公开(公告)号：US20140194349A1

公开(公告)日：2014-07-10

申请号：US14204892

申请日：2014-03-11

Applicant: AbbVie Inc.

Inventor： David A. DeGoey ,  Charles A. Flentge ,  William J. Flosi ,  David J. Grampovnik ,  Dale J. Kempf ,  Larry L. Klein ,  Ming C. Yeung ,  John T. Randolph ,  Xiu C. Wang ,  Su Yu

IPC: C07D213/56 ,  A61K31/443 ,  A61K45/06 ,  A61K31/426 ,  C07D401/12 ,  C07D407/12 ,  A61K31/444 ,  A61K31/4418

CPC classification number: C07D213/56 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/444 ,  A61K45/06 ,  C07C311/16 ,  C07D213/38 ,  C07D213/85 ,  C07D231/08 ,  C07D239/22 ,  C07D277/06 ,  C07D277/30 ,  C07D307/16 ,  C07D307/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/04 ,  C07D471/10 ,  C07D493/04 ,  C07F9/58 ,  C07F9/65515 ,  C07F9/65583 ,  C07K5/0207

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。

公开(公告)号：US11117927B2

公开(公告)日：2021-09-14

申请号：US16186051

申请日：2018-11-09

Applicant: AbbVie Inc.

Inventor： Ahmad Y. Sheikh ,  Alessandra Mattei ,  Xiu C. Wang

IPC: C07J63/00 ,  A61P29/00

Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.

公开(公告)号：US20140323579A1

公开(公告)日：2014-10-30

申请号：US14260532

申请日：2014-04-24

Applicant: AbbVie Inc.

Inventor： Ahmad Y. Sheikh ,  Alessandra Mattei ,  Xiu C. Wang

IPC: C07J63/00

CPC classification number: C07J63/008 ,  C07B2200/13

Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.

Abstract translation: 本发明一般涉及化合物：N - （（4aS，6aR，6bS，8aR，12aS，14aR，14bS）-11-氰基-2,2,6a，6b，9,9,12a-七甲基-10， 14-二氧代-1,2,3,4,4a，5,6,6a，6b，7,8,8a，9,10,12a，14,14a，14b-十八氢en啶-4a-基）-2,2 - 二氟丙酰胺，其多晶型物，其制备方法和用途，其药物组合物，以及试剂盒及其制备方法。

公开(公告)号：US20200062800A1

公开(公告)日：2020-02-27

申请号：US16186051

申请日：2018-11-09

Applicant: AbbVie Inc.

Inventor： Ahmad Y. Sheikh ,  Alessandra Mattei ,  Xiu C. Wang

IPC: C07J63/00 ,  A61P29/00

Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.

公开(公告)号：US09856286B2

公开(公告)日：2018-01-02

申请号：US14260532

申请日：2014-04-24

Applicant: AbbVie Inc.

Inventor： Ahmad Y. Sheikh ,  Alessandra Mattei ,  Xiu C. Wang

IPC: C07J53/00 ,  C07J63/00

CPC classification number: C07J63/008 ,  C07B2200/13

Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.

公开(公告)号：US20180094020A1

公开(公告)日：2018-04-05

申请号：US15821508

申请日：2017-11-22

Applicant: AbbVie Inc.

Inventor： Ahmad Y. Sheikh ,  Alessandra Mattei ,  Xiu C. Wang

IPC: C07J63/00

CPC classification number: C07J63/008 ,  C07B2200/13

Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.