公开(公告)号：US20140194349A1

公开(公告)日：2014-07-10

申请号：US14204892

申请日：2014-03-11

Applicant: AbbVie Inc.

Inventor： David A. DeGoey ,  Charles A. Flentge ,  William J. Flosi ,  David J. Grampovnik ,  Dale J. Kempf ,  Larry L. Klein ,  Ming C. Yeung ,  John T. Randolph ,  Xiu C. Wang ,  Su Yu

IPC: C07D213/56 ,  A61K31/443 ,  A61K45/06 ,  A61K31/426 ,  C07D401/12 ,  C07D407/12 ,  A61K31/444 ,  A61K31/4418

CPC classification number: C07D213/56 ,  A61K31/426 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/444 ,  A61K45/06 ,  C07C311/16 ,  C07D213/38 ,  C07D213/85 ,  C07D231/08 ,  C07D239/22 ,  C07D277/06 ,  C07D277/30 ,  C07D307/16 ,  C07D307/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/04 ,  C07D471/10 ,  C07D493/04 ,  C07F9/58 ,  C07F9/65515 ,  C07F9/65583 ,  C07K5/0207

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。

公开(公告)号：US09309279B2

公开(公告)日：2016-04-12

申请号：US14170199

申请日：2014-01-31

Applicant: AbbVie, Inc. ,  Enanta Pharmaceuticals, Inc.

Inventor： Yiyin Ku ,  Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  Dale J. Kempf ,  David J. Grampovnik ,  Ying Sun ,  Dong Liu ,  Yonghua Gai ,  Yat Sun Or ,  Seble H. Wagaw ,  Kenneth Engstrom ,  Tim Grieme ,  Ahmad Sheikh ,  Jianzhang Mei

IPC: C07K1/113 ,  C07D487/04

CPC classification number: C07K1/113 ,  C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

公开(公告)号：US20140148573A1

公开(公告)日：2014-05-29

申请号：US14170199

申请日：2014-01-31

Applicant: Enanta Pharmaceuticals, Inc. ,  AbbVie, Inc.

Inventor： Yiyin Ku ,  Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  Dale J. Kempf ,  David J. Grampovnik ,  Ying Sun ,  Dong Liu ,  Yonghua Gai ,  Yat Sun Or ,  Seble H. Wagaw ,  Kenneth Engstrom ,  Tim Grieme ,  Ahmad Sheikh ,  Jianzhang Mei

IPC: C07K1/113

CPC classification number: C07K1/113 ,  C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.