公开(公告)号：US11672733B2

公开(公告)日：2023-06-13

申请号：US16629330

申请日：2018-07-11

Applicant: AMGEN INC.

Inventor： Cheng-Chieh Chou ,  Mingda Eu ,  Ren-Yo Forng ,  Wael Mismar

IPC: A61L2/07 ,  A61J1/14 ,  A61L2/20 ,  A61L2/26

CPC classification number: A61J1/1406 ,  A61L2/07 ,  A61L2/206 ,  A61L2/26 ,  A61L2202/23

Abstract: Drug delivery devices, sealing members for containers housed within such drug delivery devices, and related methods of assembly are disclosed. The drug delivery device may include a housing, a container disposed in the housing and having an interior volume, a drug disposed in the interior volume, and a septum. The container may have an opening formed in an end surface and which communicates with the interior volume. The septum may include a proximal end inserted through the opening into the interior volume of the container. Additionally, the septum may include a distal end having a flange disposed outwardly of the proximal end and contacting the end surface of the container. At least an end portion of the flange may be made of a material that is permeable to a gaseous sterilizing agent.

公开(公告)号：US20220087901A1

公开(公告)日：2022-03-24

申请号：US17425412

申请日：2020-02-12

Applicant: AMGEN INC.

Inventor： Nicholas J. Clark ,  Chia-Jung Wu ,  Mingda Eu ,  Artemio A. Alanis ,  Jennifer Lyn Sawicky ,  Monica Goss ,  Jennifer Stevenson ,  Heather N. Franey ,  Deirdre Piedmonte ,  Stephen Robert Brych

IPC: A61J1/20 ,  A61M39/00

Abstract: An approach for preparing a drug delivery device includes providing a prefilled delivery container and transferring a drug product contained in a drug container to the prefilled delivery container. The prefilled delivery container includes a container body containing a predetermined quantity of saline solution and a predetermined quantity of IV stabilizing solution (“IVSS”). The drug product is transferred to the prefilled delivery container via a delivery container adapter.

公开(公告)号：US20210361529A1

公开(公告)日：2021-11-25

申请号：US16629330

申请日：2018-07-11

Applicant: AMGEN INC.

Inventor： Cheng-Chieh Chou ,  Mingda Eu ,  Ren-Yo Forng ,  Wael Mismar

IPC: A61J1/14 ,  A61L2/07 ,  A61L2/20 ,  A61L2/26

Abstract: Drug delivery devices, sealing members for containers housed within such drug delivery devices, and related methods of assembly are disclosed. The drug delivery device may include a housing, a container disposed in the housing and having an interior volume, a drug disposed in the interior volume, and a septum. The container may have an opening formed in an end surface and which communicates with the interior volume. The septum may include a proximal end inserted through the opening into the interior volume of the container. Additionally, the septum may include a distal end having a flange disposed outwardly of the proximal end and contacting the end surface of the container. At least an end portion of the flange may be made of a material that is permeable to a gaseous sterilizing agent.

公开(公告)号：US12233026B2

公开(公告)日：2025-02-25

申请号：US18140823

申请日：2023-04-28

Applicant: AMGEN INC.

Inventor： Cheng-Chieh Chou ,  Mingda Eu ,  Ren-Yo Forng ,  Wael Mismar

IPC: A61L2/07 ,  A61J1/14 ,  A61L2/20 ,  A61L2/26

Abstract: Drug delivery devices, sealing members for containers housed within such drug delivery devices, and related methods of assembly are disclosed. The drug delivery device may include a housing, a container disposed in the housing and having an interior volume, a drug disposed in the interior volume, and a septum. The container may have an opening formed in an end surface and which communicates with the interior volume. The septum may include a proximal end inserted through the opening into the interior volume of the container. Additionally, the septum may include a distal end having a flange disposed outwardly of the proximal end and contacting the end surface of the container. At least an end portion of the flange may be made of a material that is permeable to a gaseous sterilizing agent.

公开(公告)号：US20230404850A1

公开(公告)日：2023-12-21

申请号：US18140823

申请日：2023-04-28

Applicant: AMGEN INC.

Inventor： Cheng-Chieh Chou ,  Mingda Eu ,  Ren-Yo Forng ,  Wael Mismar

IPC: A61J1/14 ,  A61L2/07 ,  A61L2/20 ,  A61L2/26

CPC classification number: A61J1/1406 ,  A61L2/07 ,  A61L2/206 ,  A61L2/26 ,  A61L2202/23

Abstract: Drug delivery devices, sealing members for containers housed within such drug delivery devices, and related methods of assembly are disclosed. The drug delivery device may include a housing, a container disposed in the housing and having an interior volume, a drug disposed in the interior volume, and a septum. The container may have an opening formed in an end surface and which communicates with the interior volume. The septum may include a proximal end inserted through the opening into the interior volume of the container. Additionally, the septum may include a distal end having a flange disposed outwardly of the proximal end and contacting the end surface of the container. At least an end portion of the flange may be made of a material that is permeable to a gaseous sterilizing agent.

公开(公告)号：US20220160972A1

公开(公告)日：2022-05-26

申请号：US17440906

申请日：2020-04-22

Applicant: AMGEN INC.

Inventor： Cheng-Chieh Chou ,  Mingda Eu ,  Ren-Yo Forng ,  Malak Guirguis ,  Olivia Alice Henderson ,  Jessica Hai Liu ,  Robert W. Swift ,  Chia-Jung Wu

IPC: A61M5/50 ,  A61M5/31 ,  A61M5/32

Abstract: A syringe sterilization verification assembly includes a syringe, a tip cap assembly, and a biological indicator (BI) member. The syringe includes a barrel having a tip. The tip cap assembly includes an insert having a skirt configured to receive the tip. And the biological indicator (BI) member has an annular portion disposed around at least a portion of the tip and disposed radially between the tip and the skirt of the insert.