公开(公告)号：US20240327384A1

公开(公告)日：2024-10-03

申请号：US18580564

申请日：2022-07-21

Applicant: Amgen Inc.

Inventor： Tian WU ,  Prashant AGARWAL ,  Andreas R. ROTHELI ,  Hyunsoo PARK ,  Michael J. FROHN

IPC: C07D401/14 ,  A61K31/506 ,  C07C15/06 ,  C07C31/02 ,  C07C31/04 ,  C07C31/08 ,  C07C43/04 ,  C07C43/18 ,  C07C49/08 ,  C07C55/02 ,  C07C55/22 ,  C07C69/003 ,  C07C233/05 ,  C07C255/03 ,  C07C275/06 ,  C07C309/04 ,  C07C309/65 ,  C07C309/73 ,  C07D211/90 ,  C07D275/06 ,  C07D307/06 ,  C07D319/12 ,  C07D487/04

CPC classification number: C07D401/14 ,  A61K31/506 ,  C07C15/06 ,  C07C31/02 ,  C07C31/04 ,  C07C31/08 ,  C07C43/046 ,  C07C43/18 ,  C07C49/08 ,  C07C55/02 ,  C07C55/22 ,  C07C69/003 ,  C07C233/05 ,  C07C255/03 ,  C07C275/06 ,  C07C309/04 ,  C07C309/65 ,  C07C309/73 ,  C07D211/90 ,  C07D275/06 ,  C07D307/06 ,  C07D319/12 ,  C07D487/04 ,  C07B2200/13 ,  C07C2601/08

Abstract: Disclosed herein is a salt, a crystalline anhydrous form, a hydrate, a solvate, or a co-crystal of a free base compound 2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-[(2-hydroxyethanesulfonyl)amino]benzamide (Compound A); method of preparation, pharmaceutical compositions, and method of treating a disease mediated by a motor protein kinesin family member 18A (KIF18A) inhibition, wherein said disease is a neoplastic disease, including a cancer or a tumor.