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公开(公告)号:US20120015934A1
公开(公告)日:2012-01-19
申请号:US13102395
申请日:2011-05-06
IPC分类号: A61K31/55 , A61P35/02 , A61P35/00 , C07D491/20 , A61K31/4747
CPC分类号: C07D491/20 , C07D215/06
摘要: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
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公开(公告)号:US08293760B2
公开(公告)日:2012-10-23
申请号:US13102395
申请日:2011-05-06
IPC分类号: A61K31/4355 , C07D491/20
CPC分类号: C07D491/20 , C07D215/06
摘要: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
摘要翻译: 本发明涉及可用于治疗刺猬蛋白通路相关疾病,特别是癌症的类固醇生物碱。
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公开(公告)号:US08669365B2
公开(公告)日:2014-03-11
申请号:US12199722
申请日:2008-08-27
申请人: Brian Austad , Mark L. Behnke , Alfredo C. Castro , André B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人: Brian Austad , Mark L. Behnke , Alfredo C. Castro , André B. Charette , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号: C07D211/00 , C07D471/00 , C07D311/96
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供具有下式的环巴胺的新型衍生物:
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公开(公告)号:US07812164B2
公开(公告)日:2010-10-12
申请号:US11965688
申请日:2007-12-27
申请人: Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
发明人: Brian Austad , Mark L. Behnke , Alfredo C. Castro , Michael J. Grogan , Somarajannair Janardanannair , Andre Lescarbeau , Stephane Peluso , Martin Tremblay
IPC分类号: C07D401/00 , C07D515/02
CPC分类号: A61K31/4355 , A61K9/0014 , A61K31/17 , A61K31/196 , A61K31/198 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/664 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/21 , A61K45/06 , A61N5/10 , C07D307/94 , C07D471/04 , C07D471/10 , C07D491/04 , C07D491/048 , C07D491/10 , C07D491/107 , C07J69/00
摘要: The invention provides novel derivatives of cyclopamine having the following formula:
摘要翻译: 本发明提供具有下式的环巴胺的新型衍生物:
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公开(公告)号:US08969363B2
公开(公告)日:2015-03-03
申请号:US13552460
申请日:2012-07-18
申请人: Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人: Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号: A61K31/519 , C07D471/04 , C07D487/04
CPC分类号: C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
摘要翻译: 本文描述了调节激酶活性(包括PI3激酶活性)的化合物和药物组合物,以及化合物,药物组合物和治疗与激酶活性(包括PI3激酶活性)相关的疾病和病症的方法。
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公开(公告)号:US08785470B2
公开(公告)日:2014-07-22
申请号:US13552516
申请日:2012-07-18
申请人: Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人: Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号: C07D401/14 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D411/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , C12N9/1205 , C12Y207/01137 , Y02A50/414
摘要: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号:US09056877B2
公开(公告)日:2015-06-16
申请号:US13552473
申请日:2012-07-18
申请人: Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人: Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号: C07D277/20 , C07D513/04
CPC分类号: C07D513/04 , A61K31/519 , C07D519/00
摘要: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号:US20130029984A1
公开(公告)日:2013-01-31
申请号:US13552473
申请日:2012-07-18
申请人: Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人: Alfredo C. Castro , Catherine A. Evans , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号: A61K31/519 , A61K31/5377 , A61K31/4725 , A61P37/06 , C07D495/04 , A61P35/00 , A61P29/00 , C07D513/04 , A61K31/506
CPC分类号: C07D513/04 , A61K31/519 , C07D519/00
摘要: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号:US20130029982A1
公开(公告)日:2013-01-31
申请号:US13552460
申请日:2012-07-18
申请人: Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
发明人: Alfredo C. Castro , Catherine A. Evans , Somarajannair Janardanannair , Andre Lescarbeau , Tao Liu , Daniel A. Snyder , Martin R. Tremblay , Pingda Ren , Yi Liu , Liansheng Li , Katrina Chan
IPC分类号: A61K31/519 , C07D513/04 , C07D495/04 , A61K31/4375 , C07D487/04 , A61P37/00 , A61K31/53 , C07D473/34 , A61K31/52 , A61K31/5377 , A61P35/00 , A61P29/00 , C07D471/04 , A61K31/5025
CPC分类号: C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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公开(公告)号:US07964590B2
公开(公告)日:2011-06-21
申请号:US12044878
申请日:2008-03-07
IPC分类号: A61K31/55 , C07D491/20
CPC分类号: C07D491/20 , C07D215/06
摘要: The present invention relates to steroidal alkaloids useful in the treatment of hedgehog pathway related disorders, particularly cancer.
摘要翻译: 本发明涉及用于治疗刺猬蛋白通路相关疾病,特别是癌症的类固醇生物碱。
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