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    Method for producing optically active naphthalene compound
    5.
    发明授权
    Method for producing optically active naphthalene compound 有权
    光学活性萘化合物的制造方法

    公开(公告)号：US09181217B2

    公开(公告)日：2015-11-10

    申请号：US14240466

    申请日：2012-08-24

    Applicant: Koji Matsuyama ,  Masanori Hatsuda ,  Masahiko Yoshinaga ,  Mitsuhiro Yada ,  Koichi Tanimoto

    Inventor： Koji Matsuyama ,  Masanori Hatsuda ,  Masahiko Yoshinaga ,  Mitsuhiro Yada ,  Koichi Tanimoto

    IPC: C07B53/00 ,  C07C25/06 ,  C07C255/03 ,  C07D401/04

    CPC classification number: C07D401/04 ,  C07B53/00 ,  C07C25/06 ,  C07C255/03

    Abstract: The present invention provides an industrially advantageous method for producing an optically active naphthalene compound useful as a therapeutic agent for dermatitis or the like. Specifically, the present invention provides a method for producing an optically active naphthalene compound [I], which comprises: a step of reacting a compound [a-1] and a compound [b-1] with each other in the presence of a base and a catalyst that is composed of a Pd compound and a tertiary phosphine ligand (step a); a step of asymmetrically hydrogenating a compound [c-1] in the presence of a hydrogen donor and a complex that is prepared from a ruthenium compound and a chiral ligand, or alternatively in the presence of an optically active oxazaborolidine compound (a CBS catalyst) and a boron hydride compound (step b); and a step of treating a compound [d-1] with a reducing agent (step c). (In the above formulae, Ra and Rb represent the same or different lower alkyl groups; and X1 represents a halogen atom.).

    Abstract translation: 本发明提供了用于制造用作皮炎等的治疗剂的光学活性萘化合物的工业上有利的方法。 具体而言，本发明提供了一种光学活性萘化合物[I]的制造方法，其特征在于，在碱的存在下，使化合物[a-1]和化合物[b-1] 和由Pd化合物和叔膦配体组成的催化剂（步骤a）; 在氢供体和由钌化合物和手性配体制备的络合物的存在下，或者在光学活性的恶唑硼烷化合物（CBS催化剂）存在下，不对称地氢化化合物[c-1] 和硼氢化合物（步骤b）; 和用还原剂处理化合物[d-1]（步骤c）的步骤。 （上述式中，Ra和Rb表示相同或不同的低级烷基，X1表示卤素原子。

    METHOD FOR CLEAVING UNSATURATED FATTY CHAINS
    7.
    发明申请
    METHOD FOR CLEAVING UNSATURATED FATTY CHAINS 有权
    消除不饱和脂肪链的方法

    公开(公告)号：US20140357880A1

    公开(公告)日：2014-12-04

    申请号：US14361391

    申请日：2012-11-22

    Applicant: Arkema France

    Inventor： Markus Brandhorst ,  Jean-Luc Dubois

    IPC: C07C51/285 ,  C07C253/22 ,  C07C253/30

    CPC classification number: C07C51/285 ,  C07C51/21 ,  C07C253/22 ,  C07C253/30 ,  C07C2523/30 ,  C07C255/07 ,  C07C255/19 ,  C07C255/03 ,  C07C255/17

    Abstract: The invention relates to a method for cleaving unsaturated fatty chains comprising a step of oxidative cleavage in which at least one fatty acid derivative having at least one unsaturation is reacted in the liquid phase with hydrogen peroxide in the presence of a catalyst for activating the reaction of oxidative cleavage and of molecular oxygen and in the absence of organic solvent.

    Abstract translation: 本发明涉及一种用于切割不饱和脂肪链的方法，其包括氧化裂解步骤，其中至少一种具有至少一个不饱和键的脂肪酸衍生物在液相中与过氧化氢在催化剂存在下反应， 氧化裂解和分子氧，并且在不存在有机溶剂的情况下。

    High-yield production of organic nitriles
    8.
    发明授权
    High-yield production of organic nitriles 有权
    高产量生产有机腈

    公开(公告)号：US08471052B2

    公开(公告)日：2013-06-25

    申请号：US12622782

    申请日：2009-11-20

    Applicant: Anil Oroskar ,  Paul Roman Kurek ,  Asha Oroskar

    Inventor： Anil Oroskar ,  Paul Roman Kurek ,  Asha Oroskar

    IPC: C07C253/00

    CPC classification number: C07C253/00 ,  C01C3/0204 ,  C07C253/34 ,  C07C255/03

    Abstract: A process is disclosed for producing organic nitriles such as Acetonitrile or Hydrogen Cyanide, in which yields may exceed 90%, undesirable by-products are not produced, and handling of ammonia gas is avoided. In one aspect, a process includes preparing a feed including ammonium salts and water; introducing the feed into a reactor containing a catalyst; and heating the feed in the presence of the catalyst. The catalyst may advantageously include molybdenum on a silica or silica alumina support. The feed may be ammonium acetate in water with about 50 wt % ammonium acetate and the balance water or ammonium formate in water. In another aspect, a process includes preparing a feed including ammonium hydroxide and acetic acid; introducing the feed into a reactor containing a catalyst; and heating the feed in the presence of the catalyst.

    Abstract translation: 公开了用于生产有机腈如乙腈或氰化氢的方法，其中产率可能超过90％，不会产生不期望的副产物，并且避免了氨气的处理。 一方面，一种方法包括制备包括铵盐和水的进料; 将进料引入含有催化剂的反应器中; 并在催化剂存在下加热进料。 催化剂可以有利地包括二氧化硅或二氧化硅氧化铝载体上的钼。 进料可以是水中的乙酸铵与约50重量％的乙酸铵和余量的水或甲酸铵的水溶液。 另一方面，一种方法包括制备包含氢氧化铵和乙酸的进料; 将进料引入含有催化剂的反应器中; 并在催化剂存在下加热进料。

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