公开(公告)号：US20210382325A1

公开(公告)日：2021-12-09

申请号：US17304691

申请日：2021-06-24

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Nabin JOSHI ,  Arkady SELENOW ,  Steve ALI ,  Stefan BAUER ,  Jean-Noël FEHR ,  Moritz HAEBERLI ,  Patrizia WEBER ,  Julien SAUVET ,  Amitava GUPTA

IPC: G02C7/06 ,  G02C11/04 ,  G02C7/02

Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US20220155616A1

公开(公告)日：2022-05-19

申请号：US17650134

申请日：2022-02-07

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Nabin JOSHI ,  Arkady SELENOW ,  Steven ALI ,  Stefan BAUER ,  Jean-Noël FEHR ,  Moritz HAEBERLI ,  Patrizia WEBER ,  Julien SAUVET ,  Amitava GUPTA

IPC: G02C7/02 ,  G02C7/06 ,  G02C11/04 ,  A61F9/00 ,  G02C7/04 ,  A61B3/00

Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US20230144121A1

公开(公告)日：2023-05-11

申请号：US18153000

申请日：2023-01-11

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNHARD ,  Jean-Noel FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

IPC: A61N5/06 ,  G02B27/30 ,  G02B27/01

CPC classification number: A61N5/0622 ,  G02B27/30 ,  G02B27/0172 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0652 ,  A61N2005/0663 ,  G02B2027/0178

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US20220257972A1

公开(公告)日：2022-08-18

申请号：US17662098

申请日：2022-05-05

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNHARD ,  Jean-Noël FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

IPC: A61N5/06 ,  G02B27/30 ,  G02B27/01

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US20240252835A1

公开(公告)日：2024-08-01

申请号：US18632487

申请日：2024-04-11

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNHARD ,  Jean-Noel FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

IPC: A61N5/06 ,  G02B27/01 ,  G02B27/30

CPC classification number: A61N5/0622 ,  G02B27/0172 ,  G02B27/30 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0652 ,  A61N2005/0663 ,  G02B2027/0178

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US20220413318A1

公开(公告)日：2022-12-29

申请号：US17929852

申请日：2022-09-06

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Nabin JOSHI ,  Arkady SELENOW ,  Steven ALI ,  Stefan BAUER ,  Jean-Noel FEHR ,  Moritz HAEBERLI ,  Patrizia WEBER ,  Julien SAUVET ,  Amitava GUPTA

IPC: G02C7/02 ,  A61F9/00 ,  G02C11/04 ,  A61B3/00 ,  G02C7/04 ,  G02C7/06

Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US20210031051A1

公开(公告)日：2021-02-04

申请号：US16947537

申请日：2020-08-05

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNARD ,  Jean-Noël FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

IPC: A61N5/06 ,  G02B27/30 ,  G02B27/01

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.