公开(公告)号：US20230167130A1

公开(公告)日：2023-06-01

申请号：US17922619

申请日：2021-05-05

Applicant: AMGEN INC.

Inventor： Austin G. SMITH ,  Jason S. TEDROW ,  Gabrielle ST-PIERRE ,  Oliver Ralf THIEL ,  Liang HUANG ,  Philipp C. ROOSEN ,  John T. COLYER ,  Kyle D. BAUCOM ,  Ari ERICSON ,  Matthew G. BEAVER ,  Rahul P. SANGODKAR ,  Michael A. LOVETTE ,  Robert Ronald MILBURN ,  Alan H. CHERNEY ,  Sheng CUI

IPC: C07D513/10 ,  C07D267/16

CPC classification number: C07D513/10 ,  C07D267/16

Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.

公开(公告)号：US20230391771A1

公开(公告)日：2023-12-07

申请号：US18030685

申请日：2021-10-06

Applicant: AMGEN INC.

Inventor： Matthew G. BEAVER ,  Michael T. CORBETT ,  Yuanqing FANG ,  David D. FORD ,  Andrew T. PARSONS ,  Gabrielle ST-PIERRE ,  Reem TELMESANI

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07B2200/13 ,  C07B2200/07

Abstract: Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.

公开(公告)号：US20250122197A1

公开(公告)日：2025-04-17

申请号：US18987607

申请日：2024-12-19

Applicant: AMGEN INC.

Inventor： Matthew G. BEAVER ,  Michael T. CORBETT ,  Yuanqing FANG ,  David D. FORD ,  Andrew T. PARSONS ,  Gabrielle ST-PIERRE ,  Reem TELMESANI

IPC: C07D471/04

Abstract: Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.