公开(公告)号：US12116407B2

公开(公告)日：2024-10-15

申请号：US17269991

申请日：2019-09-25

Applicant: Academia Sinica

Inventor： Shie-Liang Hsieh ,  Pei-Shan Sung ,  Ming-Ting Huang ,  An-Suei Yang ,  Chung-Ming Yu

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28 ,  A61P31/20

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61P31/20 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/77

Abstract: Provided herein is a method for treating neurodegenerative diseases, such as Alzheimer's disease (AD), by use of monoclonal antibody, which exhibits a binding affinity to Siglec-3 receptor. According to some embodiments of the present disclosure, the monoclonal antibody is capable of enhancing phagocytosis of neurotoxic peptides by immune cells thereby providing a neuroprotective effect to a subject in need thereof.

公开(公告)号：US20150369806A1

公开(公告)日：2015-12-24

申请号：US14742305

申请日：2015-06-17

Applicant: National Chung Hsing University ,  Academia Sinica

Inventor： GOU-JEN WANG ,  Shie-Liang Hsieh ,  Yen-Ting Tung

IPC: G01N33/569 ,  G01N33/543 ,  C25D3/48 ,  C23C14/34 ,  C23C14/18 ,  G01N33/553 ,  G01N27/12

CPC classification number: G01N33/56983 ,  C23C14/18 ,  C23C14/34 ,  C25D11/04 ,  C25D11/24 ,  G01N27/026 ,  G01N27/127 ,  G01N33/54346 ,  G01N33/54366 ,  Y02A50/53 ,  Y02A50/60

Abstract: A sensor for detecting molecular interactions between a target and a binding domain by electrochemical impedance spectroscopy. The sensor includes an anodic aluminum oxide barrier layer having a gold-coated array of regularly spaced nano-hemispheres and gold nanoparticles coated with a binding domain attached thereto. Also provided are methods for producing the sensor and for using the sensor to detect the presence of a virus in a sample.

Abstract translation: 用于通过电化学阻抗光谱法检测靶和结合结构域之间的分子相互作用的传感器。 传感器包括阳极氧化铝阻挡层，其具有规则间隔的纳米半球的金涂层阵列和涂覆有附着于其上的结合结构域的金纳米颗粒。 还提供了用于产生传感器和使用传感器来检测样品中病毒的存在的方法。

公开(公告)号：US12103969B2

公开(公告)日：2024-10-01

申请号：US17266092

申请日：2018-09-25

Applicant: Academia Sinica

Inventor： Shie-Liang Hsieh ,  Tsung-Yu Tsai ,  An-Suei Yang ,  Chung-Ming Yu ,  Cheng-Yuan Peng

IPC: C07K16/28 ,  A61P25/28 ,  A61P31/20 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61P31/20 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/77

Abstract: Disclosed herein is a novel monoclonal antibody exhibiting binding affinity to Siglec-3 receptor. According to the embodiment, the monoclonal antibody is capable of reversing HBV-induced immunosuppression. Accordingly, also disclosed herein are the uses thereof in the treatment and/or prophylaxis of hepatitis B virus (HBV) infection.

公开(公告)号：US11142795B2

公开(公告)日：2021-10-12

申请号：US16491163

申请日：2018-03-15

Applicant: Academia Sinica

Inventor： Shie-Liang Hsieh ,  Ya-Lang Huang ,  Tsung-Yu Tsai

IPC: G01N33/53 ,  A61K38/21 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N33/566 ,  G01N33/576

Abstract: Disclosed herein is a novel use of C-type lectin 18 (CLEC18) in disease prognosis. According to embodiments of the present disclosure, the mRNA or protein level of CLEC18 may serve as an indicator for diagnosing hepatitis B virus (HBV) infection, hepatitis B e antigen (HBeAg) loss and seroconversion, and/or liver fibrosis.

公开(公告)号：US10172919B2

公开(公告)日：2019-01-08

申请号：US15537051

申请日：2015-12-29

Applicant: ACADEMIA SINICA

Inventor： Shie-Liang Hsieh ,  Yung-Chi Chang ,  Ming-Ting Huang

IPC: A61K39/00 ,  A61K38/17 ,  C07K14/705

Abstract: Disclosed herein is a method of treating influenza A virus (IAV) infection by a fusion protein. According to some embodiments of the present disclosure, the fusion protein comprises a HBD peptide and a IgG1 Fc region. According to other embodiments of the present disclosure, the fusion protein comprises a DcR3 protein and a IgG1 Fc region. The present fusion protein is found to possess inhibitory effects on IAV-induced secretion of the inflammatory cytokine, and IAV-induced infiltration of inflammatory cell into the lung tissue. Accordingly, the fusion protein is useful for developing a medicament for the treatment or prophylaxis of IAV infection and/or ameliorating pulmonary injury caused by excessive inflammation associated with IAV infection in a subject.

公开(公告)号：US10011646B2

公开(公告)日：2018-07-03

申请号：US15239971

申请日：2016-08-18

Applicant: Academia Sinica

Inventor： Shie-Liang Hsieh ,  Henrich Cheng ,  Wen-Hung Huang ,  Chuan-Wen Chiu ,  Shao-Ji Lin

IPC: A61K38/17 ,  A61K39/395 ,  C07K14/705 ,  A61K9/00

CPC classification number: C07K14/70578 ,  A61K9/0019 ,  A61K9/0085 ,  A61K38/1793 ,  A61K39/3955 ,  C07K2319/30

Abstract: Disclosed herein are methods for treating spinal cord injury using recombinant decoy receptor 3 (DcR3) polypeptide. Also disclosed herein are methods for improving the locomotor function recovery of a spinal cord injured subject with a DcR3 polypeptide.

公开(公告)号：US20170051038A1

公开(公告)日：2017-02-23

申请号：US15239971

申请日：2016-08-18

Applicant: Academia Sinica

Inventor： Shie-Liang Hsieh ,  Henrich Cheng ,  Wen-Hung Huang ,  Chuan-Wen Chiu ,  Shao-Ji Lin

IPC: C07K14/705 ,  A61K9/00 ,  A61K38/17

CPC classification number: C07K14/70578 ,  A61K9/0019 ,  A61K9/0085 ,  A61K38/1793 ,  A61K39/3955 ,  C07K2319/30

Abstract: Disclosed herein are methods for treating spinal cord injury using recombinant decoy receptor 3 (DcR3) polypeptide. Also disclosed herein are methods for improving the locomotor function recovery of a spinal cord injured subject with a DcR3 polypeptide.

Abstract translation: 本文公开了使用重组诱饵受体3（DcR3）多肽治疗脊髓损伤的方法。 本文还公开了用于用DcR3多肽改善脊髓损伤受试者的运动功能恢复的方法。