According to embodiments of the present disclosure, the antibody may recognize tumor-associated antigens (TAAs), and serves as a targeting module for delivering the functional motif connected therewith to the tumor cells thereby inhibiting tumor growth or detecting the distribution of tumor cells. Also disclosed herein are methods of treating cancers and methods of diagnosing cancers by use of the present immunoconjugate.