公开(公告)号：US10034848B2

公开(公告)日：2018-07-31

申请号：US14925007

申请日：2015-10-28

Applicant: Academia Sinica

Inventor： Yi-Ping Hsueh

IPC: A61K31/00 ,  A61K31/198

CPC classification number: A61K31/198 ,  A61K31/00

Abstract: Disclosed herein is a method for increasing the dendritic spine formation or dendritic spine density in a subject, who is affected by a dendritic spine defect caused by the impairment in neurofibromin (NF1 protein), valosin-containing protein (VCP), atlastin-1 (ATL1), or superoxide dismutase 1 (SOD1). Accordingly, also disclosed herein is a method for treating a subject having or suspected of having a synaptopathy caused by the impairment in NF1, VCP, ATL1, or SOD1.

公开(公告)号：US12059433B2

公开(公告)日：2024-08-13

申请号：US17077504

申请日：2020-10-22

Applicant: ACADEMIA SINICA

Inventor： Yi-Ping Hsueh ,  Tzyy-Nan Huang

IPC: A61K31/198 ,  A01K67/0276 ,  A01K67/0278 ,  A23K20/142 ,  A23K20/20 ,  A23L33/16 ,  A23L33/175 ,  A61K9/00 ,  A61K9/68 ,  A61K33/30 ,  A61K49/00 ,  A61P25/00 ,  G01N33/68

CPC classification number: A61K33/30 ,  A01K67/0276 ,  A01K67/0278 ,  A23K20/142 ,  A23K20/30 ,  A23L33/16 ,  A23L33/175 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/0095 ,  A61K31/198 ,  A61K49/0008 ,  A61P25/00 ,  G01N33/6806 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  A23V2002/00

Abstract: The present invention relates to a method for treating autism spectrum disorders (ASD) or ASD-like symptom, particularly by administering a zinc ion source and/or a serine component e.g. D-serine or its precursor/analogue, optionally in combination with a mixture of branched-chain amino acids (BCAAs). The present invention also relates to a combination, kit or composition for performing the method for treatment as described herein. Further described is use of a zinc ion source and/or a serine component and optional BCAAs for manufacturing a medicament for treating a symptom or disease characteristics associated with ASD or ASD-associated disorder or as a food supplement for ameliorating relevant symptoms in a subject in need thereof. The present invention further provides an animal model for autistic spectrum disorder (ASD) with deficient CTTNBP2 gene, and a method for identifying an ingredient effective in the treatment of ASD by using such animal model.

公开(公告)号：US20210113610A1

公开(公告)日：2021-04-22

申请号：US17077504

申请日：2020-10-22

Applicant: ACADEMIA SINICA

Inventor： Yi-Ping Hsueh ,  Tzyy-Nan Huang

IPC: A61K33/30 ,  A61K31/198 ,  A61K9/00 ,  A61K9/68 ,  A61P25/00 ,  G01N33/68 ,  A01K67/027 ,  A61K49/00 ,  A23L33/16 ,  A23L33/175 ,  A23K20/142 ,  A23K20/20

Abstract: The present invention relates to a method for treating autism spectrum disorders (ASD) or ASD-like symptom, particularly by administering a zinc ion source and/or a serine component e.g. D-serine or its precursor/analogue, optionally in combination with a mixture of branched-chain amino acids (BCAAs). The present invention also relates to a combination, kit or composition for performing the method for treatment as described herein. Further described is use of a zinc ion source and/or a serine component and optional BCAAs for manufacturing a medicament for treating a symptom or disease characteristics associated with ASD or ASD-associated disorder or as a food supplement for ameliorating relevant symptoms in a subject in need thereof. The present invention further provides an animal model for autistic spectrum disorder (ASD) with deficient CTTNBP2 gene, and a method for identifying an ingredient effective in the treatment of ASD by using such animal model.