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公开(公告)号:US20250064908A1
公开(公告)日:2025-02-27
申请号:US18924824
申请日:2024-10-23
Applicant: AMAZON TECHNOLOGIES, INC
Inventor: Frank Wilhelm Schmitz , David Heckerman , Layne Christopher Price , Antje Heit
Abstract: Provided herein are immunogenic compositions comprising tumor-specific neoantigen long peptides, tumor-specific neoantigen short peptides, and adjuvant, optionally a helper peptide, and optionally a tumor-specific peptide. The disclosure also provides methods of using these immunogenic compositions for treating cancer.
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公开(公告)号:US20250003004A1
公开(公告)日:2025-01-02
申请号:US18271540
申请日:2023-07-06
Applicant: AMAZON TECHNOLOGIES, INC.
Inventor: Haibao Tang , David Heckerman , Layne Christopher Price , Frank Wilhelm Schmitz , Alena Harley , Antje Heit , Samuel Anthony Danziger
IPC: C12Q1/6886 , A61K39/00
Abstract: Disclosed herein is a method, comprising administering to a subject in need thereof an initial immunogenic composition comprising a plurality of tumor-specific neoantigens, each corresponding to a member of a first set of tumor-associated mutations in a subject, and none corresponding to a member of a second set of tumor-associated mutations in the subject; and quantifying each member of the first set of tumor-associated mutations and each member of the second set of tumor-associated mutations in circulating material comprising tumor-associated mutations isolated from the subject at each of multiple time points.
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公开(公告)号:US12156716B1
公开(公告)日:2024-12-03
申请号:US17155485
申请日:2021-01-22
Applicant: AMAZON TECHNOLOGIES, INC.
Inventor: Adrian Napoles , Christopher Raymond Grajewski , Andreas Caduff , David Heckerman
Abstract: Data about concentration of one or more types of molecules present within a human body are determined noninvasively using radio frequency (RF) signals. Signals at several different frequencies at very low power levels are emitted using an antenna mounted to a wearable device. Operating values, such as changes to the impedance of the antenna resulting from interaction between the RF signals and the user, are associated with the concentration of one or more types of molecules within the user. These changes in impedance may be relatively small. Circuitry in the device determines internal impedance of the circuitry, compensating for internal impedances and improving overall accuracy of the measured impedance resulting from interaction with the user.
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公开(公告)号:US12029557B1
公开(公告)日:2024-07-09
申请号:US17116368
申请日:2020-12-09
Applicant: AMAZON TECHNOLOGIES, INC.
Inventor: Justin Christopher Kenny , Adrian Napoles , Andreas Caduff , Christopher Raymond Grajewski , David Heckerman
CPC classification number: A61B5/14546 , A61B5/053 , A61B5/6824 , H01Q1/273 , H04B1/385 , H04B17/104 , A61B5/14532 , A61B5/4845 , A61B5/4875
Abstract: Data about concentration of one or more types of molecules present within a human body are determined noninvasively using radio frequency signals. Signals at several different frequencies at very low power levels are emitted using an antenna mounted to a wearable device. The antenna includes nested elements of different sizes. Operating values, such as changes to the impedance of the antenna, are associated with the concentration of one or more types molecules within the user. Concentrations at different depths may be measured by using different sets of the nested elements at different times. Operating values at those times are measured and used to determine information indicative of concentration of the molecules. During use, a long axis of the antenna may be aligned with a long axis of a user's arm.
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公开(公告)号:US11869535B1
公开(公告)日:2024-01-09
申请号:US16711883
申请日:2019-12-12
Applicant: Amazon Technologies, Inc.
Inventor: Mohammad Taha Bahadori , Viktor Rozgic , Alexander Jonathan Pinkus , Chao Wang , David Heckerman
CPC classification number: G10L25/63 , G06N3/044 , G06N3/08 , G10L15/063 , G10L15/16 , G10L15/1815 , G10L15/22 , G10L2015/223
Abstract: Described is a system and method that determines character sequences from speech, without determining the words of the speech, and processes the character sequences to determine sentiment data indicative of emotional state of a user that output the speech. The emotional state may then be presented or provided as an output to the user.
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公开(公告)号:US20220383996A1
公开(公告)日:2022-12-01
申请号:US17332719
申请日:2021-05-27
Applicant: Amazon Technologies, Inc.
Inventor: Layne Christopher Price , David Heckerman , Frank Wilhelm Schmitz
Abstract: Techniques are described and relate to assigning peptides to peptide groups for vaccine development. In an example, a peptide property of a peptide is determined, where this peptide is from different peptides that are to be assigned to different groups of vaccine. A determination is also made that the peptide is to be assigned to a first group from the different groups based at least in part on the peptide property. The first group has a first group property that is based at least in part on peptide properties of first peptides to be assigned to the first group. The first group property is within a similarity range relative to a second group property of a second group from the different groups. Information is generated and indicates that the peptide is assigned to the first group.
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公开(公告)号:US11862037B1
公开(公告)日:2024-01-02
申请号:US16453449
申请日:2019-06-26
Applicant: Amazon Technologies, Inc.
Inventor: David Lawrence Seymore , Leo Benedict Baldwin , David Heckerman , Michael Vogelsong , Maulik Majmudar
CPC classification number: G09B19/0092 , A61B5/0205 , A61B5/14517 , A61B5/14532 , A61B5/318 , A61B5/681 , A61B5/742 , G16H20/60 , A61B5/02438 , A61B2562/0204
Abstract: Systems, devices, and methods are provided for detecting and correcting eating behavior. A device may receive audio data, determine that the audio data is indicative of consumption of a product by a user. The device may determine, based on the product, a measureable attribute associated with the user. The device may receive first data associated with the measureable attribute. The device may determine that the first data exceeds a threshold. The device may generate a message for presentation.
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公开(公告)号:US12057196B1
公开(公告)日:2024-08-06
申请号:US17209486
申请日:2021-03-23
Applicant: Amazon Technologies, Inc.
Inventor: Layne Christopher Price , David Heckerman
Abstract: Techniques are described and relate to anisotropic pooling for contextual embedding of a protein sequence. In an example, a system receives a first biological sequence and determines a sequence arrangement that comprises a component of the first biological sequence and a second biological sequence of components. By using an artificial intelligence (AI) model, the system determines a third sequence that comprises a contextual embedding vector corresponding to the component of the first biological sequence. The AI model generates the third sequence based at least in part on the sequence arrangement and by at least using a convolution and anisotropic pooling.
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公开(公告)号:US11610126B1
公开(公告)日:2023-03-21
申请号:US16447888
申请日:2019-06-20
Applicant: Amazon Technologies, Inc.
Inventor: David Heckerman , Mohammad Taha Bahadori , Zachary Chase Lipton
Abstract: Techniques for generating multiple-resolutions of time series data are described. An input irregular time series having a plurality of data points is obtained, each data point of the plurality of data points including a timestamp and a feature vector. Based on the input irregular time series, multiple variant time series are generated. A data point in one of the variant time series is based in part on a combination of at least two data points of the input irregular time series. The multiple variant time series can then be used for machine learning tasks such as training a machine learning model or using a machine learning model to infer an output.
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