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公开(公告)号:US20130108583A1
公开(公告)日:2013-05-02
申请号:US13475510
申请日:2012-05-18
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: C07D491/107 , A61K31/4355 , A61K45/06
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US08227509B2
公开(公告)日:2012-07-24
申请号:US13191545
申请日:2011-07-27
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: A61K315/35 , A61K31/27 , A61K31/54 , A61K31/56
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US20110230509A1
公开(公告)日:2011-09-22
申请号:US13090694
申请日:2011-04-20
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: A61K31/4355 , A61P35/00
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US20120077834A1
公开(公告)日:2012-03-29
申请号:US13191545
申请日:2011-07-27
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: A61K31/4355 , A61P35/02 , A61P35/00
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US20120015934A1
公开(公告)日:2012-01-19
申请号:US13102395
申请日:2011-05-06
IPC分类号: A61K31/55 , A61P35/02 , A61P35/00 , C07D491/20 , A61K31/4747
CPC分类号: C07D491/20 , C07D215/06
摘要: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
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公开(公告)号:US08895576B2
公开(公告)日:2014-11-25
申请号:US13475352
申请日:2012-05-18
IPC分类号: A61K31/44 , A61K31/56 , A61K31/4355 , A61K31/58 , A61K31/519 , A61K31/198 , A61K38/21 , A61K31/704 , A61K31/573 , A61K31/454 , A61K31/7068 , C07D491/04 , A61K31/7076 , C07D491/107 , C07D491/10 , A61K31/4745 , A61K31/17 , C07J69/00 , C07D491/048 , A61K45/06 , A61K31/69 , A61K31/664 , A61K31/196
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US20130108582A1
公开(公告)日:2013-05-02
申请号:US13475352
申请日:2012-05-18
申请人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
发明人: Alfredo C. Castro , Michael J. Grogan , William Matsui , Karen J. McGovern , Martin R. Tremblay
IPC分类号: C07D491/107 , A61K31/56 , A61K38/21 , A61K31/704 , A61K31/573 , A61K31/196 , A61K31/519 , A61K31/4745 , A61K31/69 , A61K31/198 , A61K31/17 , A61K31/664 , A61K31/454 , A61K31/7068 , A61K31/7076 , A61K31/4355
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供使用具有下式的环巴胺衍生物治疗各种病症的方法:
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公开(公告)号:US08293760B2
公开(公告)日:2012-10-23
申请号:US13102395
申请日:2011-05-06
IPC分类号: A61K31/4355 , C07D491/20
CPC分类号: C07D491/20 , C07D215/06
摘要: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
摘要翻译: 本发明涉及可用于治疗刺猬蛋白通路相关疾病,特别是癌症的类固醇生物碱。
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公开(公告)号:US20120065218A1
公开(公告)日:2012-03-15
申请号:US13168590
申请日:2011-06-24
IPC分类号: A61K31/4355 , A61P35/00 , A61P35/02 , C07D491/20
CPC分类号: C07D491/14 , C07D513/14
摘要: The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
摘要翻译: 本发明涉及可用于治疗刺猬蛋白通路相关疾病,特别是癌症的类固醇生物碱。
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公开(公告)号:US20080269272A1
公开(公告)日:2008-10-30
申请号:US12171208
申请日:2008-07-10
申请人: Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajan Nair Janardanan Nair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
发明人: Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajan Nair Janardanan Nair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
IPC分类号: A61K31/438 , C12N5/02 , A61P35/04
CPC分类号: C07D491/04
摘要: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
摘要翻译: 本发明提供用于调节平滑依赖性途径激活的组合物和方法。 本发明提供环巴胺的类似物,其可用于抵消刺猬蛋白途径的不期望的活化的表型效应,例如由刺猬蛋白获得功能,Ptc功能丧失或平滑获得功能突变引起的表型效应。 本发明的化合物特别可用于治疗癌症。
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