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公开(公告)号:US20160053000A1
公开(公告)日:2016-02-25
申请号:US14839662
申请日:2015-08-28
Applicant: AMGEN INC.
Inventor: Shu-Chen LU , Minghan WANG
CPC classification number: C07K16/18 , A61K9/0019 , A61K9/0048 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07H21/02 , C07K14/515 , C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C12N15/09 , C12N15/11 , C12P21/02 , G01N33/53 , G01N33/74 , G01N2800/7014
Abstract: This disclosure relates to apelin antigen-binding proteins and methods of using the apelin antigen-binding proteins. The antigen-binding protein may comprise an antibody to apelin and can be used to treat pathological conditions involving angiogenesis. The pathological conditions can comprise cancer or retinopathy and/or retinopathy-related complications.
Abstract translation: 本公开涉及apelin抗原结合蛋白和使用apelin抗原结合蛋白的方法。 抗原结合蛋白可以包含对apelin的抗体,并且可以用于治疗涉及血管发生的病理状况。 病理状况可能包括癌症或视网膜病变和/或视网膜病变相关并发症。