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1.发明授权公开(公告)号：US12114962B2
公开(公告)日：2024-10-15
申请号：US17594355
申请日：2020-04-15
Applicant: Agency for Science, Technology and Research
Inventor： Malini Olivo , Renzhe Bi , Jun Hui Ho , Yao Du
CPC classification number: A61B5/0095 , A61B5/061 , A61B5/14539 , G01S5/18 , G01S11/14 , G01S11/16
Abstract: An aspect relates to a placement device for placement in a medium, including: an elongated optical transmission guide to which a photoacoustic transducer is attached to, wherein the photoacoustic transducer may include a first surface facing away from the second end of the elongated optical transmission guide. The photoacoustic transducer may include a 3-Dimensional shape configured to produce an acoustic signal upon absorption of electromagnetic energy received from the elongated optical transmission guide, and an emission profile of the acoustic signal is based on the 3-Dimensional shape, when the photoacoustic transducer is immersed in homogeneous medium. The placement device may be integral to a medical or veterinary device. An aspect relates to a placement tracking system including the placement device and an ultrasound detector. An aspect relates to a method for tracking a portion of a placement device in a medium using the system.
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公开(公告)号：US20200163591A1
公开(公告)日：2020-05-28
申请号：US16612722
申请日：2018-05-15
Applicant: Agency for Science, Technology and Research
Inventor： Malini Olivo , Gurpreet Singh , Renzhe Bi
Abstract: Method for measuring respiratory vibration on a human or animal skin, including emitting an emission light at a first position on the skin and receiving a diffused light from the emission light at a second position on the skin; storing a vibration signal including a light intensity of the diffused light received over time; wherein the vibration signal corresponds to a mechanical vibration of the skin, and extracting a respiratory parameter from the vibration signal. In particular, at least one of the first position and the second position is in proximity to or at a trachea, a neck or a chest. The system for carrying out the method includes an emitter, a receiver, a circuit, and a processing unit. A set of a sensor module and a skin adhesive patch is also provided.
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公开(公告)号：US11635327B2
公开(公告)日：2023-04-25
申请号：US16499601
申请日：2018-03-29
Applicant: Agency for Science, Technology and Research
Inventor： Malini Olivo , Gurpreet Singh , Renzhe Bi , Kapil Dev , Dinish Unnimadhava Kurup Soudamini Amma , Chris Jun Hui Ho
Abstract: Provided is an optical probe, and a Raman spectroscopy system using such, including excitation and detection optics coupled to a sampling optics via a beam splitter, in confocal arrangement with a sample focal plane of the sampling optics. The detection optics is arranged to receive Raman signal from the sample focal plane and direct it onto a tip of a detection optical fiber. The optical probe may further include a positioning device mechanically coupled to the sampling optics and configured to control a position of the sample focal plane. In the Raman spectroscopy system a light source is coupled to the excitation optics via an excitation optical fiber, and a spectrometer is coupled to a detection optics via a detection optical fiber. Provided is further a method for measuring Raman signal depth profile in a sample, wherein sample's Raman spectra is measured and stored at different focal plane positions.
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Patent Agency Ranking
公开(公告)号：US20200205664A1
公开(公告)日：2020-07-02
申请号：US16622038
申请日：2018-07-03
Applicant: Agency for Science, Technology and Research
Inventor： Jun Hui Chris Ho , Renzhe Bi , Chi Lok Dave Wong , Malini Olivo , Tao Yang , Zhongkang Lu , Weimin Huang , Kapil Dev
Abstract: There is provided a method for multi-modal imaging of tissue. The method includes: providing a fiber probe over a target area of the tissue, the fiber probe including a plurality of source fiber channels, a plurality of detector fiber channels and a plurality of fiducial marker channels, the plurality of source fiber channels, the plurality of detector fiber channels and the plurality of fiducial marker channels having a predetermined spatial arrangement in the fiber probe; directing light through each of the plurality of source fiber channels of the fiber probe to the target area in succession for performing optical imaging of the target area; obtaining optical imaging data of the target area based on attenuated light from the target area detected through the plurality of detector fiber channels due to said light directed to the target area; obtaining MRI data of the target area based on a MRI of the target area; and coregistering the optical imaging data and the MRI data based on a plurality of fiducial features captured in the MRI data corresponding to the plurality of fiducial marker channels of the fiber probe. There is also provide a corresponding system for multi-modal imaging of tissue.
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公开(公告)号：US11419520B2
公开(公告)日：2022-08-23
申请号：US16612722
申请日：2018-05-15
Applicant: Agency for Science, Technology and Research
Inventor： Malini Olivo , Gurpreet Singh , Renzhe Bi
Abstract: Method for measuring respiratory vibration on a human or animal skin, including emitting an emission light at a first position on the skin and receiving a diffused light from the emission light at a second position on the skin; storing a vibration signal including a light intensity of the diffused light received over time; wherein the vibration signal corresponds to a mechanical vibration of the skin, and extracting a respiratory parameter from the vibration signal. In particular, at least one of the first position and the second position is in proximity to or at a trachea, a neck or a chest. The system for carrying out the method includes an emitter, a receiver, a circuit, and a processing unit. A set of a sensor module and a skin adhesive patch is also provided.
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6.发明申请公开(公告)号：US20220183563A1
公开(公告)日：2022-06-16
申请号：US17594355
申请日：2020-04-15
Applicant: Agency for Science, Technology and Research
Inventor： Malini Olivo , Renzhe Bi , Jun Hui Ho , Yao Du
Abstract: An aspect relates to a placement device for placement in a medium, including: an elongated optical transmission guide to which a photoacoustic transducer is attached to, wherein the photoacoustic transducer may include a first surface facing away from the second end of the elongated optical transmission guide. The photoacoustic transducer may include a 3-Dimensional shape configured to produce an acoustic signal upon absorption of electromagnetic energy received from the elongated optical transmission guide, and an emission profile of the acoustic signal is based on the 3-Dimensional shape, when the photoacoustic transducer is immersed in homogeneous medium. The placement device may be integral to a medical or veterinary device. An aspect relates to a placement tracking system including the placement device and an ultrasound detector. An aspect relates to a method for tracking a portion of a placement device in a medium using the system.
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公开(公告)号：US20230200721A1
公开(公告)日：2023-06-29
申请号：US17927853
申请日：2021-05-31
Applicant: Agency for Science, Technology and Research , National University Hospital (Singapore) Pte Ltd
Inventor： Yao Du , Mahesh Choolani , Jun Hui Ho , Renzhe Bi , Poongkulali Rajarahm , Malini Olivo
CPC classification number: A61B5/4362 , A61B5/1072 , A61B5/0077 , A61B5/11
Abstract: A system for monitoring foetal growth. The system may include a plurality of devices. Each device of the plurality of devices may be configured to determine measurements of a baby bump over a time period, and may be further configured to store the measurements. The system may also include a server configured to receive the measurements from each of the plurality of devices. The server may be configured to compare the measurements from different devices of the plurality of devices. The system may be further configured to send an alert upon detecting an abnormality based on the measurements from the different devices of the plurality of devices.
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公开(公告)号：US20200367756A1
公开(公告)日：2020-11-26
申请号：US16960306
申请日：2019-01-14
Applicant: Agency for Science, Technology and Research
Inventor： Malini Olivo , Kapil Dev , Dinish Unnimadhava Kurup Soudamini Amma , Renzhe Bi
Abstract: Provided are a system and a method for in vivo detection of adipose tissue browning. The system includes a fiber probe configured to illuminate light on an adipose tissue site; a spectrometer configured to obtain diffuse reflectance spectrum information from the adipose tissue site; a chromophore measure determining module configured to determine a fraction of lipid chromophore with respect to lipid chromophore and water chromophore based on spectrally unmixing the diffuse reflectance spectrum information in a region of 1050 nm to 1400 nm; and a browning detector module configured to detect adipose tissue browning based on the fraction determined above.
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