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公开(公告)号：US08669365B2
公开(公告)日：2014-03-11
申请号：US12199722
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , André B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , André B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D211/00 , C07D471/00 , C07D311/96
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US20120083484A1
公开(公告)日：2012-04-05
申请号：US13250080
申请日：2011-09-30
IPC分类号： A61K31/55 , A61P35/00 , A61P35/02 , C07D491/20
CPC分类号： C07D491/20 , C07D215/06
摘要： The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
摘要翻译： 本发明涉及可用于治疗刺猬蛋白通路相关疾病，特别是癌症的类固醇生物碱。
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公开(公告)号：US07812164B2
公开(公告)日：2010-10-12
申请号：US11965688
申请日：2007-12-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D401/00 , C07D515/02
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US09056877B2
公开(公告)日：2015-06-16
申请号：US13552473
申请日：2012-07-18
申请人： Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人： Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号： C07D277/20 , C07D513/04
CPC分类号： C07D513/04 , A61K31/519 , C07D519/00
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号：US08716479B2
公开(公告)日：2014-05-06
申请号：US12810600
申请日：2008-12-24
申请人： Brian C. Austad , Andre Lescarbeau , Lin-Chen Yu
发明人： Brian C. Austad , Andre Lescarbeau , Lin-Chen Yu
IPC分类号： C07D471/02 , C07D311/96
CPC分类号： C07J7/009 , C07B2200/09 , C07D471/10 , C07D491/22 , C07J1/0011 , C07J5/0053 , C07J9/00 , C07J21/00 , C07J43/006 , C07J63/00 , C07J65/00 , C07J69/00 , C07J71/0005
摘要： The invention is directed to a method to reduce a C—C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine.
摘要翻译： 本发明涉及一种降低甾族化合物的烯酮的C-C双键以产生“bgr”的混合物的方法。 酮产物和α-酮产物，包括在催化剂和取代的吡啶的存在下，用氢气处理溶剂中的甾族化合物的溶液或悬浮液。
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公开(公告)号：US20130029984A1
公开(公告)日：2013-01-31
申请号：US13552473
申请日：2012-07-18
申请人： Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人： Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号： A61K31/519 , A61K31/5377 , A61K31/4725 , A61P37/06 , C07D495/04 , A61P35/00 , A61P29/00 , C07D513/04 , A61K31/506
CPC分类号： C07D513/04 , A61K31/519 , C07D519/00
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号：US20120015934A1
公开(公告)日：2012-01-19
申请号：US13102395
申请日：2011-05-06
IPC分类号： A61K31/55 , A61P35/02 , A61P35/00 , C07D491/20 , A61K31/4747
CPC分类号： C07D491/20 , C07D215/06
摘要： The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
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公开(公告)号：US20090216022A1
公开(公告)日：2009-08-27
申请号：US12199722
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： C07D221/20 , C07D311/96
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
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公开(公告)号：US20090012109A1
公开(公告)日：2009-01-08
申请号：US12199689
申请日：2008-08-27
申请人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人： Brian Austad , Mark L. Behnke , Alfredo C. Castro , Andre B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号： A61K31/4355 , C07D221/20 , A61P35/00
CPC分类号： A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要： The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译： 本发明提供具有下式的环巴胺的新型衍生物：
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公开(公告)号：US08969363B2
公开(公告)日：2015-03-03
申请号：US13552460
申请日：2012-07-18
申请人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人： Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号： A61K31/519 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
摘要翻译： 本文描述了调节激酶活性（包括PI3激酶活性）的化合物和药物组合物，以及化合物，药物组合物和治疗与激酶活性（包括PI3激酶活性）相关的疾病和病症的方法。
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